Negative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis

Autor: Victoria Gudiño, Patrizia Cammareri, Caroline V. Billard, Kevin B. Myant

Publikováno v: Cell Death and Disease, Vol 12, Iss 10, Pp 1-12 (2021)

Abstract RAC1B is a tumour-related alternative splice isoform of the small GTPase RAC1, found overexpressed in a large number of tumour types. Building evidence suggests it promotes tumour progression but compelling in vivo evidence, demonstrating a

Externí odkaz: https://doaj.org/article/381b458820c14084a39556c04ee2ac1d

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

Autor: George Dickson, Linda Popplewell, Farhat V N Din, Adam E. Hall, Kevin Myant, Malcolm G. Dunlop, Paz Freile, Alfonso Bolado, Caroline V. Billard, Victoria Gudiño, Stuart Aitken, Mark Agostino, David A. Stevenson, Douglas Strathdee, Laura Murphy, Owen J. Sansom, Alex von Kriegsheim, Sebastian Öther-Gee Pohl, John W. Cassidy, Patrizia Cammareri, Colin Nixon, Ann P. Wheeler

Publikováno v: Nature Communications
Gudiño, V, Öther-Gee Pohl, S, V Billard, C, Cammareri, P, Bolado Carrancio, A, Aitken, S, Stevenson, D, Hall, A, Agostino, M, Cassidy, J, Nixon, C, von Kriegsheim, A, Friele, P, Popplewell, L, Dickson, G, Murphy, L, Wheeler, A P, Dunlop, M G, Din, F V N, Strathdee, D, J. Sansom, O & Myant, K B 2021, ' Rac1b modulates intestinal tumourigenesis via modulation of Wnt and Egfr signalling pathways ', Nature Communications . https://doi.org/10.1038/s41467-021-22531-3
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Current therapeutic options for treating colorectal cancer have little clinical efficacy and acquired resistance during treatment is common, even following patient stratification. Understanding the mechanisms that promote therapy resistance may lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d761f8e664c9c0e74b157a8fb7baff43
https://eprints.gla.ac.uk/239120/1/239120.pdf

Link between postoperative ileus and anastomotic leakage: A structural equation modelling approach

Autor: Aurélien Venara, Jean-Francois Hamel, Laura Beyer-Berjot, Timothée Vignaud, Karem Slim, M. Abderrazak, H. Abolo, N. Abras, M. Aissou, S. Albertini, P. Alfonsi, A. Andre, J.M. Arimont, L. Arnalsteen, J. Atger, A. Attias, O. Aumont, S. Auvray, R. Bachmann, G. Barabino, P. Barsotti, B. Beauchesne, N. Beaupel, A. Beliard, A. Bellouard, H. Beloeil, F. Ben Salem, A. Benhamou, V. Billard, M. Binhas, D. Binot, J.L. Blache, A. Blet, J.P. Bongiovanni, A. Bonnal, M. Bonnet, H. Boret, A.E. Bossard, H. Bothereau, N. Bouarroudj, A. Bouayed, F. Bouchard, M. Boumadani, M. Bousquet, V. Bouygues, G. Bozio, A. Brek, P. Cadi, P. Caillon, A. Camerlo, C. Capito, J.L. Cardin, M. Castiglioni, M.L. Catinois, P. Cattan, C. Chambrier, G. Chambrier, O. Chapuis, M. Chauvin, S. Chokairi, X. Chopin Laly, V. Collange, E. Cotte, E. Cuellar, E. D'errico, S. Dahmani, M. Danan, C. De La Fontaine, P. De Wailly, C. Degauque, F. Delacoste, C. Denet, Q. Denost, P. Desaint, E. Descamps, V Desfourneaux., J. Desmet, G. Desolneux, S. Dileon, J.B. Dolbeau, R. Douard, F. Dufour, E. Dupont-Bierre, A. Dupré, A. Entremont, J.L. Faucheron, P. Fernoux, S. Figuet, A. Finianos, R. Flamein, D. Fletcher, J.P. Fontes, E. Fourn, S. Gergeanu, A. Germain, B. Gignoux, P. Goater, P Gres., M. Grigoroiu, P. Grillo, B. Guignard, D. Guinier, J.L. Guiot, C. Gutton, H. Hadjadj, K. Hail, M.H. Hausermann, S. Hennequin, B. Homsy-Hubert, S. Jambet, T. Janecki, V. Jannier-Guillou, J. Jaspart, F. Joly, J. Joris, F. Journe, F. Kattou, G. Kemoun, M. Khalaf, F. Klack, K. Kothonidis, O. Kurdi, A. Laforest, A. Lamblin, S. Lammens, S. Laporte, M.V. Launay-Savary, A.L. Le Maho, J.M. Lemée, D. Leonard, J. Leporrier, J.L. Lorin, E. Magne, F. Maisonnette, V. Malherbe, G. Manceau, P. Mariani, D. Massalou, J.L. Massard, F. Mauvais, J. Mbuyamba, J. Mbuyamba Katapile, T. Mehila, H. Meillat, C. Mergui, P. Michaud, F. Milou, F. Mirre, C. Mor Martinez, S. Mouchon, F. Mouilhade, Y.L. Nguyen, S. Ostermann Bucher, M. Page, S. Parent, A.L. Payen, R. Pedicone, P. Peluchon, V. Pichot-Delahaye, A. Piquard, I. Pirlet, L. Plard, M. Poiblanc, G. Poinas, J. Poincenot, C. Ponchel, A. Pontallier, R. Pop, E. Potiron, J.M. Proske, B. Prunet, E. Ras, O. Raspado, M. Raux, J.M. Regimbeau, C. Remue, F. Renacco, R. Riboud, A.L. Richard-Payen, D. Rio, M. Sage, P.Y. Sage, M. Saint Denis, P. Salaun, B. Samyn, M. Sbai Idrissi, G. Schmitt, E. Secq, A. Seddiki, N. Sens, D. Sirieix, F. Siriser, M. Tarcea, M. Tavernier, B. Tete, O. Theissen-Laval, A. Thevenot, R. Thievenaz, B. Vacher, R. Verhaeghe, J.F. Verrier, C. Vieuille, C. Voilin, C. Vuagnat, S. Zaepfel

Publikováno v: Surgery Open Digestive Advance. 2:100009

Introduction Postoperative ileus(POI) and anastomotic leakage(AL) are highly associated but the direction of this link is unknown. Indeed, it has traditionally been stated that AL leads to POI(secondary POI). The objective was to statistically determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8017366969ee03f3f8a359108bdbd3e1
https://doi.org/10.1016/j.soda.2021.100009

P036 A novel p53-mediated mouse model of inflammatory bowel disease-associated colorectal cancer

Autor: C V Billard, Mark J. Arends, A M Churchhouse, K B Myant

Publikováno v: Journal of Crohn's and Colitis. 14:S150-S150

Background Current mouse models of colitis-associated cancer often utilise a combination of APC mutation, Dextran sulphate sodium (DSS) and azoxymethane administration. However, only 13% of human inflammatory bowel disease (IBD)-associated cancers is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43c22784c32043afd88c509e29800b61
https://doi.org/10.1093/ecco-jcc/jjz203.165

Fibre-optic intubation teaching in sedated patients with anticipated difficult intubation

Autor: G. Gueret, V. Billard, Jean-Louis Bourgain

Publikováno v: European Journal of Anaesthesiology. 24:239-244

Background and objectivesThe objective of the study was to assess the safety of training fibre-optic intubation performed under propofol light general anaesthesia in patients with an anticipated difficult intubation.MethodsPatients with ear, nose and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb4091784268da67b9c236be94b5f5e
https://doi.org/10.1017/s0265021506001475