Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Uwe J F Tietge"'
Autor:
Jan Freark de Boer, Arne Dikkers, Angelika Jurdzinski, Johann von Felden, Matthias Gaestel, Udo Bavendiek, Uwe J F Tietge
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106300 (2014)
Adipose tissue inflammation is considered an important contributor to insulin resistance. Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is a major downstream target of p38 MAPK and enhances inflammatory processes. In line with the
Externí odkaz:
https://doaj.org/article/a8b7b51b440046a1b66b25481731a83b
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86404 (2014)
Adiponectin (APN), an adipocytokine produced by adipose tissue, exerts pleiotropic actions regulating inflammation, metabolism and vascular homeostasis. APN levels are inversely correlated with obesity, type-2 diabetes, hypertension and cardiovascula
Externí odkaz:
https://doaj.org/article/8f49fcd4e3ab4e70a6ab38acce202197
Autor:
Martine Bot, Paul P Van Veldhoven, Saskia C A de Jager, Jason Johnson, Niels Nijstad, Peter J Van Santbrink, Marijke M Westra, Gerd Van Der Hoeven, Marion J Gijbels, Carsten Müller-Tidow, Georg Varga, Uwe J F Tietge, Johan Kuiper, Theo J C Van Berkel, Jerzy-Roch Nofer, Ilze Bot, Erik A L Biessen
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63360 (2013)
Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(
Externí odkaz:
https://doaj.org/article/1a0d95655b81411ea2e0c24d8f384462
Autor:
Jürgen W. A. Sijbesma, Aren van Waarde, Sebastiaan Kristensen, Ilse Kion, Uwe J. F. Tietge, Jan-Luuk Hillebrands, Marian L. C. Bulthuis, Hendrik Buikema, Dalibor Nakladal, Marit Westerterp, Fan Liu, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Riemer H. J. A. Slart
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background The apolipoprotein E-deficient (apoE −/− ) mouse is a well-established model for studying atherosclerosis. However, its small size limits its use in longitudinal positron emission tomography (PET) imaging studies. Recently, th
Externí odkaz:
https://doaj.org/article/e815cbc78a3e4fae8f600fd68f64930c
Autor:
Christina Grothusen, Harald Schuett, Anja Hillmer, Stefan Lumpe, Karsten Grote, Matthias Ballmaier, Andre Bleich, Silke Glage, Uwe J F Tietge, Maren Luchtefeld, Bernhard Schieffer
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51608 (2012)
While the impact of inflammation as the substantial driving force of atherosclerosis has been investigated in detail throughout the years, the influence of negative regulators of pro-atherogenic pathways on plaque development has remained largely unk
Externí odkaz:
https://doaj.org/article/f6b4cd3620c2498ca2ca9b683125b5d5
Autor:
Maaike H Oosterveer, Theo H van Dijk, Uwe J F Tietge, Theo Boer, Rick Havinga, Frans Stellaard, Albert K Groen, Folkert Kuipers, Dirk-Jan Reijngoud
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e6066 (2009)
BACKGROUND:High-fat diets promote hepatic lipid accumulation. Paradoxically, these diets also induce lipogenic gene expression in rodent liver. Whether high expression of these genes actually results in an increased flux through the de novo lipogenic
Externí odkaz:
https://doaj.org/article/7b4555d7a1d045ce9fb6ab94edc1d9db
Autor:
Nuan Lin, Koen van Zomeren, Teelkien van Veen, Aldona Mzyk, Yue Zhang, Xiaoling Zhou, Torsten Plosch, Uwe J. F. Tietge, Astrid Cantineau, Annemieke Hoek, Romana Schirhagl
Publikováno v:
ACS Central Science, Vol 9, Iss 9, Pp 1784-1798 (2023)
Externí odkaz:
https://doaj.org/article/84c60742671543a9b061ec2454d8b5e3
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 16 (2023)
Externí odkaz:
https://doaj.org/article/1ba3c64df4e3423c9f61a1f55dcba755
Autor:
Johanna E. Emmens, Congzhuo Jia, Leong L. Ng, Dirk J. van Veldhuisen, Kenneth Dickstein, Stefan D. Anker, Chim C. Lang, Gerasimos Filippatos, John G. F. Cleland, Marco Metra, Adriaan A. Voors, Rudolf A. de Boer, Uwe J. F. Tietge
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 9 (2021)
Background We recently showed that, in patients with heart failure, lower high‐density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow‐up study, we suggested that this
Externí odkaz:
https://doaj.org/article/5575ab784f3a4000875dbe6a6d4b97c9
Publikováno v:
Nature Reviews Nephrology.