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Publikováno v:
Journal of clinical pathology. 56(10)
Background: The immune system has been implicated in the pathogenesis of certain clinical manifestations of parvovirus B19 infection, including rash and arthralgia. Cytokines feature in the pathogenesis of parvovirus B19 infection, so inherited varia
Publikováno v:
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 28(4)
We have identified a new single nucleotide polymorphism within the promoter region of the human allograft inflammatory factor (AIF-1) gene. The polymorphism, defined by Genbank accession number AF097515, was characterized as a C/T single base pair su
Publikováno v:
Human immunology. 61(9)
We have described previously a variable length CA repeat sequence in the first intron of the human IFN-gamma gene and showed that allele #2 is associated with high in vitro IFN-gamma production. In a consecutive study, allele #2 was found to be assoc
Publikováno v:
Transplantation. 70(4)
In vitro production of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin 10 (IL-10), and transforming growth factor-beta (TGF-beta) correlate with their respective genetic polymorphisms. We analyzed the relationship b
Autor:
W J, Burlingham, P J, O'Connell, L M, Jacobson, B N, Becker, A D, Kirk, V, Pravica, I V, Hutchinson
Publikováno v:
Transplantation. 69(7)
Genomic DNA was obtained from peripheral blood samples of patients JB and DS each of whom received a kidney transplant at 16 years of age from a serologically HLA-DR matched and HLA-class I -mismatched donor. Both patients discontinued immunosuppress
Publikováno v:
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 27(1)
We have described two rare, single-nucleotide polymorphisms within the promoter regions of the IL-12 p35 and p40 subunit genes. Transitions C to T at position -916 from the transcription start of the IL-12 p35 gene and G to T at position -1287 in the
Autor:
A, Tagore, W M, Gonsalkorale, V, Pravica, A H, Hajeer, R, McMahon, P J, Whorwell, P J, Sinnott, I V, Hutchinson
Publikováno v:
Tissue antigens. 54(4)
Interleukin-10 (IL-10) is an anti-inflammatory cytokine. Its production in humans is under genetic control, and genotype defines high or low producers of this cytokine. This study addresses the hypothesis that idiopathic inflammatory bowel disease (I
Publikováno v:
Transplant immunology. 7(2)
Publikováno v:
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 26(1)
The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the associ