Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Uwe, Thiel"'
Autor:
Hendrik Gassmann, Melanie Thiede, Jennifer Weiß, Emilie Biele, Luisa Flohé, Helena Lachermaier, Carolin Prexler, Valentina Evdokimova, Laszlo Radvanyi, Irfan Akhtar, Mina N. F. Morcos, Franziska Auer, Sebastian J. Schober, Julia Hauer, Uwe Thiel, Kristina von Heyking
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPediatric sarcomas, including osteosarcoma (OS), Ewing sarcoma (EwS) and rhabdomyosarcoma (RMS) carry low somatic mutational burden and low MHC-I expression, posing a challenge for T cell therapies. Our previous study showed that mediator
Externí odkaz:
https://doaj.org/article/3d9ee74067034b06a597ba56f56322a7
Autor:
Anna Josefine von Ofen, Uwe Thiel, Jennifer Eck, Hendrik Gassmann, Melanie Thiede, Julia Hauer, Per Sonne Holm, Sebastian J. Schober
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Oncolytic viruses (OVs) selectively replicate in tumor cells resulting in lysis, spreading of new infectious units and induction of antitumor immune responses through abrogating an immunosuppressive tumor microenvironment (TME). Due to their mode of
Externí odkaz:
https://doaj.org/article/b4b04f635fa041b693d1f5af12a9aa32
Autor:
Sebastian J. Schober, Melanie Thiede, Hendrik Gassmann, Anna Josefine von Ofen, Pia Knoch, Jennifer Eck, Carolin Prexler, Corazon Kordass-Wally, Julia Hauer, Stefan Burdach, Per Sonne Holm, Uwe Thiel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundEwing sarcoma (EwS) is an aggressive and highly metastatic bone and soft tissue tumor in pediatric patients and young adults. Cure rates are low when patients present with metastatic or relapsed disease. Therefore, innovative therapy approa
Externí odkaz:
https://doaj.org/article/a52e819a36954a5cb6c30fb713880fa2
Autor:
Florencia Cidre-Aranaz, Jing Li, Tilman L. B. Hölting, Martin F. Orth, Roland Imle, Stefanie Kutschmann, Giulia Ammirati, Katharina Ceranski, Martha Julia Carreño-Gonzalez, Merve Kasan, Aruna Marchetto, Cornelius M. Funk, Felix Bestvater, Simone Bersini, Chiara Arrigoni, Matteo Moretti, Uwe Thiel, Daniel Baumhoer, Felix Sahm, Stefan M. Pfister, Wolfgang Hartmann, Uta Dirksen, Laura Romero-Pérez, Ana Banito, Shunya Ohmura, Julian Musa, Thomas Kirchner, Maximilian M. L. Knott, Thomas G. P. Grünewald
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-7 (2022)
Externí odkaz:
https://doaj.org/article/1cce4678ba46427fbe83c1b716396bda
Autor:
Sebastian Johannes Schober, Erika Hallmen, Florian Reßle, Hendrik Gassmann, Carolin Prexler, Angela Wawer, Irene von Luettichau, Ruth Ladenstein, Bernarda Kazanowska, Gustaf Ljungman, Felix Niggli, Olli Lohi, Julia Hauer, Bernd Gruhn, Thomas Klingebiel, Peter Bader, Stefan Burdach, Peter Lang, Monika Sparber-Sauer, Ewa Koscielniak, Uwe Thiel
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundPatients with stage IV alveolar rhabdomyosarcoma (RMA) have a 5-year-survival rate not exceeding 30%. Here, we assess the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for these patients in comparison to standard-of
Externí odkaz:
https://doaj.org/article/a5119f59a6ba4dc19070532c26ea5dc3
Autor:
Sebastian Johannes Schober, Caroline Schoening, Jennifer Eck, Charlotte Middendorf, Julia Lutsch, Pia Knoch, Anna Josefine von Ofen, Hendrik Gassmann, Melanie Thiede, Julia Hauer, Andreas Kolk, Klaus Mantwill, Jürgen E. Gschwend, Stefan E.G. Burdach, Roman Nawroth, Uwe Thiel, Per Sonne Holm
Publikováno v:
Clinical Cancer Research. 29:1996-2011
Purpose: Ewing sarcoma (EwS) is a highly malignant pediatric tumor characterized by a non-T-cell-inflamed immune-evasive phenotype. When relapsed or metastasized, survival is poor, emphasizing the need for novel treatment strategies. Here, we analyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f08cb16f1b3cbe88ceb34bd7c71a636d
https://doi.org/10.1158/1078-0432.ccr-22-1961
https://doi.org/10.1158/1078-0432.ccr-22-1961
Autor:
Emilie Biele, Sebastian J. Schober, Carolin Prexler, Melanie Thiede, Kristina von Heyking, Hendrik Gassmann, Jennifer Eck, Busheng Xue, Stefan Burdach, Uwe Thiel
Publikováno v:
Cells, Vol 10, Iss 11, p 3070 (2021)
Ewing’s sarcoma (EwS) is a pediatric solid tumor entity with low somatic mutational burden and a low rate of tumor-infiltrating T cells, indicating a low extent of immunogenicity. In EwS, immunogenicity may furthermore be significantly diminished b
Externí odkaz:
https://doaj.org/article/a017ee78320743c3be409bf39ee9343b
Autor:
Hendrik Gassmann, Kira Schneider, Valentina Evdokimova, Peter Ruzanov, Sebastian J. Schober, Busheng Xue, Kristina von Heyking, Melanie Thiede, Guenther H. S. Richter, Michael W. Pfaffl, Elfriede Noessner, Lincoln D. Stein, Poul H. Sorensen, Stefan E. G. Burdach, Uwe Thiel
Publikováno v:
Cells, Vol 10, Iss 8, p 2081 (2021)
Ewing sarcoma (EwS) is an aggressive pediatric cancer of bone and soft tissues characterized by scant T cell infiltration and predominance of immunosuppressive myeloid cells. Given the important roles of extracellular vesicles (EVs) in cancer-host cr
Externí odkaz:
https://doaj.org/article/c1356498953842378fc022432faf6255
Autor:
Per Sonne Holm, Uwe Thiel, Roman Nawroth, Stefan E.G. Burdach, Jürgen E. Gschwend, Klaus Mantwill, Andreas Kolk, Julia Hauer, Melanie Thiede, Hendrik Gassmann, Anna Josefine von Ofen, Pia Knoch, Julia Lutsch, Charlotte Middendorf, Jennifer Eck, Caroline Schoening, Sebastian Johannes Schober
Purpose:Ewing sarcoma (EwS) is a highly malignant pediatric tumor characterized by a non-T-cell-inflamed immune-evasive phenotype. When relapsed or metastasized, survival is poor, emphasizing the need for novel treatment strategies. Here, we analyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7436ec5ad0c442db9eb9dc93832cef20
https://doi.org/10.1158/1078-0432.c.6516382
https://doi.org/10.1158/1078-0432.c.6516382
Autor:
Per Sonne Holm, Uwe Thiel, Roman Nawroth, Stefan E.G. Burdach, Jürgen E. Gschwend, Klaus Mantwill, Andreas Kolk, Julia Hauer, Melanie Thiede, Hendrik Gassmann, Anna Josefine von Ofen, Pia Knoch, Julia Lutsch, Charlotte Middendorf, Jennifer Eck, Caroline Schoening, Sebastian Johannes Schober
Supplemental Figure 5: Combination therapy of XVir-N-31 and CDK4/6 inhibitor LEE011 induces calreticulin (CALR) surface expression and increases phagocytosis in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c30b3a1b6f7542170fd4b4f64f32a8d
https://doi.org/10.1158/1078-0432.22820234.v1
https://doi.org/10.1158/1078-0432.22820234.v1