Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Uwe Liebchen"'
Autor:
Helen Graf, Caroline Gräfe, Mathias Bruegel, Felix L. Happich, Vassilissa Wustrow, Aljoscha Wegener, Wolfgang Wilfert, Michael Zoller, Uwe Liebchen, Michael Paal, Christina Scharf
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 9, Pp 2089-2101 (2024)
Abstract Introduction The release of pro-inflammatory cytokines in critically ill patients with sepsis leads to endothelial dysfunction resulting in cardiocirculatory insufficiency. Their extracorporeal elimination using the cytokine adsorber CytoSor
Externí odkaz:
https://doaj.org/article/143819681fb243d69786ff613a62babd
Autor:
Diana Rebholz, Uwe Liebchen, Michael Paal, Michael Vogeser, Johannes Starp, Caroline Gräfe, Clara I. Brozat, Felix L. Happich, Katharina Habler, Christina Scharf
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-7 (2024)
Abstract Background Therapeutic drug monitoring (TDM) of anti-infectives such as linezolid is routinely performed in blood of intensive care unit (ICU) patients to optimize target attainment. However, the concentration at the site of infection is con
Externí odkaz:
https://doaj.org/article/0f2b854c2b2b400595ece88689fd2b84
Autor:
Antonia Greimel, Katharina Habler, Caroline Gräfe, Nils Maciuga, Clara Isabell Brozat, Michael Vogeser, Michael Zoller, Felix L. Happich, Uwe Liebchen, Sandra Frank, Michael Paal, Christina Scharf
Publikováno v:
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Background The release of toxic bile acids (BAs) in the blood of critically ill patients with cholestatic liver dysfunction might lead to the damage of various organs. Their extracorporeal elimination using the cytokine adsorber Cytosorb® (
Externí odkaz:
https://doaj.org/article/81795b989bbf4ba3a0fc1bb44fb81816
Autor:
Hannah Kipka, Uwe Liebchen, Max Hübner, Georg Höfner, Otto Frey, Klaus T. Wanner, Erich Kilger, Christian Hagl, Roland Tomasi, Hanna Mannell
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundThe inotropic drug levosimendan is often used off-label perioperatively in cardiac surgery patients with cardiopulmonary bypass (CPB). Data regarding serum concentrations of levosimendan and its metabolites within this context is lacking.Me
Externí odkaz:
https://doaj.org/article/11983f42dde040bb85cd8b99de014085
Autor:
Caroline Gräfe, Uwe Liebchen, Antonia Greimel, Nils Maciuga, Mathias Bruegel, Michael Irlbeck, Lorenz Weidhase, Michael Zoller, Michael Paal, Christina Scharf
Publikováno v:
Renal Failure, Vol 45, Iss 2 (2023)
Severe rhabdomyolysis frequently results in acute kidney injury (AKI) due to myoglobin accumulation with the need of kidney replacement therapy (KRT). The present study investigated whether the application of Cytosorb® (CS) led to an increased rate
Externí odkaz:
https://doaj.org/article/0c4648b2a6f743d99fe093eedc9a5a10
Autor:
Bettina Leber, Uwe Liebchen, Lisa Rohrhofer, Jennifer Weber, Teresa Klaus, Joerg Scheier, Robert Sucher, Philipp Stiegler
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionHemoadsorption shows promising signals in organ preservation and post lung transplantation. However, its potential impact on the pharmacokinetics of immunosuppressant drugs (ID) is still unknown.MethodsIn this interventional study, CytoSo
Externí odkaz:
https://doaj.org/article/c2f7744fb3264871addd8cdbe1b1055a
Autor:
Christina Scharf, Ferdinand Weinelt, Ines Schroeder, Michael Paal, Michael Weigand, Michael Zoller, Michael Irlbeck, Charlotte Kloft, Josef Briegel, Uwe Liebchen
Publikováno v:
Annals of Intensive Care, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Background Hemadsorption of cytokines is used in critically ill patients with sepsis or septic shock. Concerns have been raised that the cytokine adsorber CytoSorb® unintentionally adsorbs vancomycin. This study aimed to quantify vancomycin
Externí odkaz:
https://doaj.org/article/9b5936fe34104c658ef6aa3318deb7eb
Autor:
Uwe Liebchen, Hanna Salletmeier, Simon Kallee, Christina Scharf, Lucas Huebner, Alexandra Weber, Michael Zoller
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract The aim of this study was to investigate optimal loading doses prior to continuous infusion of meropenem in critically ill patients. A previously published and successfully evaluated pharmacokinetic model of critically ill patients was used
Externí odkaz:
https://doaj.org/article/35be4501d4fa47959d11c96691e45305
Autor:
Ute Chiriac, Daniel Richter, Otto R. Frey, Anka C. Röhr, Sophia Helbig, Stefan Hagel, Uwe Liebchen, Markus A. Weigand, Alexander Brinkmann
Publikováno v:
Antibiotics, Vol 12, Iss 7, p 1112 (2023)
Various studies have reported insufficient beta-lactam concentrations in critically ill patients. The optimal dosing strategy for beta-lactams in critically ill patients, particularly in septic patients, is an ongoing matter of discussion. This retro
Externí odkaz:
https://doaj.org/article/5689093f639e4ab4a532bf7386c1ddbf
Autor:
Christina Scharf, Ines Schroeder, Michael Paal, Martin Winkels, Michael Irlbeck, Michael Zoller, Uwe Liebchen
Publikováno v:
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Background A cytokine storm is life threatening for critically ill patients and is mainly caused by sepsis or severe trauma. In combination with supportive therapy, the cytokine adsorber Cytosorb® (CS) is increasingly used for the treatment
Externí odkaz:
https://doaj.org/article/238ccacb2bb5491e97a9b9fb1a71a204