Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Uwe Eberspaecher"'
Autor:
Niels Böhnke, Markus Berger, Nils Griebenow, Antje Rottmann, Michael Erkelenz, Stefanie Hammer, Sandra Berndt, Judith Günther, Antje M. Wengner, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jörißen, Naomi Barak, Ulf Bömer, Roman C. Hillig, Uwe Eberspaecher, Jörg Weiske, Anja Giese, Dominik Mumberg, Carl Friedrich Nising, Hilmar Weinmann, Anette Sommer
Publikováno v:
Bioconjugate chemistry. 33(6)
Inhibition of intracellular nicotinamide phosphoribosyltransferase (NAMPT) represents a new mode of action for cancer-targeting antibody-drug conjugates (ADCs) with activity also in slowly proliferating cells. To extend the repertoire of available ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382f52dbd2ea6891f52b4f7a2d6e442b
https://pubmed.ncbi.nlm.nih.gov/35658441
https://pubmed.ncbi.nlm.nih.gov/35658441
Autor:
Gerhard Siemeister, Amaury Ernesto Fernandez-Montalvan, Volker K Schulze, Uwe Eberspaecher, Roland Neuhaus, Simon Holton, Stefan Prechtl, Michael Brands, Benjamin Bader, Marian Raschke, Duy Nguyen, Tobias Marquardt, Dirk Kosemund, Detlef Stöckigt, Ulf Bömer, Bertolt Kreft, Hartmut Schirok, Rolf Bohlmann, Antje Margret Wengner, Philip Lienau, Marcus Koppitz, Franz von Nussbaum, Rolf Jautelat, Michael Dr. Brüning, Hans Briem, Dominik Mumberg, Karl Ziegelbauer, Ulrich Klar, Olaf Döhr
Publikováno v:
Journal of Medicinal Chemistry. 63:8025-8042
Inhibition of monopolar spindle 1 (MPS1) kinase represents a novel approach to cancer treatment: instead of arresting the cell cycle in tumor cells, cells are driven into mitosis irrespective of DNA damage and unattached/misattached chromosomes, resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d455cb11862ac96ed455f56494ef1c0a
https://doi.org/10.1021/acs.jmedchem.9b02035
https://doi.org/10.1021/acs.jmedchem.9b02035
Autor:
Timothy A. Lewis, Franziska Siegel, Ulf Boemer, Bethany Kaplan, Heidi Greulich, Franz von Nussbaum, Jens Schroeder, Stephan Siegel, K. Petersen, Ursula Moenning, Mario Hermsen, Florian Prinz, Matthew Meyerson, Sabine Zitzmann-Kolbe, Andrew D. Cherniack, Daniel Korr, Detlev Suelzle, Uwe Eberspaecher, Knut Eis, Keith Graham, Gizem Karsli-Uzunbas
Publikováno v:
Cancer Research. 81:1470-1470
Several targeted therapeutic options exist for non-small cell lung cancer (NSCLC) patients whose tumors harbor mutations of EGFR, including L858R, exon 19 deletions, and the acquired resistance mutation, T790M. However, there is no approved targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6267af0034fe42b36e3b59f0f149a452
https://doi.org/10.1158/1538-7445.am2021-1470
https://doi.org/10.1158/1538-7445.am2021-1470
Autor:
Uwe Eberspaecher, Rienk Offringa, Gabriele Leder, Judith Guenther, Roland Neuhaus, Bertolt Kreft, Rafael Carretero, Jeffrey Mowat, Ingo Hartung, Ulf Boemer, Martina Schaefer, Nicolas Werbeck, Mine Oezcan-Wahlbrink, Nuria Aiguabella Font, Sandra Berndt, Barbara Nicke, Corinna Link, Oliver von Ahsen, Mareike Grees, Daniel Baumann
Publikováno v:
Cancer Research. 81:1722-1722
Immune checkpoint blockade using antibodies targeting the cell surface expressed proteins CTLA-4, PD-1 and PD-L1 has revolutionized cancer care and its clinical impact in several indications has prompted a search for complementary immunostimulatory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c95b8a195d1c33ac1081db66cf562fd
https://doi.org/10.1158/1538-7445.am2021-1722
https://doi.org/10.1158/1538-7445.am2021-1722
Autor:
Franziska Siegel, Carl Friedrich Nising, Franz von Nussbaum, Ulf Boemer, Herbert Himmel, Detlev Suelzle, Marcus Bauser, Uwe Eberspaecher, Simon Holton, Joerg Weiske, Florian Prinz, Ralf Lesche, Clara Lemos, Dominik Mumberg, Dieter Moosmayer, Knut Eis, Andrea Haegebarth, Stefan Prechtl, Barbara Nicke, Duy Nguyen, Lars Wortmann, Christian Lechner, Katrin Nowak-Reppel
Publikováno v:
Journal of medicinal chemistry. 62(2)
The availability of a chemical probe to study the role of a specific domain of a protein in a concentration- and time-dependent manner is of high value. Herein, we report the identification of a highly potent and selective ERK5 inhibitor BAY-885 by h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4f7f3e30ce07bd6a816fc7f0903438
https://pubmed.ncbi.nlm.nih.gov/30563338
https://pubmed.ncbi.nlm.nih.gov/30563338
Autor:
Andrea Haegebarth, Stephan Siegel, Bernard Haendler, Uwe Eberspaecher, Antonius Ter Laak, Nicolas Werbeck, Ralf Lesche, Carlo Stresemann, Amaury Ernesto Fernandez-Montalvan, Ursula Moenning, Krzysztof Brzezinka, Ashley Eheim, Ekaterina Nevedomskaya
Publikováno v:
Cancers
Volume 12
Issue 1
Cancers, Vol 12, Iss 1, p 201 (2020)
Volume 12
Issue 1
Cancers, Vol 12, Iss 1, p 201 (2020)
Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has recently emerged as a novel therapeutic strategy. Beneficial therapeutic effects have been postulated in leukemia, prostate, breast, liver and in synovial sarcoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce205e6a5f2790b5798ac6e5d82c879
https://doi.org/10.3390/cancers12010201
https://doi.org/10.3390/cancers12010201
Autor:
S. Miranda, Peter Donner, M. A. A. Thomaz, Roman Hillig, Vera Pütter, Caterina Holz, Jörg Fanghänel, Uwe Eberspaecher, Maria Arménia Carrondo, Pedro M. Matias, Patrick Amstutz, Christine Lang, Kerstin Crusius, Maya Gulotti-Georgieva, Beate Muller-Tiemann, H. Kaspar Binz, Ursula Egner, Tiago M. Bandeiras, Arndt Schmitz
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 64:339-353
As a key regulator of mitosis, the Ser/Thr protein polo-like kinase-1 (Plk-1) is a well validated drug target in cancer therapy. In order to enable structure-guided drug design, determination of the crystal structure of the kinase domain of Plk-1 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f8b5b6e2a5898f1e802d4480ee6e5b
https://doi.org/10.1107/s0907444907068217
https://doi.org/10.1107/s0907444907068217
Autor:
Carolyn Sperl, Sylvia Gruenewald, Uwe Eberspaecher, Patrick Steigemann, Wolfgang Schwede, Roland Neuhaus, Ludwig Zorn, Sylvia Zacharias, Kai Thede, Alexander Walter, Sven Christian
Publikováno v:
Cancer Research. 77:4989-4989
With three-dimensional growth conditions, multicellular tumor spheroids reproduce several parameters of the tumor microenvironment, including oxygen and nutrient gradients, characteristic of poorly vascularized tumor regions. 3D high content screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b6c35cf1bff7e1ee1102293d7c42651
https://doi.org/10.1158/1538-7445.am2017-4989
https://doi.org/10.1158/1538-7445.am2017-4989
Publikováno v:
Cell and Tissue Research. 303:277-287
The zona pellucida of mammalian oocytes plays an important role in binding and activation of sperm cells during the molecular events leading to fertilization. The genes coding for the three zona pellucida glycoproteins ZPA, ZPB, and ZPC of various sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216ff45584160ace5dae58439120be32
https://doi.org/10.1007/s004410000287
https://doi.org/10.1007/s004410000287
Autor:
Jörn Krätzschmar, Peter Donner, Bernard Haendler, Dirk Roosterman, Uwe Eberspaecher, Wolf-Dieter Schleuning
Publikováno v:
European Journal of Biochemistry. 236:827-836
We report the isolation and characterisation of cDNAs encoding three different, human members of the cysteine-rich secretory protein (CRISP) family. The novel CRISP-1 exists in five cDNA subtypes differing by the presence or absence of a stretch codi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0357b702d0153652400b78815259ab
https://doi.org/10.1111/j.1432-1033.1996.t01-1-00827.x
https://doi.org/10.1111/j.1432-1033.1996.t01-1-00827.x