Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Uwe Jacob"'
Autor:
Todd A. Braciak, Claudia C. Roskopf, Sarah Wildenhain, Nadja C. Fenn, Christian B. Schiller, Ingo A. Schubert, Uwe Jacob, Annemarie Honegger, Christina Krupka, Marion Subklewe, Karsten Spiekermann, Karl-Peter Hopfner, Georg H. Fey, Michael Aigner, Stefan Krause, Andreas Mackensen, Fuat S. Oduncu
Publikováno v:
OncoImmunology, Vol 7, Iss 9 (2018)
A number of agents designed for immunotherapy of Acute Myeloid Leukemia (AML) are in preclinical and early clinical development. Most of them target a single antigen on the surface of AML cells. Here we describe the development and key biological pro
Externí odkaz:
https://doaj.org/article/9c33b3300b544ab9bf536064eecde761
Autor:
Ingo Schubert, Christina Krupka, Andreas Mackensen, Karsten Spiekermann, Annemarie Honegger, Sarah Wildenhain, Todd A. Braciak, Stefan W. Krause, Marion Subklewe, Nadja C. Fenn, Uwe Jacob, Christian B. Schiller, Georg H. Fey, Michael Aigner, Claudia C. Roskopf, Fuat Oduncu, Karl-Peter Hopfner
Publikováno v:
OncoImmunology, Vol 7, Iss 9 (2018)
Oncoimmunology
Oncoimmunology
A number of agents designed for immunotherapy of Acute Myeloid Leukemia (AML) are in preclinical and early clinical development. Most of them target a single antigen on the surface of AML cells. Here we describe the development and key biological pro
Autor:
Karl-Peter Hopfner, Alexandra Schele, Ursula J.E. Seidel, Nadja C. Fenn, Annemarie Honegger, Christian B. Schiller, Todd A. Braciak, Sarah Wildenhain, Fuat Oduncu, Ingo Schubert, Kerstin Lämmermann, Peter Lang, Georg H. Fey, Claudia C. Roskopf, Uwe Jacob
Publikováno v:
Oncotarget
// Christian B. Schiller 1, * , Todd A. Braciak 2, * , Nadja C. Fenn 1, * , Ursula J. E. Seidel 3, * , Claudia C. Roskopf 2, * , Sarah Wildenhain 1, * , Annemarie Honegger * , Ingo A. Schubert 5 , Alexandra Schele 1 , Kerstin Lammermann 2 , Georg H.
Autor:
Uwe Jacob, Hannah Pellkofer, Beatrix Schäfer, Robert Huber, Christopher Linington, Constanze Breithaupt
Publikováno v:
The Journal of Immunology. 181:1255-1263
Conformational epitopes of myelin oligodendrocyte glycoprotein (MOG) provide a major target for demyelinating autoantibodies in experimental autoimmune encephalomyelitis and recent studies indicate that a similar situation may exist in multiple scler
Autor:
Peter Sondermann, Reinhold E. Schmidt, Kenji Kamino, Torsten Witte, David Trick, Uwe Jacob, Brigitte Schlegelberger, Andreas Tiede, Katja Kniesch, Sonja Werwitzke
Publikováno v:
Annals of the Rheumatic Diseases. 67:154-161
Objectives: Systemic lupus erythematosus (SLE) is a classical autoimmune disorder characterised by the production of IgG autoantibodies against double-stranded DNA (dsDNA). Activation of FcγR-bearing effector cells by immune complexes (ICs) is a key
Autor:
Gleb Bourenkov, Thomas Steiner, Stephan Krapp, Rita Gerardy-Schahn, Robert Huber, Petra Hess, Uwe Jacob, Anne-Christin Lamerz, Constanze Breithaupt
Publikováno v:
Journal of Biological Chemistry. 282:13003-13010
Uridine diphosphate-glucose pyrophosphorylase (UGPase) represents a ubiquitous enzyme, which catalyzes the formation of UDP-glucose, a key metabolite of the carbohydrate pathways of all organisms. In the protozoan parasite Leishmania major, which cau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:228-234
The urokinase-type plasminogen activator (uPA) is a protein involved in tissue remodeling and other biological processes. The inhibitors of uPA have been shown to prevent the spread of metastasis and tumor growth, and accordingly this enzyme is widel
Autor:
Jens T. Kaiser, Robert Huber, Uwe Jacob, Stephan Krapp, Joe Tiralongo, Anja K. Münster-Kühnel, Rita Gerardy-Schahn
Publikováno v:
Journal of Molecular Biology. 334:625-637
Sialic acids are activated by CMP-5-N-acetylneuraminic acid synthetase prior to their transfer onto oligo- or polysaccharides. Here, we present the crystal structure of the N-terminal catalytically active domain of the murine 5-N-acetylneuraminic aci
Autor:
Uwe Jacob, Günter A. Peschek, Christian Obinger, Paul G. Furtmüller, Robert Huber, Günther Regelsberger, Werner Atzenhofer
Publikováno v:
Journal of Molecular Biology. 321:479-489
Cyanobacteria are shown to be unique in containing membrane-bound manganese superoxide dismutases (MnSOD). They are homodimeric type 2 membrane proteins that protect this phototrophic organism against oxidative stress. We have determined, for the fir
Autor:
Karl-Peter Hopfner, Nadja C. Fenn, Sarah Wildenhain, Christian B. Schiller, Uwe Jacob, Fuat Oduncu, Claudia C. Roskopf, Todd A. Braciak, Georg H. Fey
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts The design of antibody derivatives with higher tumour cell selectivity is hoped to improve cancer immunotherapy and to decrease side effects. One promising molecular format that we have developed is the triple body. A triple body al