Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Uwe Niesner"'
Publikováno v:
Zeitschrift für Rheumatologie. 67:684-688
State-of-the-art immunosuppressive therapies, though efficient in the treatment of rheumatic inflammatory disorders, in most cases do not provide a cure. Complete immunablation and the associated deletion of the reactive immunological memory followed
Autor:
Alexander Scheffold, Thomas Häupl, Ahmed N. Hegazy, Orhan Aktas, J. Sieper, Michal Janitz, Stephan Kreher, Philipp Enghard, Sina Bartfeld, Cornelia Doebis, Alf Hamann, Juliana Koeck, Inna Gitelman, Marko Janke, Katharina Eulenburg, Gerd R Burmester, Martin Zeitz, Ria Baumgrass, Frauke Zipp, Thomas Kamradt, Rainer Duchmann, Joachim Gruen, Jens Y Humrich, Ulf Schulze-Topphoff, Martin Rudwaleit, Veit Krenn, Daniel C. Baumgart, Kerstin Bonhagen, Christoph Loddenkemper, Uwe Niesner, Max Löhning, Maria H. Lexberg, Bertram Wiedenmann, Inka Albrecht, Hyun D. Chang, Helena Radbruch, Andreas Radbruch, Sascha Rutz
Publikováno v:
The Journal of Experimental Medicine
The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor kappaB (NF-kappaB)-dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology. We show that twist1 is expressed
Autor:
Christophe Pannetier, Max Löhning, Petra Hajkova, Jörn Walter, Osman Sozeri, Torsten Stamm, Uwe Niesner, Jane Hu-Li, Stephan Kreher, Andreas Radbruch, William E. Paul, Beate Friedrich, Lars-Oliver Tykocinski, Hyun-Dong Chang, Gerald Grütz
Publikováno v:
Journal of Biological Chemistry. 280:28177-28185
Naive T helper (Th) lymphocytes are induced to express the il4 (interleukin-4) gene by simultaneous signaling through the T cell receptor and the interleukin (IL)-4 receptor. Upon restimulation with antigen, such preactivated Th lymphocytes can reexp
Autor:
Jochen Huehn, Uta Haubold, Uwe Niesner, Alf Hamann, Grzegorz K. Przybylski, Alexander Scheffold, Rolf Bräuer, Christiane Siewert, Joerg Lauber, Gudrun F. Debes, Kerstin Siegmund, Joachim C. U. Lehmann, Christian Schmidt, Markus Feuerer, Jan Buer, Maurus de la Rosa, Oliver Frey
Publikováno v:
The Journal of Experimental Medicine
Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental
Autor:
Joachim R. Kalden, Andreas Radbruch, Uwe Niesner, Alla Skapenko, Rolf Beetz, Jan Leipe, Peter E. Lipsky, Hendrik Schulze-Koops, Koen Devriendt
Publikováno v:
The Journal of Experimental Medicine
The delineation of the in vivo role of GATA-3 in human T cell differentiation is a critical step in the understanding of molecular mechanisms directing human immune responses. We examined T cell differentiation and T cell–mediated effector function
Autor:
Claudia Berger, Uwe Niesner
Publikováno v:
Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d56ef33c3f165e172df84c7e3c86ab1
https://doi.org/10.1002/9781118075685.ch20
https://doi.org/10.1002/9781118075685.ch20
Autor:
Anja A. Kühl, Jonathan A. Epstein, Uwe Niesner, Maria H. Lexberg, Joachim R. Grün, Koji Tokoyoda, Andreas Radbruch, Hyun-Dong Chang, Kristyna Hradilkova, Christoph Loddenkemper, Alf Hamann, Marko Janke, Astrid Menning, Inga Lepenies, Kerstin Westendorf, Inka Albrecht
Publikováno v:
European journal of immunology. 40(11)
Th1 cells are prominent in inflamed tissue, survive conventional immunosuppression, and are believed to play a pivotal role in driving chronic inflammation. Here, we identify homeobox only protein (Hopx) as a critical and selective regulator of the s
Autor:
Hyun-Dong Chang, Torsten Zuberbier, Uwe Niesner, Ulrich Zügel, Andreas Steinmeyer, Guido Heine, Margitta Worm, Andreas Radbruch
Publikováno v:
European journal of immunology. 38(8)
1,25-dihydroxyvitamin D(3) (calcitriol) regulates immune responses, e.g., inhibits expression of IgE by B cells and enhances expression of IL-10 by dendritic cells and T cells. We report here that activation of human B cells by B cell receptor, CD40
Autor:
Stephan Kreher, Christina Helbig, Lars Oliver Tykocinski, Juliana Koeck, Uwe Niesner, Hyun-Dong Chang, Andreas Radbruch
Publikováno v:
European journal of immunology. 37(3)
In Th1 and Th2 memory lymphocytes, the genes for the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) are imprinted for expression upon restimulation. This cytokine memory is based on expression of the transcription factors T-bet for IFN
Publikováno v:
Immunotherapy in 2020 ISBN: 9783540708506
Current therapeutic options that are based on immunosuppression do not provide a cure for the treatment of chronic inflammation. Though more efficient immunosuppression and the introduction of biologicals such as antibodies targeting cytokines have i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd80e924a18f49bb28d4bb7f4b6e1001
https://doi.org/10.1007/2789_2007_037
https://doi.org/10.1007/2789_2007_037