Zobrazeno 1 - 10
of 724
pro vyhledávání: '"Uwe, Völker"'
Autor:
Fabian Frost, Stefan Weiss, Johannes Hertel, Malte Rühlemann, Corinna Bang, Andre Franke, Matthias Nauck, Marcus Dörr, Henry Völzke, Dirk Roggenbuck, Peter Schierack, Uwe Völker, Georg Homuth, Ali A. Aghdassi, Matthias Sendler, Markus M. Lerch, Frank U. Weiss
Publikováno v:
Gut Pathogens, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Antimicrobial autoantigenic glycoprotein 2 (GP2) is an important component of the innate immune system which originates from the exocrine pancreas as well as from the small intestines. The relationship of GP2 with the intestinal m
Externí odkaz:
https://doaj.org/article/c58f07de2a2f40068a82097d56140e30
Autor:
Anna Halama, Shaza Zaghlool, Gaurav Thareja, Sara Kader, Wadha Al Muftah, Marjonneke Mook-Kanamori, Hina Sarwath, Yasmin Ali Mohamoud, Nisha Stephan, Sabine Ameling, Maja Pucic Baković, Jan Krumsiek, Cornelia Prehn, Jerzy Adamski, Jochen M. Schwenk, Nele Friedrich, Uwe Völker, Manfred Wuhrer, Gordan Lauc, S. Hani Najafi-Shoushtari, Joel A. Malek, Johannes Graumann, Dennis Mook-Kanamori, Frank Schmidt, Karsten Suhre
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract In-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and sa
Externí odkaz:
https://doaj.org/article/711d016111244d3c97a32572e4aba254
Autor:
Alissa Brauneck, Louisa Schmalhorst, Stefan Weiss, Linda Baumbach, Uwe Völker, David Ellinghaus, Jan Baumbach, Gabriele Buchholtz
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Genomic data holds huge potential for medical progress but requires strict safety measures due to its sensitive nature to comply with data protection laws. This conflict is especially pronounced in genome-wide association studies (GWAS) whic
Externí odkaz:
https://doaj.org/article/02cc3e4eaf884272bb38bfbc66c04ad2
Autor:
Mohamed A. Elhadad, Mónica del C. Gómez-Alonso, Chien-Wei Chen, Sonja Neumeyer, Thomas Delerue, Wolfgang Rathmann, Michael Näbauer, Christa Meisinger, Stefan Kääb, Jochen Seissler, Johannes Graumann, Wolfgang Koenig, Karsten Suhre, Christian Gieger, Uwe Völker, Annette Peters, Elke Hammer, Melanie Waldenberger
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background and aims Atherosclerosis is the main cause of stroke and coronary heart disease (CHD), both leading mortality causes worldwide. Proteomics, as a high-throughput method, could provide helpful insights into the pathological mechanis
Externí odkaz:
https://doaj.org/article/27d62746d13f4cb9b09770b2fb66f876
Autor:
William J. Young, Peter J. van der Most, Traci M. Bartz, Maxime M. Bos, Ginevra Biino, ThuyVy Duong, Luisa Foco, Jesus T. Lominchar, Martina Müller‐Nurasyid, Giuseppe Giovanni Nardone, Alessandro Pecori, Julia Ramirez, Linda Repetto, Katharina Schramm, Xia Shen, Stefan van Duijvenboden, Diana van Heemst, Stefan Weiss, Jie Yao, Jan‐Walter Benjamins, Alvaro Alonso, Beatrice Spedicati, Mary L. Biggs, Jennifer A. Brody, Marcus Dörr, Christian Fuchsberger, Martin Gögele, Xiuqing Guo, M. Arfan Ikram, J. Wouter Jukema, Stefan Kääb, Jørgen K. Kanters, Henry J. Lin, Allan Linneberg, Matthias Nauck, Ilja M. Nolte, Giulia Pianigiani, Aurora Santin, Elsayed Z. Soliman, Paola Tesolin, Simona Vaccargiu, Melanie Waldenberger, Pim van der Harst, Niek Verweij, Dan E. Arking, Maria Pina Concas, Alessandro De Grandi, Giorgia Girotto, Niels Grarup, Maryam Kavousi, Dennis O. Mook‐Kanamori, Pau Navarro, Michele Orini, Sandosh Padmanabhan, Cristian Pattaro, Annette Peters, Mario Pirastu, Peter P. Pramstaller, Susan R. Heckbert, Mortiz Sinner, Harold Snieder, Uwe Völker, James F. Wilson, W. James Gauderman, Pier D. Lambiase, Nona Sotoodehnia, Andrew Tinker, Helen R. Warren, Raymond Noordam, Patricia B. Munroe
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background Ventricular repolarization time (ECG QT and JT intervals) is associated with malignant arrhythmia. Genome‐wide association studies have identified 230 independent loci for QT and JT; however, 50% of their heritability remains unexplained
Externí odkaz:
https://doaj.org/article/d9db835045cc4f1b993097b3854693a3
Zyxin is important for the stability and function of podocytes, especially during mechanical stretch
Autor:
Felix Kliewe, Florian Siegerist, Elke Hammer, Jaafar Al-Hasani, Theodor Rolf Jakob Amling, Jonas Zeno Eddy Hollemann, Maximilian Schindler, Vedran Drenic, Stefan Simm, Kerstin Amann, Christoph Daniel, Maja Lindenmeyer, Markus Hecker, Uwe Völker, Nicole Endlich
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for podocyte stability and function. We have found that zyxin is significantly up-regulated in pod
Externí odkaz:
https://doaj.org/article/aeac6a2a22ce4682a2efff53ba47a07d
Autor:
Lea A. Tölken, Antje D. Paulikat, Lana H. Jachmann, Alexander Reder, Manuela Gesell Salazar, Laura M. Palma Medina, Stephan Michalik, Uwe Völker, Mattias Svensson, Anna Norrby-Teglund, Katharina J. Hoff, Michael Lammers, Nikolai Siemens
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-17 (2024)
Abstract Background Streptococcus pyogenes (group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections of the throat and skin to severe invasive infections, such as necrotizing soft tissue infections (NSTIs). Ti
Externí odkaz:
https://doaj.org/article/8cfa48c1af2241b6be605e7677b877f0
Autor:
Alexander Ganske, Larissa Milena Busch, Christian Hentschker, Alexander Reder, Stephan Michalik, Kristin Surmann, Uwe Völker, Ulrike Mäder
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Staphylococcus aureus is a common colonizer of the skin and nares of healthy individuals, but also a major cause of severe human infections. During interaction with the host, pathogenic bacteria must adapt to a variety of adverse conditions including
Externí odkaz:
https://doaj.org/article/c3628aeca859461c9047f82a7801386d
Autor:
Martín Alcorlo, Mohammed R Abdullah, Leif Steil, Francisco Sotomayor, Laura López-de Oro, Sonia de Castro, Sonsoles Velázquez, Thomas P Kohler, Elisabet Jiménez, Ana Medina, Isabel Usón, Lance E Keller, Jessica L Bradshaw, Larry S McDaniel, María-José Camarasa, Uwe Völker, Sven Hammerschmidt, Juan A Hermoso
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1011883 (2024)
ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the energy balance. The cell surface of the pathobiont Streptococcus pneumoniae (pneumococcus) is
Externí odkaz:
https://doaj.org/article/b962a379033346788836c4582103dd80
Autor:
Goran Abdurrahman, Rebecca Pospich, Leif Steil, Manuela Gesell Salazar, Juan José Izquierdo González, Nicole Normann, Daniel Mrochen, Christian Scharf, Uwe Völker, Thomas Werfel, Barbara M. Bröker, Lennart M. Roesner, Lidia Gómez-Gascón
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAtopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with skin barrier defects and a misdirected type 2 immune response against harmless antigens. The skin microbiome in AD is characterized by a reduction in microbial di
Externí odkaz:
https://doaj.org/article/2ffbfd599c934f85a83ca84c7246d9c5