Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Uwe Ries"'
Autor:
Nathan K. Yee, Shengli Ma, Joshua D. Sieber, Bo Qu, Jean-Nicolas Desrosiers, Nizar Haddad, Nelu Grinberg, Uwe Ries, Heewon Lee, Yongda Zhang, Nitinchandra D. Patel, Sonia Rodriguez, Chris H. Senanayake
Publikováno v:
The Journal of organic chemistry. 81(3)
An efficient synthesis of the enantiomerically pure 3,3'-bis-arylated BINOL derivatives is accomplished through the palladium-catalyzed Suzuki-Miyaura coupling of the unprotected 3,3'-dibromo-BINOL with complete retention of enantiopurity. The active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c3e89ea5f47259f418f7dc41707e9e
https://pubmed.ncbi.nlm.nih.gov/26756863
https://pubmed.ncbi.nlm.nih.gov/26756863
Autor:
Uwe Ries, Herbert Nar, Wolfgang Wienen, Henning Priepke, Eric E. J. Haaksma, Jean Marie Stassen, Norbert Hauel
Publikováno v:
Ries, U J, Priepke, H W, Hauel, N H, Haaksma, E J J, Stassen, J M, Wienen, W & Nar, H 2003, ' Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives ', Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 14, pp. 2291-5 . https://doi.org/10.1016/S0960-894X(03)00442-6
Bioorganic and Medicinal Chemistry Letters, 13(14), 2291-5. Elsevier Limited
Bioorganic and Medicinal Chemistry Letters, 13(14), 2291-5. Elsevier Limited
Amidino-phenoxy quinoline derivatives represent a new class of potent thrombin inhibitors with good selectivity and remarkably low molecular weight ( M W : 335–391). X-ray analyses of thrombin-bound inhibitors revealed that enzyme inhibition is mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7373e16633c6d1d3998838a3692b73dd
https://doi.org/10.1016/s0960-894x(03)00442-6
https://doi.org/10.1016/s0960-894x(03)00442-6
Autor:
Joerg Kley, Uwe Ries, Herbert Nar, Paul Declerck, Ann Gils, Wolfgang Wienen, Jean-Marie Stassen
Publikováno v:
Thrombosis and Haemostasis. 88:137-143
SummaryPlasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor of both tissue-type plasminogen activator and urokinasetype plasminogen activator in plasma, is a well established risk factor in thrombotic diseases. Reduction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c081128d7d01923c6a62f77822dcd4
https://doi.org/10.1055/s-0037-1613166
https://doi.org/10.1055/s-0037-1613166
Autor:
Uwe Ries, Jean-Marie Stassen, Angela Schmid, Norbert Hauel, Herbert Nar, Iris Kauffmann, Wolfgang Wienen, Henning Priepke, Margit Bauer
Publikováno v:
Structure. 9:29-37
Background: A major current focus of pharmaceutical research is the development of selective inhibitors of the blood coagulation enzymes thrombin or factor Xa to be used as orally bioavailable anticoagulant drugs in thromboembolic disorders and in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f31a886e572dbd10eeacdcdd3ba65a
https://doi.org/10.1016/s0969-2126(00)00551-7
https://doi.org/10.1016/s0969-2126(00)00551-7
Autor:
Norbert Hauel, Wolfgang Wienen, Jacobus C. A. Van Meel, Berthold Narr, Kai M. Hasselbach, Uwe Ries, Helmut Wittneben, Gerhard Mihm, Michael Entzeroth
Publikováno v:
Journal of Medicinal Chemistry. 36:4040-4051
Starting from the recently reported nonpeptidic angiotensin II (AII) receptor antagonists DuP753 (1) and Exp 7711 (2), we have designed and investigated novel substituted benzimidazoles. Systemic variation of several substituents at the benzimidazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ead8ec4cc65146e06e80b97c72a90a
https://doi.org/10.1021/jm00077a007
https://doi.org/10.1021/jm00077a007
Autor:
Herbert Nar, Uwe Ries, Wolfgang Wienen, Henning Priepke, Sandra Handschuh, Gerhard Mihm, Jean Marie Stassen, Norbert Hauel
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(14)
Quinoxalinone derivatives as prototypes of dual thrombin and factor Xa inhibitors have been discovered. Nanomolar inhibition of both coagulation enzymes resulted in very potent antithrombotic activity in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7307e01ec4e3529e8580b1a73516360
https://pubmed.ncbi.nlm.nih.gov/12824021
https://pubmed.ncbi.nlm.nih.gov/12824021
Autor:
Jean Stassen, Uwe Ries
Publikováno v:
Current Medicinal Chemistry. 11:i-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e77d81d9e94c1af474791916efca6654
https://doi.org/10.2174/0929867043364577
https://doi.org/10.2174/0929867043364577
Autor:
Wolfgang Wienen, Uwe Ries
Publikováno v:
Drugs of the Future. 28:0355
Pathological activation of the hemostatic system, resulting in thromboembolic complications, is a major cause of morbidity and mortality. Unfractionated heparins and low-molecular-weight heparins, both suitable only for parenteral administration, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ff39dd28b1271d785b19fa53d9fffa
https://doi.org/10.1358/dof.2003.028.04.729682
https://doi.org/10.1358/dof.2003.028.04.729682