Elucidating the genotoxicity of Fusobacterium nucleatum-secreted mutagens in colorectal cancer carcinogenesis

Autor: Wenye Xu, Yuchen Zhang, Dongjiao Chen, Dan Huang, Yang Zhao, Wei Hu, Ling Lin, Yingzhi Liu, Shilan Wang, Judeng Zeng, Chuan Xie, Hung Chan, Qing Li, Huarong Chen, Xiaodong Liu, Sunny H. Wong, Jun Yu, Francis K. L. Chan, Matthew T. V. Chan, Siew C. Ng, William K. K. Wu, Lin Zhang

Publikováno v: Gut Pathogens, Vol 16, Iss 1, Pp 1-13 (2024)

Abstract Background Fusobacterium nucleatum (F. nucleatum) is one of the key tumorigenic bacteria in colorectal cancer (CRC), yet how F. nucleatum is involved in colorectal cancer carcinogenesis remains unknown. Results In the present study, we carri

Externí odkaz: https://doaj.org/article/b61bd6e59fff42d584fb0a93eec26fe1

Trends among platelet function, arterial calcium, and vascular function measures

Autor: Jason Cunha, Melissa V. Chan, Bongani B. Nkambule, Florian Thibord, Amber Lachapelle, Robin E. Pashek, Ramachandran S. Vasan, Jian Rong, Emelia J. Benjamin, Naomi M. Hamburg, Ming-Huei Chen, Gary F. Mitchell, Andrew D. Johnson

Publikováno v: Platelets, Vol 34, Iss 1 (2023)

Arterial tonometry and vascular calcification measures are useful in cardiovascular disease (CVD) risk assessment. Prior studies found associations between tonometry measures, arterial calcium, and CVD risk. Activated platelets release angiopoietin-1

Externí odkaz: https://doaj.org/article/2cc9f209cc8249bc8794e3a9e2ed04d1

Lower gut abundance of Eubacterium rectale is linked to COVID-19 mortality

Autor: Yingzhi Liu, Matthew T. V. Chan, Francis K. L. Chan, William K. K. Wu, Siew C. Ng, Lin Zhang

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

IntroductionEmerging preclinical and clinical studies suggest that altered gut microbiome composition and functions are associated with coronavirus 2019 (COVID- 19) severity and its long-term complications. We hypothesize that COVID-19 outcome is ass

Externí odkaz: https://doaj.org/article/38fd4c22b4c940dcb2027f6b0199e443

DIII-D research to provide solutions for ITER and fusion energy

Autor: C.T. Holcomb, for the DIII-D Team:, J. Abbate, A. Abe, A. Abrams, P. Adebayo-Ige, S. Agabian, S. Ahmed, N. Aiba, N. Akcay, T. Akiyama, R. Albosta, P. Aleynikov, S. Allen, H. Anand, J. Anderson, Y. Andrew, M. Ashburn, A. Ashourvan, M. Austin, G. Avdeeva, D. Ayala, M. Ayub, E. Bagdy, S. Banerjee, K. Barada, L. Bardoczi, O. Bardsley, J. Barr, E. Bass, A. Battey, Z. Bayler, L. Baylor, T. Bechtel, M. Beidler, E. Belli, T. Benedett, Z. Bergstrom, M. Berkel, T. Bernard, N. Bertelli, R. Bielajew, G. Bodner, J. Boedo, R. Boivin, T. Bolzonella, P. Bonoli, A. Bortolon, S. Bose, M. Boyer, W. Boyes, L. Bradley, R. Brambila, A. Braun, D. Brennan, S. Bringuier, L. Brodsky, M. Brookman, J. Brooks, D. Brower, W. Brown, J. Buck, S. Buczek, D. Burgess, M. Burke, K. Burrell, J. Butt, R. Buttery, I. Bykov, P. Byrne, A. Cacheris, K. Callahan, J. Callen, D. Campbell, J. Candy, J. Canik, L. Cappelli, T. Carlstrom, R. Carr, W. Carrig, B. Carter, T. Carter, I. Carvalho, W. Cary, L. Casali, L. Ceelen, M. Cengher, M. Cha, R. Chaban, V. Chan, B. Chapman, I. Char, J. Chen, R. Chen, X. Chen, Y. Chen, J. Chiriboga, E. Cho, G. Choi, W. Choi, H. Choudhury, S. Chowdhury, C. Chrystal, Y. Chung, R. Churchill, R. Clark, M. Clement, J. Coburn, S. Coda, R. Coffee, C. Collins, J. Colmenares-Fernandez, W. Conlin, R. Coon, T. Cote, A. Creely, N. Crocker, C. Crowe, B. Crowley, T. Crowley, M. Curie, D. Curreli, A. Dal Molin, J. Damba, E. Dart, A. Dautt-Silva, K. Davda, A. De, N. de Boucaud, Y. de Jong, P. DE VRIES, A. de-Villeroche, G. DeGrandchamp, J. deGrassie, D. Demers, S. Denk, E. DeShazer, S. Di Genova, A. Diallo, A. Dimits, R. Ding, S. Ding, D. Donovan, X. Du, J. Dunsmore, A. Dupuy, J. Duran, A. Dvorak, F. Effenberg, N. Eidietis, D. Elder, D. Eldon, Y. Elsey, D. Ennis, K. Erickson, D. Ernst, M. Fajardo, H. Farre-Kaga, M. Fenstermacher, N. Ferraro, J. Ferron, A. Feyrer, P. Fimognari, R. Finden, D. Finkenthal, R. Fitzpatrick, S. Flanagan, B. Ford, W. Fox, S. Freiberger, L. Fu, K. Gage, V. Gajaraj, I. Garcia, F. Garcia, A. Garcia, M. Garcia Munoz, D. Garnier, A. Garofalo, A. Gattuso, B. Geiger, K. Gentle, Y. Ghai, K. Gill, F. Glass, P. Gohil, X. Gong, J. Gonzalez-Martin, Y. Gorelov, V. Graber, R. Granetz, C. Gray, C. Greenfield, B. Grierson, R. Groebner, W. Grosnickle, M. Groth, S. Gu, H. Guo, J. Guterl, W. Guttenfelder, R. Hager, S. Hahn, M. Halfmoon, J. Hall, V. Hall-Chen, F. Halpern, G. Hammett, X. Han, C. Hansen, E. Hansen, J. Hanson, M. Hanson, A. Harris, R. Harvey, S. Haskey, D. Hatch, W. Hayashi, A. Hayes, W. Heidbrink, J. Herfindal, J. Hicok, E. Hinson, T. Hisakado, C. Holcomb, C. Holland, L. Holland, E. Hollmann, A. Holm, I. Holmes, K. Holtrop, R. Hong, R. Hood, L. Horvath, S. Houshmandyar, N. Howard, E. Howell, W. Hu, Y. Hu, Q. Hu, Y. Huang, J. Huang, A. Huang, A. Hubbard, J. Hughes, D. Humphreys, J. Hurtado, A. Hyatt, K. Imada, V. Izzo, A. Jalalvand, S. Jardin, A. Jarvinen, Y. Jeon, H. Ji, X. Jian, L. Jian, Y. Jiang, C. Johnson, J. Johnson, M. Jones, S. Joung, P. Jouzdani, E. Jung, E. Kallenberg, R. Kalling, D. Kaplan, A. Kaptanoglu, D. Kellman, J. Kennedy, F. Khabanov, J. Kim, H. Kim, E. Kim, S. Kim, K. Kim, C. Kim, T. Kim, J. King, A. Kinsey, D. Kirk, D. Klasing, A. Kleiner, M. Knolker, M. Kochan, B. Koel, J. Koenders, M. Koepke, R. Kolasinski, E. Kolemen, E. Kostadinova, M. Kostuk, G. Kramer, R. Kube, N. Kumar, R. La Haye, F. Laggner, C. Lahban, H. Lan, R. Landry, R. Lantsov, L. Lao, C. Lasnier, C. Lau, R. Leccacorvi, J. Leddy, M. Lee, S. Lee, K. Lee, R. Lee, M. Lehnen, A. Leonard, E. Leppink, M. LeSher, J. Lestz, J. Leuer, N. Leuthold, G. Li, X. Li, Y. Li, L. Li, N. Li, Z. Li, D. Lin, Z. Lin, Y. Lin, E. Linsenmayer, J. Liu, D. Liu, C. Liu, Z. Liu, Y. Liu, A. Loarte-Prieto, S. Loch, L. LoDestro, N. Logan, J. Lohr, J. Lore, U. Losada Rodriguez, J. Loughran, M. Lowell, T. Luce, N. Luhmann, P. Lunia, R. Lunsford, L. Lupin-Jimenez, A. Lvovskiy, B. Lyons, X. Ma, J. MacDonald, T. Macwan, R. Maingi, M. Major, L. Malhotra, M. Margo, C. Marini, A. Marinoni, A. Maris, E. Martin, J. Mateja, R. Mattes, R. Maurizio, D. Mauzey, L. McAllister, G. McArdle, J. McClenaghan, K. McCollam, G. McKee, K. McLaughlin, A. McLean, V. Mehta, E. Meier, S. Meitner, J. Menard, O. Meneghini, G. Merlo, S. Messer, W. Meyer, C. Michael, D. Miller, M. Miller, J. Mitchell, E. Mitra, C. Moeller, M. Mohamed, S. Molesworth, K. Montes, S. Mordijck, S. Morosohk, A. Moser, D. Mueller, S. Munaretto, C. Murphy, C. Muscatello, R. Myers, A. Nagy, D. Nath, M. Navarro, R. Nazikian, T. Neiser, A. Nelson, P. Nesbet, F. Nespoli, P. Nguyen, D. Nguyen, R. Nguyen, J. Nichols, M. Nocente, L. Nuckols, R. Nygren, T. Odstrcil, M. Okabayashi, E. Olofsson, D. Orlov, D. Orozco, N. Osborne, T. Osborne, F. OShea, D. Pace, D. Packard, A. Pajares Martinez, C. Pakosta, C. Pan, M. Pandya, D. Panici, A. Pankin, Y. Park, J. Park, C. Parker, S. Parker, P. Parks, M. Parsons, S. Paruchuri, C. Paz-Soldan, T. Pederson, W. Peebles, B. Penaflor, E. Perez, L. Periasamy, R. Perillo, C. Petty, M. Pharr, D. Pierce, C. Pierren, S. Pierson, A. Pigarov, L. Pigatto, D. Piglowski, S. Pinches, R. Pinsker, R. Pitts, J. Pizzo, M. Podesta, Z. Popovic, M. Porkolab, Q. Pratt, G. Prechel, I. Pusztai, P. Puthan-Naduvakkate, J. Qian, X. Qin, O. Ra, T. Raines, K. Rakers, K. Rath, J. Rauch, C. Rea, R. Reed, A. Reiman, M. Reinke, R. Reksoatmodjo, Q. Ren, J. Ren, Y. Ren, M. Rensink, T. Rhodes, N. Richner, J. Ridzon, G. Riggs, J. Riquezes, P. Rodriguez Fernandez, T. Rognlien, G. Ronchi, L. Rondini, R. Rosati, A. Rosenthal, M. Ross, J. Rost, A. Rothstein, J. Roveto, J. Ruane, D. Rudakov, R. Rupani, G. Rutherford, S. Sabbagh, J. Sachdev, N. Sadeghi, A. Salmi, F. Salvador, B. Sammuli, C. Samuell, A. Sandorfi, C. Sang, D. Santa, J. Sarff, O. Sauter, H. Savelli, C. Schaefer, H. Schamis, J. Schellpfeffer, D. Schissel, L. Schmitz, O. Schmitz, P. Schroeder, K. Schultz, E. Schuster, F. Sciortino, F. Scotti, J. Scoville, A. Seltzman, J. Seo, J. Serrano, I. Sfiligoi, M. Shafer, R. Shapov, H. Shen, N. Shi, D. Shiraki, B. Short, R. Shousha, H. Si, C. Sierra, G. Sinclair, P. Sinha, G. Sips, C. Skinner, T. Slendebroek, J. Slief, R. Smirnov, S. Smith, D. Smith, G. Snoep, P. Snyder, W. Solomon, X. Song, A. Sontag, V. Soukhanovskii, D. Spong, J. Squire, G. Staebler, L. Stagner, T. Stange, P. Stangeby, E. Starling, S. Stewart, T. Stoltzfus-Dueck, S. Storment, E. Strait, D. Su, L. Sugiyama, P. Sun, Y. Sun, X. Sun, C. Sung, W. Suttrop, Y. Suzuki, R. Sweeney, B. Taczak, Y. Takemura, S. Tang, W. Tang, G. Tardini, D. Taussig, K. Teixeira, K. Thackston, D. Thomas, K. Thome, Y. Tinguely, M. Tobin, J. Tooker, A. Torrezan de Sousa, P. Traverso, G. Trevisan, E. Trier, D. Truong, C. Tsui, F. Turco, A. Turnbull, L. Turner, E. Unterberg, B. Van Compernolle, R. van Kampen, M. Van Zeeland, B. Victor, R. Vieira, E. Viezzer, S. Vincena, D. Vollmer, J. Wai, M. Walker, R. Waltz, W. Wampler, L. Wang, Y. Wang, H. Wang, Z. Wang, G. Wang, A. Wang, J. Watkins, M. Watkins, T. Watts, L. Webber, K. Weber, W. Wehner, X. Wei, D. Weisberg, A. Welander, A. Welsh, A. White, R. Wilcox, G. Wilkie, T. Wilks, M. Willensdorfer, H. Wilson, A. Wingen, M. Wu, D. Wu, S. Wukitch, J. Xia, R. Xie, Z. Xing, G. Xu, X. Xu, Z. Yan, X. Yang, L. Yang, S. Yang, J. Yang, M. Yoo, G. YU, J. Yu, A. Zalzali, A. Zamengo, V. Zamkovska, S. Zamperini, K. Zarrabi, E. Zeger, K. Zeller, L. Zeng, X. Zhang, J. Zhang, B. Zhang, B. Zhao, C. Zhao, Y. Zheng, Y. Zhu, J. Zhu, J. Ziegel, J. Zimmerman, C. Zuniga

Publikováno v: Nuclear Fusion, Vol 64, Iss 11, p 112003 (2024)

The DIII-D tokamak has elucidated crucial physics and developed projectable solutions for ITER and fusion power plants in the key areas of core performance, boundary heat and particle transport, and integrated scenario operation, with closing the cor

Externí odkaz: https://doaj.org/article/8fa2aa8d5e7d4cf29013ade35184919c

Study protocol of a multiphase optimization strategy trial (MOST) for delivery of smoking cessation treatment in lung cancer screening settings

Autor: Jamie S. Ostroff, Donna R. Shelley, Lou-Anne Chichester, Jennifer C. King, Yuelin Li, Elizabeth Schofield, Andrew Ciupek, Angela Criswell, Rashmi Acharya, Smita C. Banerjee, Elena B. Elkin, Kathleen Lynch, Bryan J. Weiner, Irene Orlow, Chloé M. Martin, Sharon V. Chan, Victoria Frederico, Phillip Camille, Susan Holland, Jessica Kenney

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-16 (2022)

Abstract Background There is widespread agreement that the integration of cessation services in lung cancer screening (LCS) is essential for achieving the full benefits of LCS with low-dose computed tomography (LDCT). There is a formidable knowledge

Externí odkaz: https://doaj.org/article/b101fbe77a174b739b85d77e5adda5d9