Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Uwe Wollert"'
Publikováno v:
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 62:101-105
1. The stereospecificity of the interaction of the enantiomers of the anticoagulent drugs warfarin and phenprocoumon with bovine and rat serum albumin was investigated using equilibrium dialysis and circular dichroism measurements and compared with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a046b4a45169dca68df3728b7132e9
https://doi.org/10.1016/0306-4492(79)90107-2
https://doi.org/10.1016/0306-4492(79)90107-2
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 319:172-177
Receptor binding studies were performed with tritiated propyl β-carboline-3-carboxylate ([3H]PrCC), tritiated ethyl β-carboline-3-carboxylate ([3H]ECC), and tritiated flunitrazepam ([3H]FNT) in membrane preparations from different regions of the bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f623e0ba97e5df2db14177e0233db6f
https://doi.org/10.1007/bf00503933
https://doi.org/10.1007/bf00503933
Autor:
Walter E. Müller, Uwe Wollert
Publikováno v:
Biochemical Pharmacology. 25:141-145
The binding of eleven benzodiazepine derivatives to bovine serum albumin was determined by means of Sephadex gel filtration. The albumin binding of the substances was characterized by the percentage of drug bound, the binding constants k + , K 1 , an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edecab85964374ea763d06712fc37c4c
https://doi.org/10.1016/0006-2952(76)90281-1
https://doi.org/10.1016/0006-2952(76)90281-1
Autor:
Uwe Wollert, Walter E. Müller
Publikováno v:
Biochemical Pharmacology. 25:1459-1464
The interaction of four sulfonamides with bovine and human serum albumin (BSA and HSA) was investigated by means of circular dichroism and u.v. absorbance measurements. In the case of all sulfonamides, extrinsic Cotton effects could be found for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea29c034da26a8f7ae56453af1d78dfd
https://doi.org/10.1016/0006-2952(76)90061-7
https://doi.org/10.1016/0006-2952(76)90061-7
Autor:
Hans Rommelspacher, Harald Borbe, Uwe Wollert, Walter E. Müller, Klaus J. Fehske, Christel Nanz
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 314:97-100
The interaction of several beta-carbolines with specific [3H]-flunitrazepam binding to benzodiazepine receptors in rat brain membranes was investigated. Out of the investigated compounds, harmane and norharmane were the most potent inhibitors of spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f1e959a6b8ac16e8c37df6b49b9220
https://doi.org/10.1007/bf00498436
https://doi.org/10.1007/bf00498436
Publikováno v:
Neuroscience Letters. 9:239-243
Using [ 3 H]diazepam, benzodiazepine receptor binding has been investigated in rat spinal cord synaptosomal membranes. Specific [ 3 H]diazepam binding is saturable with a K D of about 8 nM and a maximal number of binding sites of 0.48 pmol/mg protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfeb0be415d644516c1374492224e69
https://doi.org/10.1016/0304-3940(78)90079-4
https://doi.org/10.1016/0304-3940(78)90079-4
Publikováno v:
Neuropharmacology. 19:121-124
The interaction of several central nervous system stimulating and depressing drugs with specific [3H]flunitrazepam binding to benzodiazepine receptors in rat brain membranes was investigated. Most of the investigated intravenous anesthetics, hypnotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7aaca03da24e8da8265a7e08ae8715
https://doi.org/10.1016/0028-3908(80)90176-8
https://doi.org/10.1016/0028-3908(80)90176-8
Autor:
Uwe Wollert, Walter E. Müller
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure. 427:465-480
The binding of suramin to bovine and human serum albumin was investigated by gel filtration and spectroscopic measurements. Besides some low-affinity binding sites suramin has, on the bovine serum albumin molecule one and on the human serum albumin m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2260a474a43356deabae061d97bb465
https://doi.org/10.1016/0005-2795(76)90189-6
https://doi.org/10.1016/0005-2795(76)90189-6
Autor:
Walter E. Müller, Uwe Wollert
Publikováno v:
Pharmacology. 19:59-67
Most drugs are bound to human serum albumin (HSA) via a few high affinity binding sites and several sites of much lower affinity. There is now increasing evidence that the actual number of high affinity drug-binding sites of HSA is rather small. Thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60d4acfc56b6c90e38c5ea2d016a4524
https://doi.org/10.1159/000137289
https://doi.org/10.1159/000137289
Autor:
Walter E. Müller, Uwe Wollert
Publikováno v:
Biochemical Pharmacology. 25:147-152
The interaction of benzodiazepine derivatives with bovine serum albumin (BSA) was studied by circular dichroism (CD) measurements. Most of the investigated benzoidiazepines show biphasic extrinsic Cotton effects, which are largely influenced by raisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f05d38af55dee425339f7de394ace6
https://doi.org/10.1016/0006-2952(76)90282-3
https://doi.org/10.1016/0006-2952(76)90282-3