Apixaban dosing in hemodialysis - can drug level monitoring mitigate controversies?

Autor: Simeon Schietzel, Andreas Limacher, Matthias B. Moor, Cecilia Czerlau, Uyen Huynh-Do, Bruno Vogt, Fabienne Aregger, Dominik E. Uehlinger

Publikováno v: BMC Nephrology, Vol 25, Iss 1, Pp 1-11 (2024)

Abstract Background Inconsistent study results and contradictory recommendations from health authorities regarding the use of apixaban in patients on hemodialysis have generated considerable uncertainty among clinicians, making investigations of appr

Externí odkaz: https://doaj.org/article/f7e135d418084d8bb1e842a96a6eb09e

Magnesium matters: unveiling hidden risks in kidney transplant patients through total and ionized magnesium profiling

Autor: Federica Bocchi, Simeon Schietzel, Uyen Huynh-Do, Bruno Vogt, Daniel Sidler

Publikováno v: Frontiers in Nephrology, Vol 4 (2024)

BackgroundIn kidney transplant (KT) patients, magnesium (Mg2+) deficiency is widespread. It is often encountered early after KT, may persist longer, and is frequently promoted by calcineurin inhibitors (CNIs) and tubular leakage. Studies demonstrated

Externí odkaz: https://doaj.org/article/741b388ccd4c433dbe31ca1e317e6818

Frequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species

Autor: Jakob E. Brune, Michael Dickenmann, Daniel Sidler, Laura N. Walti, Déla Golshayan, Oriol Manuel, Fadi Haidar, Dionysios Neofytos, Aurelia Schnyder, Katia Boggian, Thomas F. Mueller, Thomas Schachtner, Nina Khanna, Stefan Schaub, Caroline Wehmeier, the Swiss Transplant Cohort Study, Patrizia Amico, John-David Aubert, Adrian Bachofner, Vanessa Banz, Sonja Beckmann, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Annalisa Berzigotti, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Anne Cairoli, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Sophie De Seigneux, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Sylvie Ferrari-Lacraz, Jaromil Frossard, Christian Garzoni, Nicolas Goossens, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Linard Hoessly, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller, Andreas Kremer, Christian Kuhn, Bettina Laesser, Frédéric Lamoth, Roger Lehmann, Alexander Leichtle, Hans-Peter Marti, Michele Martinelli, Valérie McLin, Katell Mellac, Aurélia Merçay, Karin Mettler, Nicolas Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual, Jakob Passweg, Rosemarie Pazeller, Klara Posfay-Barbe, David Reineke, Juliane Rick, Anne Rosselet, Simona Rossi, Rössler, Silvia Rothlin, Frank Ruschitzka, Alexandra Scherrer, Dominik Schneidawind, Macé Schuurmans, Simon Schwab, Thierry Sengstag, Federico Simonetta, Jürg Steiger, Guido Stirniman, Ueli Stürzinger, Christian Van Delden, Jean-Pierre Venetz, Jean Villard, Julien Vionnet, Madeleine Wick, Markus Wilhlem, Patrick Yerly

Publikováno v: Frontiers in Medicine, Vol 11 (2024)

BackgroundEnterobacterales are often responsible for urinary tract infection (UTI) in kidney transplant recipients. Among these, Escherichia coli or Klebsiella species producing extended-spectrum beta-lactamase (ESBL) are emerging. However, there are

Externí odkaz: https://doaj.org/article/8a2807b2ba0b4fa9a10786acd1fc2ce2

Recurrence of IgA nephropathy after kidney transplantation: experience from the Swiss transplant cohort study

Autor: Cédric Jäger, Susanne Stampf, Karen Molyneux, Jonathan Barratt, Déla Golshayan, Karine Hadaya, Uyen Huynh-Do, Francoise-Isabelle Binet, Thomas F Mueller, Michael Koller, Min Jeong Kim

Publikováno v: BMC Nephrology, Vol 23, Iss 1, Pp 1-11 (2022)

Abstract Background Recurrence of IgA nephropathy (IgAN) after kidney transplantation occurs in about 30% of patients. The relevance of recurrence for the long-term graft survival is expected to increase, since graft survival continues to improve. Me

Externí odkaz: https://doaj.org/article/112a9755359342f597fffb94c43f12b3

The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation – Data from the Swiss transplant cohort study

Autor: Lukas Frischknecht, Yun Deng, Caroline Wehmeier, Olivier de Rougemont, Jean Villard, Sylvie Ferrari-Lacraz, Déla Golshayan, Monique Gannagé, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson, the Swiss Transplant Cohort Study, Patrizia Amico, Andres Axel, John David Aubert, Vanessa Banz, Beckmann Sonja, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Thierry Carrel, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Olivier De Rougemont, Michael Dickenmann, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Nicola Franscini, Christian Garzoni, Paola Gasche Soccal, Christophe Gaudet, Nicolas Goossens, Karine Hadaya, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller (Head of the data center), Mirjam. Laager, Bettina Laesser, Roger Lehmann, Alexander Leichtle, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Yves Martin, Michele Martinelli, Valérie McLin, Katell Mellac, Aurelia Mercay, Karin Mettler, Nicolas Mueller (Chairman Scientific Committee), Antonia Müller, Thomas Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual (Executive office), Klara Posfay-Barbe, Juliane Rick, Anne Rosselet, Simona Rossi, Silvia Rothlin, Frank Ruschitzka, Urs Schanz, Aurelia Schnyder, Macé Schuurmans, Thierry Sengstag, Federico Simonetta, Katharina Staufer, Susanne Stampf, Jürg Steiger (Head, Excecutive office), Guido Stirniman, Ueli Stürzinger, Christian Van Delden (Executive office), Jean-Pierre Venetz, Julien Vionnet,Madeleine Wick (STCS coordinator), Markus Wilhlem, Patrick Yerly

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundPre-transplant donor specific antibodies (DSA), directed at non-self human leukocyte antigen (HLA) protein variants present in the donor organ, have been associated with worse outcomes in kidney transplantation. The impact of the mean fluor

Externí odkaz: https://doaj.org/article/d4470ae796694141bd821317fd2f95c7