Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Uwe Jerke"'
Autor:
Lovis Kling, Claudia Eulenberg-Gustavus, Uwe Jerke, Anthony Rousselle, Kai-Uwe Eckardt, Adrian Schreiber, Ralph Kettritz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
During inflammation, human neutrophils engage β2-integrins to migrate from the blood circulation to inflammatory sites with high cytokine but low oxygen concentrations. We tested the hypothesis that the inhibition of prolyl hydroxylase domain-contai
Externí odkaz:
https://doaj.org/article/e21547a5b076437686abf3b1f75ddd24
Autor:
Maximilian Ebert, Uwe Jerke, Claudia Eulenberg-Gustavus, Lovis Kling, Dieter Jenne, Marieluise Kirchner, Philipp Mertins, Markus Bieringer, Saban Elitok, Kai-Uwe Eckardt, Adrian Schreiber, Alan D. Salama, Ralph Kettritz
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Background Antineutrophil cytoplasmic autoantibody–associated (ANCA-associated) vasculitidies (AAV) are life-threatening systemic autoimmune conditions. ANCAs directed against proteinase 3 (PR3) or myeloperoxidase (MPO) bind their cell surface-pres
Externí odkaz:
https://doaj.org/article/9c5f2d75f15f4b508c8edb2149fdceb8
Autor:
Uwe Jerke, Sergey Tkachuk, Julia Kiyan, Victoria Stepanova, Angelika Kusch, Michael Hinz, Rainer Dietz, Hermann Haller, Bianca Fuhrman, Inna Dumler
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8302 (2009)
BACKGROUND:Members of the signal transducer and activator of transcription (Stat) family of transcription factors traverse the nuclear membrane through a specialized structure, called the nuclear pore complex (NPC), which represents a selective filte
Externí odkaz:
https://doaj.org/article/faa4eeef3dbd431c8303e80f4f9f83fc
Autor:
Uwe Jerke, Claudia Eulenberg-Gustavus, Anthony Rousselle, Paul Nicklin, Stefan Kreideweiss, Marc A. Grundl, Peter Eickholz, Katrin Nickles, Adrian Schreiber, Brice Korkmaz, Ralph Kettritz
Publikováno v:
J Am Soc Nephrol
BACKGROUND: The ANCA autoantigens proteinase 3 (PR3) and myeloperoxidase (MPO) are exclusively expressed by neutrophils and monocytes. ANCA-mediated activation of these cells is the key driver of the vascular injury process in ANCA-associated vasculi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc0bb09b8c21cc8e3631084260eb3df
https://doi.org/10.1681/asn.2021081112
https://doi.org/10.1681/asn.2021081112
Publikováno v:
The Journal of biological chemistry. 298(3)
CD177 is a neutrophil-specific receptor presenting the proteinase 3 (PR3) autoantigen on the neutrophil surface. CD177 expression is restricted to a neutrophil subset, resulting in CD177(pos)/mPR3(high) and CD177(neg)/mPR3(low) populations. The CD177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f00339148a952681383d4a4301a83b
https://pubmed.ncbi.nlm.nih.gov/35063507
https://pubmed.ncbi.nlm.nih.gov/35063507
CD177 is a neutrophil-specific receptor presenting proteinase 3 (PR3) autoantigen on the neutrophil surface. CD177 expression is restricted to a neutrophil subset resulting in CD177pos/mPR3highand CD177neg/mPR3lowpopulations. The size of the CD177pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f476624d5e49c86a5078db6b417a7228
http://edoc.mdc-berlin.de/20287/1/20287oa.pdf
http://edoc.mdc-berlin.de/20287/1/20287oa.pdf
Autor:
Julia Bontscho, Sebastian Bachmann, Uwe Jerke, Jan Klocke, Adrian Schreiber, Suncica Popovic, Ulf Panzer, Kai M. Schmidt-Ott, Muhammad Imtiaz Ashraf, Volker Siffrin, Anthony Rousselle, Ralph Kettritz
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Neutrophil gelatinase–associated lipocalin (NGAL) is a diagnostic marker of intrinsic kidney injury produced by damaged renal cells and by neutrophils. ANCA-associated vasculitis features necrotizing crescentic GN (NCGN), and ANCA-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04852ef86ccd4a9d5da74940f2b270e
https://europepmc.org/articles/PMC7350985/
https://europepmc.org/articles/PMC7350985/
Autor:
Stefan Kreideweiss, Adrian Schreiber, Peter Eickholz, Katrin Nickles, Anthony Rousselle, Uwe Jerke, Brice Korkmaz, Marc Grundl, Ralph Kettriz, Claudia Eulenberg-Gustavus
Publikováno v:
Rheumatology. 58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2041525dfc8f5304f8e461185d6ad95
https://doi.org/10.1093/rheumatology/kez061.011
https://doi.org/10.1093/rheumatology/kez061.011
Publikováno v:
Journal of Biological Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::8727e925db34e70b9981d398e96c7733
Publikováno v:
Scientific Reports
Proteinase 3 is a serine protease found in neutrophil granules and on the extracellular neutrophil membrane (mPR3). mPR3 is a major antigen for anti-neutrophil cytoplasmic antibodies (PR3-ANCAs), autoantibodies causing fatal autoimmune diseases. In m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159f6f07ce35e5c32cd579ad92ee3659
https://doi.org/10.17169/refubium-23539
https://doi.org/10.17169/refubium-23539