Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Uwe, Marx"'
Autor:
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, Erik Müllers, Fredrik Karlsson, Maryam Clausen, Sara F. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Löfmark, Carina Ämmälä, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilén
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-23 (2024)
Abstract Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of key metabolic organs, the pancreas and liv
Externí odkaz:
https://doaj.org/article/6ef35220f5cb430495895d01dab6b095
Autor:
Thi-Phuong Tao, Ilka Maschmeyer, Edward L. LeCluyse, Eda Rogers, Katrin Brandmair, Silke Gerlach, Julia Przibilla, Fredy Kern, Camille Genies, Carine Jacques, Abdulkarim Najjar, Andreas Schepky, Uwe Marx, Jochen Kühnl, Nicola J. Hewitt
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
All cosmetic ingredients registered in Europe must be evaluated for their safety using non-animal methods. Microphysiological systems (MPS) offer a more complex higher tier model to evaluate chemicals. Having established a skin and liver HUMIMIC Chip
Externí odkaz:
https://doaj.org/article/5068186205ee485da21ca6a4409cc5d3
Autor:
Belén Casas, Liisa Vilén, Sophie Bauer, Kajsa P Kanebratt, Charlotte Wennberg Huldt, Lisa Magnusson, Uwe Marx, Tommy B Andersson, Peter Gennemark, Gunnar Cedersund
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010587 (2022)
Microphysiological systems (MPS) are powerful tools for emulating human physiology and replicating disease progression in vitro. MPS could be better predictors of human outcome than current animal models, but mechanistic interpretation and in vivo ex
Externí odkaz:
https://doaj.org/article/4a3bbcd9a4d74df2beadb1ea5c7164c8
Autor:
Uwe Marx, Enrico Accastelli, Rhiannon David, Hendrik Erfurth, Leopold Koenig, Roland Lauster, Anja Patricia Ramme, Petra Reinke, Hans-Dieter Volk, Annika Winter, Eva-Maria Dehne
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
The first concepts for reproducing human systemic organismal biology in vitro were developed over 12 years ago. Such concepts, then called human- or body-on-a-chip, claimed that microphysiological systems would become the relevant technology platform
Externí odkaz:
https://doaj.org/article/749322213ef54553894134ac5bc2c221
Publikováno v:
Data in Brief, Vol 37, Iss , Pp 107140- (2021)
Integration-free induced pluripotent stem cells from related human donors’ exhibit great potential to the ongoing development of organ models. Blood cells from two different human donors were isolated, purified and reprogrammed into induced pluripo
Externí odkaz:
https://doaj.org/article/30606b5951f0441d8513fd0d37b7cfe8
Autor:
Leopold Koenig, Anja Patricia Ramme, Daniel Faust, Manuela Mayer, Tobias Flötke, Anna Gerhartl, Andreas Brachner, Winfried Neuhaus, Antje Appelt-Menzel, Marco Metzger, Uwe Marx, Eva-Maria Dehne
Publikováno v:
Cells, Vol 11, Iss 20, p 3295 (2022)
Significant advancements in the field of preclinical in vitro blood-brain barrier (BBB) models have been achieved in recent years, by developing monolayer-based culture systems towards complex multi-cellular assays. The coupling of those models with
Externí odkaz:
https://doaj.org/article/d684b971a00e49d182de9266e5f64ecb
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102327- (2021)
The integration-free iPSC lines TISSUi006-A and TISSUi007-A were generated by reprogramming blood cells with episomal vectors. The male human donors belong to a Caucasian family in which four additional family members donated and iPSC lines were gene
Externí odkaz:
https://doaj.org/article/3f0d57c6b0854d63982cdc9229c23e8e
Autor:
Irit Vahav, Maria Thon, Lenie J. van den Broek, Sander W. Spiekstra, Beren Atac, Gerd Lindner, Katharina Schimek, Uwe Marx, Susan Gibbs
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1529 (2022)
Pharmaceutical and personal care industries require human representative models for testing to ensure the safety of their products. A major route of penetration into our body after substance exposure is via the skin. Our aim was to generate robust cu
Externí odkaz:
https://doaj.org/article/c31b3738084349dcbf9f4f9252f58cfa
Autor:
Janosch Schoon, Bernhard Hesse, Anastasia Rakow, Melanie J. Ort, Adrien Lagrange, Dorit Jacobi, Annika Winter, Katrin Huesker, Simon Reinke, Marine Cotte, Remi Tucoulou, Uwe Marx, Carsten Perka, Georg N. Duda, Sven Geissler
Publikováno v:
Advanced Science, Vol 7, Iss 20, Pp n/a-n/a (2020)
Abstract Metallic implants are frequently used in medicine to support and replace degenerated tissues. Implant loosening due to particle exposure remains a major cause for revision arthroplasty. The exact role of metal debris in sterile peri‐implan
Externí odkaz:
https://doaj.org/article/b46122ee60f140c1a289f4d0980d56dd
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Four integration-free iPSC lines were generated by reprogramming peripheral blood mononuclear cells with episomal vectors. All four human donors (two male and two female donors) belong to one Caucasian family within three different generations with t
Externí odkaz:
https://doaj.org/article/09a48395f5a54d2eafc3eb1858c4bd73