Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies.

Autor: Galasiti Kankanamalage AC; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States., Kim Y, Weerawarna PM; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States., Uy RA; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States., Damalanka VC; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States., Mandadapu SR; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States., Alliston KR; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States., Mehzabeen N; §Protein Structure Laboratory,The University of Kansas, Lawrence, Kansas 66047, United States., Battaile KP; ∥IMCA-CAT, Hauptman-Woodward Medical Research Institute, APS Argonne National Laboratory, Argonne, Illinois 60439, United States., Lovell S; §Protein Structure Laboratory,The University of Kansas, Lawrence, Kansas 66047, United States., Chang KO, Groutas WC; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Apr 09; Vol. 58 (7), pp. 3144-55. Date of Electronic Publication: 2015 Mar 19.

Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.

Autor: Mandadapu SR; Department of Chemistry, Wichita State University, Wichita, KS 67260, USA., Gunnam MR, Galasiti Kankanamalage AC, Uy RA, Alliston KR, Lushington GH, Kim Y, Chang KO, Groutas WC

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Nov 01; Vol. 23 (21), pp. 5941-4. Date of Electronic Publication: 2013 Aug 22.

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.

Autor: Mandadapu SR; Department of Chemistry, Wichita State University, Wichita, KS 67260, USA., Weerawarna PM, Prior AM, Uy RA, Aravapalli S, Alliston KR, Lushington GH, Kim Y, Hua DH, Chang KO, Groutas WC

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Jul 01; Vol. 23 (13), pp. 3709-12. Date of Electronic Publication: 2013 May 16.