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of 135
pro vyhledávání: '"V, Günzler"'
Autor:
S. Leiler, J. M. Kalisnik, R. Bernik, A. Bauer, V. Günzler, P. Sluet, S. Kounev, T. Fischlein
Publikováno v:
The Thoracic and Cardiovascular Surgeon.
Akademický článek
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Publikováno v:
Biochemical Journal. 300:525-530
The potency of oxalyl amino acid derivatives as inhibitors of prolyl 4-hydroxylase was studied in vitro, in isolated microsomes and in chicken embryonic-tissue culture. These compounds represent structural analogues of 2-oxoglutarate in which the -CH
Publikováno v:
Biochemical Journal. 286:923-927
A search for conserved amino acid residues within the cDNA-derived amino acid sequences of 2-oxoglutarate-coupled dioxygenases revealed the presence of two distinct motifs, spaced 49-71 amino acids apart, toward the C-terminal regions of these protei
Publikováno v:
Biochemical Journal. 275:469-476
The biochemical and morphological consequences of procollagen prolyl 4-hydroxylase inhibition by pyridine-2,4-dicarboxylic acid (2,4-PDCA) and its diethyl ester (diethyl-2,4-PDC) were studied in chick-embryo calvaria, which predominantly synthesize t
Publikováno v:
Journal of Hepatology. 13:S35-S40
The model of biliary cirrhosis by bile duct ligation was further characterized using PIIIP, 7S-collagen as well as standard enzymes in the serum, prolyl 4-hydroxylase and total hydroxyproline in the liver and light microscopical histology. Five weeks
Publikováno v:
Journal of Hepatology. 13:S26-S34
S 0885 and HOE 077 inhibit CCl 4 -induced liver fibrosis in rats, as shown by significantly reduced hydroxyproline content of the liver and improved liver histology. Mortality of drug-treated animals is significantly diminished. Serum collagen parame
Autor:
K Karvonen, Kari I. Kivirikko, Taina Pihlajaniemi, Tarja Helaakoski, Leena Ala-Kokko, V Günzler, S Henke, Eeva-Riitta Savolainen
Publikováno v:
Scopus-Elsevier
The crucial role of collagen in fibrotic disorders has prompted attempts to develop drugs that inhibit collagen accumulation. Peptides containing the unphysiological amino acid 5-oxaproline (Opr) have recently been found to act as specific syncatalyt
Autor:
M, Bickel, K H, Baringhaus, M, Gerl, V, Günzler, J, Kanta, L, Schmidts, M, Stapf, G, Tschank, K, Weidmann, U, Werner
Publikováno v:
Hepatology (Baltimore, Md.). 28(2)
Fibrosis and cirrhosis of the liver are often the result of chronic liver damage by a variety of different agents. Pathological accumulation of collagen, disruption of the lobular structure, and impaired hepatocellular function frequently lead to sys
Publikováno v:
Hepato-gastroenterology. 44(16)
Laminin P1 serum levels run parallel to the accumulation of hepatic extracellular matrix in patients with liver cirrhosis. Recent studies reported a correlation between laminin P1 and portal pressure, leading to the proposal that laminin P1 may be us