Zobrazeno 1 - 10
of 757
pro vyhledávání: '"V, Nussenzweig"'
Autor:
Photini Sinnis, V Nussenzweig, Weidong Li, Satoshi Omura, Joon Mo Myung, Marcelo R.S. Briones, Soren Gantt, E. J. Corey
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:2731-2738
Proteasomes degrade most of the proteins inside eukaryotic cells, including transcription factors and regulators of cell cycle progression. Here we show that nanomolar concentrations of lactacystin, a specific irreversible inhibitor of the 20S protea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b13e020432550d594978541ef478a4
https://doi.org/10.1128/aac.42.10.2731
https://doi.org/10.1128/aac.42.10.2731
Autor:
S Tomlinson, V Nussenzweig
Publikováno v:
The Journal of Immunology. 159:5606-5609
Human serum is effective at lysing unsensitized rabbit erythrocytes due to activation of the alternative complement pathway. Hemolysis is known to be enhanced by the addition of human IgG. We demonstrate that the enhancement of alternative pathway-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d890b0485ebe458db2d2f5acf269736
https://doi.org/10.4049/jimmunol.159.11.5606
https://doi.org/10.4049/jimmunol.159.11.5606
Publikováno v:
The Journal of Experimental Medicine
The initial phase of membrane attack by complement is the interaction between C5b6, C7, and the cell membrane that leads to the insertion of C5b-7. Here we investigate the role of sialic acid residues in the assembly of C5b-7 intermediates on erythro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b814843b0d629d4237f463b794dc9f
https://doi.org/10.1084/jem.184.4.1225
https://doi.org/10.1084/jem.184.4.1225
Publikováno v:
The Journal of Immunology. 152:1927-1934
The membrane glycoprotein CD59 protects host cells from homologous complement attack by inhibiting the assembly of the membrane attack complex. CD59 binds to C8 and C9 in the nascent membrane attack complex and interferes with C9 membrane insertion a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac9d4f71647442983c5e3bab7459afa1
https://doi.org/10.4049/jimmunol.152.4.1927
https://doi.org/10.4049/jimmunol.152.4.1927
Autor:
L C Pontes de Carvalho, A B Clarkson, M S Jiang, Gerald W. Hart, Stephen Tomlinson, E J Bienen, F Vandekerckhove, V Nussenzweig
Publikováno v:
The Journal of Experimental Medicine
Here we report the presence of a trans-sialidase on the surface of Trypanosoma brucei culture-derived procyclic trypomastigotes. The enzyme is not detected in lysates of bloodstream trypomastigotes enriched for either stumpy or slender forms. The tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4665d7830566885e9cbda2c1ee46bd8f
https://doi.org/10.1084/jem.177.2.465
https://doi.org/10.1084/jem.177.2.465
Publikováno v:
Blood. 81:510-516
Erythrocytes shed membrane vesicles in response to many stimuli. It has been previously demonstrated that glycan phosphatidylinositol-linked (GPI-linked) proteins such as decay accelerating factor and acetylcholinesterase are concentrated in these ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6126332c01d023de1232d4a8199004bd
https://doi.org/10.1182/blood.v81.2.510.bloodjournal812510
https://doi.org/10.1182/blood.v81.2.510.bloodjournal812510
Publikováno v:
The Journal of Immunology. 147:2638-2642
Nucleated cells can resist attack by C by exocytosis or endocytosis of the terminal C components C5b-9 (membrane attack complex) (MAC), but it is generally accepted that formation of a single MAC channel on E leads to lysis (one-hit theory). We find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d1c9c51bdb500471d79012a15912f5
https://doi.org/10.4049/jimmunol.147.8.2638
https://doi.org/10.4049/jimmunol.147.8.2638
Publikováno v:
The Journal of Experimental Medicine
The protozoan parasite Trypanosoma cruzi can infect many distinct mammalian cell types. The parasites enter cells through the formation of phagocytic vacuoles, but later are found free in the cytosol, where they multiply as amastigotes. Using transmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf2120462790f2327e8d8426e2b2614
https://doi.org/10.1084/jem.171.2.401
https://doi.org/10.1084/jem.171.2.401
Publikováno v:
The Journal of Experimental Medicine
Scopus-Elsevier
Scopus-Elsevier
We show here an effective and novel approach to engineer peptide-based vaccines using a chemically defined system, known as multiple peptide antigen systems (MAPs), to protect an inbred mouse strain from infection against rodent malaria. 10 mono- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2724c72ca4d3896fd8929c4e2e496536
https://doi.org/10.1084/jem.171.1.299
https://doi.org/10.1084/jem.171.1.299
Autor:
S. Nussenzweig, V. Nussenzweig
Publikováno v:
Annales de Parasitologie Humaine et Comparée. 65:49-52
A sporozoite malaria vaccine which elicits high levels of antibodies to the circumsporozoite (CS) protein may protect part of the human population in areas of low endemicity. Other possible targets of a sporozoite vaccine are the liver stages, but in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618d5202200a1904257767f4e8cb0338
https://doi.org/10.1051/parasite/1990651049
https://doi.org/10.1051/parasite/1990651049