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Synthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazo-pyrazole-5-carboxamides. 2

Autor: P G, Baraldi, B, Cacciari, A, Leoni, M, Recanatini, M, Roberti, M, Rossi, S, Manfredini, V, Periotto, D, Simoni

Publikováno v: Farmaco (Societa chimica italiana : 1989). 46(11)

A series of 4-diazopyrazole-5-carboxamides 1 d-n has been synthesized and their antibacterial activity against a number of Gram-negative and Gram-positive strains has been tested. Some of the compounds resulted quite active and the whole set allowed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59d4307b1bf0fbace3b5d0696ac33818
https://pubmed.ncbi.nlm.nih.gov/1811619

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Synthesis and Interaction of 5-(Substituted-phenyl)-3-methy1-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8(7H)-ones with Benzodiazepine Receptors in Rat Cerebral Cortex

Autor: Mario Guarneri, Pier Giovanni Baraldi, V. Periotto, Daniele Simoni, Stefano Manfredini, Pier Andrea Borea

Publikováno v: Journal of Medicinal Chemistry. 28:683-685

On the basis of the anxiolytic property of ripazepam, 1-ethyl-4,6-dihydro-3- methyl-8-phenylpyrazolo[4,3-e][1,4]diazepin-5(1H)-one (1), a series of isomeric 5-(phenyl-substituted)pyrazolo[4,3-e][1,4] diazepin-8-ones 3a-f were prepared and tested for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e631b71981ba7f7f5cc90039a9ef5fb1
https://doi.org/10.1021/jm50001a025

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Synthesis of 1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones and pyrazolo-5-carboxamides and interaction with benzodiazepine and adenosine A1 receptors in rat cerebral cortex

Autor: P G, Baraldi, A, Casolari, S, Manfredini, V, Periotto, V, Zanirato, C, Florio, V, Traversa, G M, Bertelli, P A, Borea

Publikováno v: Arzneimittel-Forschung. 38(9)

The effects of several newly synthesized pyrazolo [4,3-d] pyrimidine-7-ones and pyrazolo-5-carboxamides on [3H]-flunitrazepam and [3H]-cyclohexyladenosine binding in rat cerebral cortex membranes have been studied. The compounds under examination, di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f830661d19907ec0c7575963f72d26fe
https://pubmed.ncbi.nlm.nih.gov/2852012

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Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in rat cerebral cortex

Autor: P G, Baraldi, S, Manfredini, V, Periotto, D, Simoni, M, Guarneri, P A, Borea

Publikováno v: Journal of medicinal chemistry. 28(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5be4ae51a4c585878c8f3831fc16a6a5
https://pubmed.ncbi.nlm.nih.gov/2985787

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Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-beta-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyr imi din-7-ones

Autor: R. Manservigi, E. Cassai, V. Periotto, Valerio Bertolasi, Stefano Manfredini, Mario Guarneri, Daniele Simoni, P. G. Baraldi

Publikováno v: Journal of medicinal chemistry. 27(8)

N1 analogues of formycin B, with substituents at the 3 and 6 positions of the pyrazolo[4,3-d]pyrimidine moiety were synthesized by the direct SnCl4-catalyzed ribosylation method. The site of the glycosidic linkage and the anomeric configurations were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352616864feab6e5f684c3995e1b0113
https://pubmed.ncbi.nlm.nih.gov/6086926

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Studies on trypsin inhibitors. Part VIII. Synthesis of the protected octatriacontapeptide corresponding to the sequence 15-52 of porcine pancreatic secretory trypsin inhibitor II (Kazal)

Autor: R, Tomatis, A, Guggi, S, Salvadori, V, Periotto, R, Rocchi

Publikováno v: International journal of peptide and protein research. 11(4)

The synthesis by fragment condensation of protected peptides corresponding to the amino acid sequences 15-35, 25-52 and 15-52 of porcine pancreatic secretory trypsin inhibitor II (Kazal type) is described. The Rudinger modification of the azide proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::848073860e1ff1db93a013c872426f51
https://pubmed.ncbi.nlm.nih.gov/566731

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ChemInform Abstract: SYNTHESIS AND INTERACTION OF 5-(SUBSTITUTED-PHENYL)-3-METHYL-6,7-DIHYDROPYRAZOLO(4,3-E)(1,4)DIAZEPIN-8(7H)-ONES WITH BENZODIAZEPINE RECEPTORS IN RAT CEREBRAL CORTEX

Autor: Daniele Simoni, Mario Guarneri, Pier Giovanni Baraldi, Pier Andrea Borea, V. Periotto, Stefano Manfredini

Publikováno v: Chemischer Informationsdienst. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4834ad97e21f62e71437825410332825
https://doi.org/10.1002/chin.198534251

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