Zobrazeno 1 - 10
of 237
pro vyhledávání: '"V, Chew"'
Autor:
Peter S. Lee, Katherine G. MacDonald, Evan Massi, Pamela V. Chew, Christine Bee, Padma Perkins, Bryant Chau, Kent Thudium, Jack Lohre, Pradyot Nandi, Ekaterina G. Deyanova, Ishita Barman, Olafur Gudmundsson, Gavin Dollinger, Tim Sproul, John J. Engelhardt, Pavel Strop, Arvind Rajpal
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment. We hypothesized that an acidic pH-selective ipilimumab (pH Ipi), whi
Externí odkaz:
https://doaj.org/article/691eb159503a4399a519acfc7748ae85
Autor:
Amanda J Lee, Emily Feng, Marianne V Chew, Elizabeth Balint, Sophie M Poznanski, Elizabeth Giles, Ali Zhang, Art Marzok, Spencer D Revill, Fatemeh Vahedi, Anisha Dubey, Ehab Ayaub, Rodrigo Jimenez-Saiz, Joshua J C McGrath, Tyrah M Ritchie, Manel Jordana, Danny D Jonigk, Maximilian Ackermann, Kjetil Ask, Matthew Miller, Carl D Richards, Ali A Ashkar
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010471 (2022)
The ability to treat severe viral infections is limited by our understanding of the mechanisms behind virus-induced immunopathology. While the role of type I interferons (IFNs) in early control of viral replication is clear, less is known about how I
Externí odkaz:
https://doaj.org/article/bac7c41243064cfda47eb006b0f0cc7c
Autor:
Ana L. Portillo, Richard Hogg, Sophie M. Poznanski, Eduardo A. Rojas, Niamh J. Cashell, Joanne A. Hammill, Marianne V. Chew, Mira M. Shenouda, Tyrah M. Ritchie, Quynh T. Cao, Jeremy A. Hirota, Sukhbinder Dhesy-Thind, Jonathan L. Bramson, Ali A. Ashkar
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102619- (2021)
Summary: Despite the remarkable success of chimeric antigen receptor (CAR)-T cells against hematologic malignancies, severe off-tumor effects have constrained their use against solid tumors. Recently, CAR-engineered natural killer (NK) cells have eme
Externí odkaz:
https://doaj.org/article/be2ea8985203437bad60b92b16b38d23
Autor:
Sophie M Poznanski, Tyrah M Ritchie, Isabella Y Fan, Abdullah El-Sayes, Ana L Portillo, Ronny Ben-Avi, Eduardo A Rojas, Marianne V Chew, Yaron Shargall, Ali A Ashkar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Lung cancer remains the leading cause of cancer death worldwide despite the significant progress made by immune checkpoint inhibitors, including programmed death receptor-1 (PD1)/PD ligand 1 (PDL1)-blockade therapy. PD1/PDL1−blockade has achieved u
Externí odkaz:
https://doaj.org/article/5c2b468f76e44401addc26aa4764c247
IFN- signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity
Autor:
Yalda Karimi, Elizabeth C Giles, Fatemeh Vahedi, Marianne V Chew, Tina Nham, Dessi Loukov, Amanda J Lee, Dawn ME Bowdish, Ali A Ashkar
Publikováno v:
Innate Immunity, Vol 26 (2020)
Type I IFN holds a critical role in host defence, providing protection against pathogenic organisms through coordinating a pro-inflammatory response. Type I IFN provides additional protection through mitigating this inflammatory response, preventing
Externí odkaz:
https://doaj.org/article/010956b6f2b54f88b1769ebf27c59106
Autor:
Mira M. Shenouda, Amy Gillgrass, Tina Nham, Richard Hogg, Amanda J. Lee, Marianne V. Chew, Mahsa Shafaei, Craig Aarts, Dean A. Lee, John Hassell, Anita Bane, Sukhbinder Dhesy-Thind, Ali A. Ashkar
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-14 (2017)
Abstract Background Natural killer (NK) cells play a critical role in cancer immunosurveillance. Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of activated NK cells from a small volume of peripheral blood. We
Externí odkaz:
https://doaj.org/article/e54463b04cb049b2a8ca924521f7ce2a
Publikováno v:
Journal of the Medical Library Association, Vol 107, Iss 4 (2019)
Background: As the need to demonstrate research impact increases, faculty are looking for new ways to show funders, departments, and institutions that their work is making a difference. While traditional metrics such as citation counts can tell one p
Externí odkaz:
https://doaj.org/article/6c4c3abe871e429cb6f815668244d457
Autor:
Amanda J. Lee, Firoz Mian, Sophie M. Poznanski, Michele Stackaruk, Tiffany Chan, Marianne V. Chew, Ali A. Ashkar
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
NK cells are a key antiviral component of the innate immune response to HSV-2, particularly through their production of IFN-γ. It is still commonly thought that type I IFN activates NK cell function; however, rather than requiring the type I IFN rec
Externí odkaz:
https://doaj.org/article/afa462e16097466aaae09852f512e2ee
Akademický článek
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Autor:
Ali A. Ashkar, Hal W. Hirte, Dean A. Lee, Jonathan L. Bramson, Martin Butcher, Isabella Y. Fan, Joanne A. Hammill, Amanda J. Lee, Marianne V. Chew, Tina Nham, Sophie M. Poznanski
Natural killer (NK) cells are useful for cancer immunotherapy and have proven clinically effective against hematologic malignancies. However, immunotherapies for poor prognosis solid malignancies, including ovarian cancer, have not been as successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28fde7221724f3dcb346f3da713a0077
https://doi.org/10.1158/2326-6066.c.6548206.v1
https://doi.org/10.1158/2326-6066.c.6548206.v1
