Výsledky vyhledávání

Akademický článek

The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor

Autor: Emmanuelle V. LeBlanc, Che C. Colpitts

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emphasized the serious threat to human health posed by emerging coronaviruses. Effective broadly-acting antiviral countermeasures are urgent

Externí odkaz: https://doaj.org/article/fd157addde694247927e202b217bc2bd

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals

Autor: Evelyn Jagoda, Davide Marnetto, Gayani Senevirathne, Victoria Gonzalez, Kaushal Baid, Francesco Montinaro, Daniel Richard, Darryl Falzarano, Emmanuelle V LeBlanc, Che C Colpitts, Arinjay Banerjee, Luca Pagani, Terence D Capellini

Publikováno v: eLife, Vol 12 (2023)

Individuals infected with the SARS-CoV-2 virus present with a wide variety of symptoms ranging from asymptomatic to severe and even lethal outcomes. Past research has revealed a genetic haplotype on chromosome 3 that entered the human population via

Externí odkaz: https://doaj.org/article/39bebb50ae4f4e91aaf3db376ba9bbd1

Zobrazit plný text záznamu

Akademický článek

Activation of TLR4 by viral glycoproteins: A double-edged sword?

Autor: Emily A. Halajian, Emmanuelle V. LeBlanc, Katrina Gee, Che C. Colpitts

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Recognition of viral infection by pattern recognition receptors is paramount for a successful immune response to viral infection. However, an unbalanced proinflammatory response can be detrimental to the host. Recently, multiple studies have identifi

Externí odkaz: https://doaj.org/article/eb6be532a9374ae088502c4ec35e2c4e

Zobrazit plný text záznamu

Akademický článek

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstr

Externí odkaz: https://doaj.org/article/c204109fbee74209af84981ef754b8a6

Zobrazit plný text záznamu

Akademický článek

Reducing hypnotic use in insomnia management among Australian veterans: results from repeated national interventions

Autor: Lisa M. Kalisch Ellett, Renly Lim, Nicole L. Pratt, Mhairi Kerr, Emmae N. Ramsay, Tammy V. LeBlanc, John D. Barratt, Elizabeth E. Roughead

Publikováno v: BMC Health Services Research, Vol 18, Iss 1, Pp 1-10 (2018)

Abstract Background The Australian Government Department of Veterans’ Affairs (DVA) Veterans’ Medicines Advice and Therapeutics Education Services (Veterans’ MATES) programme conducted two intervention (March 2009, follow-up intervention June 2

Externí odkaz: https://doaj.org/article/56d116daa7894abc8b95f3877dd683d5

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies

Autor: Emmanuelle V. LeBlanc, Youjin Kim, Chantelle J. Capicciotti, Che C. Colpitts

Publikováno v: Pathogens, Vol 10, Iss 6, p 685 (2021)

Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow e

Externí odkaz: https://doaj.org/article/a20a565a53a049feba5f1e0f660c4e9f

Zobrazit plný text záznamu