Výsledky vyhledávání

D2 Dopaminergic Receptors: Normal and Abnormal Transduction Mechanisms

Autor: P. Jaquet, L. Caccavelli, I. Pellegrini, Alain Enjalbert, V Audinot, Cussac D

Publikováno v: Hormone Research. 38:78-83

Dopamine receptors of D2 type present on lactotroph cells are coupled to a large series of transduction mechanisms. Beside their negative coupling with adenylate cyclase, they are also coupled with potassium and calcium channels, leading to a decreas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e546b73fe84c711613ef59b2c27f0a3f
https://doi.org/10.1159/000182494

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Akademický článek

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Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization

Autor: M J, Millan, A, Newman-Tancredi, S, Lochon, M, Touzard, S, Aubry, V, Audinot

Publikováno v: Pharmacology, biochemistry, and behavior. 71(4)

Although several tritiated agonists have been used for radiolabelling serotonin (5-hydroxytryptamine, 5-HT)(1B) receptors in rats, data with a selective, radiolabelled antagonist have not been presented. Inasmuch as [3H]GR125,743 specifically labels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f87e475979175d1a0b79c5af363a033
https://pubmed.ncbi.nlm.nih.gov/11888550

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S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626

Autor: M J, Millan, A, Gobert, A, Newman-Tancredi, F, Lejeune, D, Cussac, J M, Rivet, V, Audinot, T, Dubuffet, G, Lavielle

Publikováno v: The Journal of pharmacology and experimental therapeutics. 293(3)

The benzopyranopyrrole S33084 displayed pronounced affinity (pK(i) = 9.6) for cloned human hD(3)-receptors, and100-fold lower affinity for hD(2) and all other receptors (30) examined. S33084 concentration dependently, potently, and competitively (pA(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1774dfd95ad43a9730b2ae4524d3ef21
https://pubmed.ncbi.nlm.nih.gov/10869410

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Activation of dopamine D(3) receptors induces c-fos expression in primary cultures of rat striatal neurons

Autor: B J, Morris, A, Newman-Tancredi, V, Audinot, C S, Simpson, M J, Millan

Publikováno v: Journal of neuroscience research. 59(6)

A modulation of the expression of immediate-early genes (IEGs) such as c-fos is likely involved in the long-term influence of dopaminergic ligands on the activity of basal ganglia neurons. The roles of individual dopamine receptor types in this regar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::438ba8c85c51eba8a1ea0fac7e83c97a
https://pubmed.ncbi.nlm.nih.gov/10700011

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S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multiparametric comparison with haloperidol, clozapine, and 11 other antipsychotic agents

Autor: M J, Millan, M, Brocco, J M, Rivet, V, Audinot, A, Newman-Tancredi, L, Maiofiss, S, Queriaux, N, Despaux, J L, Peglion, A, Dekeyne

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(1)

S18327 was dose-dependently active in several models of potential antipsychotic activity involving dopaminergic hyperactivity: inhibition of apomorphine-induced climbing in mice, of cocaine- and amphetamine-induced hyperlocomotion in rats, and of con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7463c54bbf7a554a5a976e33438c97e9
https://pubmed.ncbi.nlm.nih.gov/10604931

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Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5-HT2A sites for PCP-induced locomotion in the rat

Autor: M J, Millan, M, Brocco, A, Gobert, F, Joly, K, Bervoets, J, Rivet, A, Newman-Tancredi, V, Audinot, S, Maurel

Publikováno v: The European journal of neuroscience. 11(12)

In the present study, the comparative mechanisms of action of phencyclidine (PCP) and amphetamine were addressed employing the parameter of locomotion in rats. PCP-induced locomotion (PLOC) was potently blocked by the selective serotonin (5-HT)2A vs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5157100328f40daea058df9b813c310
https://pubmed.ncbi.nlm.nih.gov/10594669

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G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study

Autor: A, Newman-Tancredi, D, Cussac, V, Audinot, V, Pasteau, S, Gavaudan, M J, Millan

Publikováno v: Molecular pharmacology. 55(3)

Despite extensive study, the G protein coupling of dopamine D3 receptors is poorly understood. In this study, we used guanosine-5'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding to investigate the activation of G proteins coupled to human (h)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd96a4f7fb24249dcead370701a74d2c
https://pubmed.ncbi.nlm.nih.gov/10051542

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A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194

Autor: V, Audinot, A, Newman-Tancredi, A, Gobert, J M, Rivet, M, Brocco, F, Lejeune, L, Gluck, I, Desposte, K, Bervoets, A, Dekeyne, M J, Millan

Publikováno v: The Journal of pharmacology and experimental therapeutics. 287(1)

The benzofurane (+)-S 14297, the benzamide nafadotride, the aminoindane U 99194 and the arylpiperazine GR 103,691 have been proposed as "selective" antagonists at dopamine D3 vs. D2 receptors. Herein, we compared their in vitro affinities and in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b20b9fcaabda68cea4099ccfdd016f4c
https://pubmed.ncbi.nlm.nih.gov/9765337

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