Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Uwe Andag"'
Autor:
Amy J. Osborne, Agnieszka Bierzynska, Elizabeth Colby, Uwe Andag, Philip A. Kalra, Olivier Radresa, Philipp Skroblin, Maarten W. Taal, Gavin I. Welsh, Moin A. Saleem, Colin Campbell
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Chronic kidney diseases (CKD) have genetic associations with kidney function. Univariate genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with estimated glomerular filtration rate (eGFR
Externí odkaz:
https://doaj.org/article/720dcb90cc644525b4ddd6be5815d98b
Autor:
Jürgen Stumm, Antje Schmidt, Wiebke Gehrmann, Maren Feist, Rüdiger Fritsch, Karsten Kottig, Franz Dürrenberger, Joel Krauser, Carol Moreno Quinn, Olivier Radresa, Christian Stegmann, Uwe Andag
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS As part of the renal filtration barrier, podocytes are critical to the function of kidney glomeruli. Their loss is one of the hallmarks of chronic kidney disease, including diabetic kidney disease (DKD). Indeed, many drug discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26e458e8dfc6902386515be96a1ac4f2
https://doi.org/10.1093/ndt/gfac097.001
https://doi.org/10.1093/ndt/gfac097.001
Autor:
Tobias Bohnenpoll, Eric Olson, Mykola Dergai, Jennifer Cox, Simone Romoli, I-Ju Lo, Johannes Pospiech, Krishan Vishnolia, Mark Mcconnell, Marvin Gunawan, Michaela Bayerlová, Nicolette Honson, Niklas Michel, Nikolas Stroth, Olivier Radresa, Philipp Skroblin, Priyanka Kohli, Seamus Ragan, Shenshen Lai, Steven Bromidge, David Powell, Uwe Andag, Andrew King
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND Conventional stratification by clinical and histopathological phenotypes only approximates the heterogeneity of chronic kidney disease (CKD) and is insufficient to drive discovery of disease-modifying therapies or predict clinical outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9229435806dc92096d71084c602a577f
https://doi.org/10.1093/ndt/gfac114.004
https://doi.org/10.1093/ndt/gfac114.004
Autor:
Nils Burkhardt, Stefan Golz, Hauke Cornils, Uwe Andag, Robert J Turner, Ina Sternberger, Carina Wollnik
Publikováno v:
Slas Discovery
Kidney fibrosis presents a hallmark of chronic kidney disease. With ever-increasing patient numbers and limited treatment options available, novel strategies for therapeutic intervention in kidney disease are warranted. Fibrosis commonly results from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895b0d58f46e83300bbf74871df79cbf
https://doi.org/10.1177/2472555220915851
https://doi.org/10.1177/2472555220915851
Autor:
Michael Feigh, Joseph Grimsby, Pernille Barkholt, Matthias Austen, John Le Lay, Terrence O'Day, Lutz Jermutus, Chester Bittencourt Sacramento, David M. Smith, Christina Reers, Stephanie Oldham, Maria Sörhede Winzell, James L. Trevaskis, Christopher J. Rhodes, Victor G. Howard, Brandon B. Boland, Jennifer Cann, Nicholas Bhagroo, Cord Dohrmann, Yuan Chang, Safina Ali, Cristina M. Rondinone, Uwe Andag, Kay Schreiter, Arun Sharma, Hani A. Jouihan, Matthew P. Coghlan, Simon Thompson
Publikováno v:
Diabetes. 66(7)
Neurturin (NRTN), a member of the glial-derived neurotrophic factor family, was identified from an embryonic chicken pancreatic cDNA library in a screen for secreted factors. In this study, we assessed the potential antidiabetic activities of NRTN re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22df68faf7c73de1a63baaf903cf58d6
https://pubmed.ncbi.nlm.nih.gov/28408435
https://pubmed.ncbi.nlm.nih.gov/28408435
Autor:
Hans Dieter Schmitt, Uwe Andag
Publikováno v:
Journal of Biological Chemistry
Dsl1p is required for Golgi-endoplasmic reticulum (ER) retrograde transport in yeast. It interacts with the ER resident protein Tip20p and with delta-COP, a subunit of coatomer, the coat complex of COPI vesicles. To test the significance of these int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a533fe6f4ac7a8b12026c57544e5a84b
https://doi.org/10.1074/jbc.m308740200
https://doi.org/10.1074/jbc.m308740200
Autor:
Wolf-Georg Forssmann, Harald John, Thomas Braulke, Ludger Ständker, Claudia Draeger, Bernd Kübler, Jens-Gerd Scharf, Uwe Andag
Publikováno v:
FEBS Letters. 518:124-128
Proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3), the major carrier of IGFs in the circulation, is an essential mechanism to regulate IGF bioavailability. To analyze naturally occurring IGFBP-3 fragments a peptide library establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936b4c84b022b46fdd2c652b41352ba8
https://doi.org/10.1016/s0014-5793(02)02673-x
https://doi.org/10.1016/s0014-5793(02)02673-x
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology
In eukaryotic cells, secretion is achieved by vesicular transport. Fusion of such vesicles with the correct target compartment relies on SNARE proteins on both vesicle (v-SNARE) and the target membranes (t-SNARE). At present it is not clear how v-SNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abddf257f28aedee2d843fcecbb96b4
http://europepmc.org/articles/PMC2173288
http://europepmc.org/articles/PMC2173288
Publikováno v:
Journal of Biological Chemistry. 276:39150-39160
Sec22p is an endoplasmic reticulum (ER)-Golgi v-SNARE protein whose retrieval from the Golgi compartment to the endoplasmic reticulum (ER) is mediated by COPI vesicles. Whether Sec22p exhibits its primary role at the ER or the Golgi apparatus is stil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7241f3014f27c0848ad0d5d66e1f3e1a
https://doi.org/10.1074/jbc.m105833200
https://doi.org/10.1074/jbc.m105833200
Autor:
Matthias Austen, Simone Kegel, Alexander Lomow, Marcus Geese, Ulrike Burk, Daria Onichtchouk, Cord Dohrmann, Friedrich Harder, Uwe Andag, Rainer Mussmann
Publikováno v:
The Journal of biological chemistry. 282(16)
Recent developments indicate that the regeneration of beta cell function and mass in patients with diabetes is possible. A regenerative approach may represent an alternative treatment option relative to current diabetes therapies that fail to provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808627b0b521c6951580253f610cb414
https://pubmed.ncbi.nlm.nih.gov/17242403
https://pubmed.ncbi.nlm.nih.gov/17242403