Zobrazeno 1 - 10
of 381
pro vyhledávání: '"V, Levine"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Molecular dynamics simulations reveal the allosteric mechanism leading to an open, lipid scrambling competent state of a mammalian TMEM16F.
Externí odkaz:
https://doaj.org/article/578de32c6a854da4adc4db631a4528a6
Autor:
Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conforma
Externí odkaz:
https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1
Autor:
Edlyn V. Levine
Publikováno v:
Queue. 21:66-87
Evidence abounds that the human brain does not innately think scientifically; however, it can be taught to do so. The same species that forms cargo cults around widespread and unfounded beliefs in UFOs, ESP, and anything read on social media also pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdf62740702842476de606f9c89273c
https://doi.org/10.1145/3595860
https://doi.org/10.1145/3595860
Autor:
Daniel S. Terry, Rachel A. Kolster, Matthias Quick, Michael V. LeVine, George Khelashvili, Zhou Zhou, Harel Weinstein, Jonathan A. Javitch, Scott C. Blanchard
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Neurotransmitter:sodium symporters (NSS) modulate the duration and magnitude of signaling via the sodium-coupled reuptake of neurotransmitters. Here the authors describe quantitative single molecule imaging of ligand-induced, functional dynamics of b
Externí odkaz:
https://doaj.org/article/97de270984c541fa90101d0a86508a1f
Publikováno v:
The Journal of Physical Chemistry B. 126:4442-4457
Although molecular dynamics (MD) simulations have been used extensively to study the structural dynamics of proteins, the role of MD simulation in studies of nucleic acid based systems has been more limited. One contributing factor to this disparity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01804d8676abbbd2eaf6f8a0a7b11afd
https://doi.org/10.1021/acs.jpcb.1c10971
https://doi.org/10.1021/acs.jpcb.1c10971
Publikováno v:
IEEE Solid-State Circuits Letters. 5:247-250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6885f7168554b8c8c837960c0a03cf24
https://doi.org/10.1109/lssc.2022.3211705
https://doi.org/10.1109/lssc.2022.3211705
Autor:
Michael V. LeVine, Harel Weinstein
Publikováno v:
Entropy, Vol 17, Iss 5, Pp 2895-2918 (2015)
In performing their biological functions, molecular machines must process and transmit information with high fidelity. Information transmission requires dynamic coupling between the conformations of discrete structural components within the protein p
Externí odkaz:
https://doaj.org/article/c3a64b34c2644c3089227a5b941b8c9f
Publikováno v:
Journal of Geophysical Research: Space Physics. 127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71af5e0c4ee013ab28fc405362cb3497
https://doi.org/10.1029/2022ja030699
https://doi.org/10.1029/2022ja030699
Publikováno v:
International Symposium for Testing and Failure Analysis.
One approach for finding faults in integrated circuits (ICs) is magnetic imaging, where we map the magnetic fields emitted by internal currents in the device and use this knowledge to infer the current paths and fault locations. This gives us access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f09025d2da9494c1952532dd25577a87
https://doi.org/10.31399/asm.cp.istfa2022p0007
https://doi.org/10.31399/asm.cp.istfa2022p0007
Autor:
Lindsay D Clark, Igor Dikiy, Karen Chapman, Karin EJ Rödström, James Aramini, Michael V LeVine, George Khelashvili, Søren GF Rasmussen, Kevin H Gardner, Daniel M Rosenbaum
Publikováno v:
eLife, Vol 6 (2017)
GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands. Yet there is no experimental evidence for how sidechain dynamics control allosteric transi
Externí odkaz:
https://doaj.org/article/0e6a3d7fea4c4ae28c73643d606afa6b