Výsledky vyhledávání - "Uwe, Pschorn"

Local Anaesthetic Properties of Ambroxol Hydrochloride Lozenges in View of Sore Throat

Autor: Uwe Pschorn, Christian de Mey, Achim Müller, Hans-Jürgen Gund, Bernhard Aicher, Adrian Gillissen, Alexander Schutz, Hubertus Peil

Publikováno v: Arzneimittelforschung. 52:194-199

Acute oro-pharyngeal catarrh is characterised by mild to severe sore throat, such as pain on swallowing, feeling of scratchiness, burning and urge to cough. The present study was conducted to explore whether the test compound is going to show clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e281945b98fcceaf2bc07ec6816268d8
https://doi.org/10.1055/s-0031-1299879

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Efficacy and Tolerability of Ambroxol Hydrochloride Lozenges in Sore Throat

Autor: Jean-Michel Vix, Bernhard Aicher, Hubertus Peil, Christian de Mey, Achim Müller, Jürgen Fischer, Uwe Pschorn

Publikováno v: Arzneimittelforschung. 52:256-263

Two confirmatory clinical trials were performed to investigate the efficacy and tolerability of ambroxol lozenges at doses of 20 mg and 30 mg relative to placebo in relieving the symptoms of sore throat of at least moderately severe intensity in pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe43ac507347002388e6877905ce1481
https://doi.org/10.1055/s-0031-1299889

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MRI and MRS studies on the time course of rat brain lesions and the effect of drug treatment: Volume quantification and characterization of tissue heterogeneity by parameter selection

Autor: Hermann Körperich, Winfried Kuhn, Uwe Pschorn, Sankaran Subramanian, Lothar Heymans

Publikováno v: Magnetic Resonance in Medicine. 30:174-182

Magnetic resonance imaging has been used to follow the time course of lesions induced in the rat brain as an animal model for characterization of the volume of the lesion. The dispersion in spin-spin relaxation has been used to characterize the natur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2775d76165b4e5bdd31a82b8790c41d6
https://doi.org/10.1002/mrm.1910300205

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Efficacy and tolerability of ambroxol hydrochloride lozenges in sore throat. Randomised, double-blind, placebo-controlled trials regarding the local anaesthetic properties

Autor: Jürgen, Fischer, Uwe, Pschorn, Jean-Michel, Vix, Hubertus, Peil, Bernhard, Aicher, Achim, Müller, Christian, de Mey

Publikováno v: Arzneimittel-Forschung. 52(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4423e5df82114910fed68bb879336ab2
https://pubmed.ncbi.nlm.nih.gov/12040968

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Local anaesthetic properties of ambroxol hydrochloride lozenges in view of sore throat. Clinical proof of concept

Autor: Alexander, Schutz, Hans-Jürgen, Gund, Uwe, Pschorn, Bernhard, Aicher, Hubertus, Peil, Achim, Müller, Christian, de Mey, Adrian, Gillissen

Publikováno v: Arzneimittel-Forschung. 52(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a0d73693e1f49a8953c2421028dfcea
https://pubmed.ncbi.nlm.nih.gov/11963647

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Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat

Autor: Michael R. Meiler, Kentaro Takano, Christopher H. Sotak, Richard A. D. Carano, Turgut Tatlisumak, Uwe Pschorn, Fuhai Li, Dietrich Arndts, Marc Fisher

Publikováno v: Journal of the neurological sciences. 178(2)

Cation channels conduct calcium, sodium, and potassium, cations that are likely deleterious in the evolution of focal ischemic injury. Diffusion-weighted magnetic resonance imaging (DWI) is a powerful tool for evaluation of acute cerebral ischemia. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1b88fd221f4b9a3687dbec81acfa36
https://pubmed.ncbi.nlm.nih.gov/11018702

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Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL

Autor: Wolf Dietrich Dr Bechtel, Thomas Weiser, Uwe Pschorn, Todd Scheuer, Christina Bartmann-Lindholm, William A. Catterall, Matthias Grauert, Yusheng Qu, Adrian Carter

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 97(9)

We have synthesized a new benzomorphan derivative, 2 R- [2α,3( S *),6α]-1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-3-[2-(phenylmethoxy)propyl]-2,6-methano-3-benzazocin-10-ol hydrochloride (BIII 890 CL), which displaced [ 3 H]batrachotoxinin A-20α-ben

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f917fab263ee97fb6d8f2e2f81d497ac
https://pubmed.ncbi.nlm.nih.gov/10781102

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Broad-Spectrum Cation Channel Inhibition by LOE 908 MS Reduces Infarct Volume in Vivo and Postmortem in Focal Cerebral Ischemia in the Rat

Autor: Christopher H. Sotak, Marc Fisher, Kentaro Takano, Michael R. Meiler, Turgut Tatlisumak, F. Li, Richard A. D. Carano, Uwe Pschorn

Publikováno v: Brain Edema XI ISBN: 9783709172575

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8a9e6425a29f0eb6d500de404dfad95
https://doi.org/10.1007/978-3-7091-6346-7_67

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The influence of repeated doses, route and time of administration on the neuroprotective effects of BIII 277 CL in a rat model of focal cerebral ischemia

Autor: Adrian Carter, Uwe Pschorn

Publikováno v: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 6(2)

Objective . We investigated the influence of dose, route and time of administration on the neuroprotective effects of the noncompetitive N -methyl-D-aspartic acid antagonist BIII 277 CL ([2R-[2α, 3(R*), 6α]]-1,2,3,4,5,6-hexahydro-3-(2-methoxy-propy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a4520d78d88fa205fb9d658e5a089f
https://pubmed.ncbi.nlm.nih.gov/17894976

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[Untitled]

Autor: Bernd Hisgen, Helmut Ringsdorf, Uwe Pschorn, Hans Wolfgang Spiess

Publikováno v: Die Makromolekulare Chemie. 187:2711-2723

The molecular order and mobility of two liquid-crystalline polyacrylates with phenyl benzoate moieties as mesogenic side groups and (CH2)m spacers (m = 2 and m = 6) were investigated by pulsed 2H NMR. The mesogenic side groups were isotopically label

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaf906d4931bd447ca6eb8dca6e19905
https://doi.org/10.1002/macp.1986.021871121

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