Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Uwe, Heinemann"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Stress is a biologically relevant signal and can modulate hippocampal synaptic plasticity. The subiculum is the major output station of the hippocampus and serves as a critical hub in the stress response network. However, stress-associated synaptic p
Externí odkaz:
https://doaj.org/article/efd20d88371f46d7910778ca9e35db7e
Autor:
Soo Young Kim, Vladimir V. Senatorov, Christapher S. Morrissey, Kristina Lippmann, Oscar Vazquez, Dan Z. Milikovsky, Feng Gu, Isabel Parada, David A. Prince, Albert J. Becker, Uwe Heinemann, Alon Friedman, Daniela Kaufer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes. Eme
Externí odkaz:
https://doaj.org/article/fbb888bc44be4410a0c2d072e5eab00a
Autor:
Seda Salar, Ezequiel Lapilover, Julia Müller, Jan-Oliver Hollnagel, Kristina Lippmann, Alon Friedman, Uwe Heinemann
Publikováno v:
Neurobiology of Disease, Vol 91, Iss , Pp 155-165 (2016)
Epileptogenesis following insults to the brain may be triggered by a dysfunctional blood-brain barrier (BBB) associated with albumin extravasation and activation of astrocytes. Using ex vivo recordings from the BBB-disrupted hippocampus after neocort
Externí odkaz:
https://doaj.org/article/f0dbeae1274f4801aa694ca5ac733189
Publikováno v:
Neurobiology of Disease, Vol 56, Iss , Pp 14-24 (2013)
In models of temporal lobe epilepsy, in-vitro exposure of the entorhinal cortex (EC) to low concentrations of acetylcholine (ACh) induces muscarinic-dependent seizure-like events. Potassium channels from the KCNQ/Kv7 family, which close upon activati
Externí odkaz:
https://doaj.org/article/e1e82fc79d494a81988eab630401ba8c
Autor:
Paul Gierke, CongJian Zhao, Hans-Gert Bernstein, Cornelia Noack, Rene Anand, Uwe Heinemann, Karl-Heinz Braunewell
Publikováno v:
Neurobiology of Disease, Vol 32, Iss 1, Pp 162-175 (2008)
Post mortem studies in the hippocampus of schizophrenia patients revealed increased expression of neuronal Ca2+-sensor VILIP-1 (visinin-like protein) and enhanced co-localization with α4β2 nAChR in interneurons. To study the pathological role of VI
Externí odkaz:
https://doaj.org/article/9f82887581a142698b24c8d3c7a7d17a
Autor:
Robert K. Zahn, Else A. Tolner, Christian Derst, Clemens Gruber, Rüdiger W. Veh, Uwe Heinemann
Publikováno v:
Neurobiology of Disease, Vol 29, Iss 2, Pp 186-200 (2008)
We investigated the potential of 4-AP (50–100 μM) to induce seizure-like events (SLEs) in combined entorhinal cortex–hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epi
Externí odkaz:
https://doaj.org/article/cc00e529564344c88da24c974c4d0d3d
Autor:
Else A. Tolner, Christiane Frahm, Robert Metzger, Jan A. Gorter, Otto W. Witte, Fernando H. Lopes da Silva, Uwe Heinemann
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 2, Pp 419-438 (2007)
Mesial temporal lobe epilepsy patients often display shrinkage of the entorhinal cortex, which has been attributed to neuronal loss in medial entorhinal cortex layer III (MEC-III). MEC-III neuronal loss is reproduced in chronic epileptic rats after k
Externí odkaz:
https://doaj.org/article/b67d4fe89ea24379830e37b8c7831aec
Autor:
Colin Kehrer, Tamar Dugladze, Nino Maziashvili, Anna Wójtowicz, Dietmar Schmitz, Uwe Heinemann, Tengis Gloveli
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 3, Pp 545-552 (2007)
The phencyclidine compound MK-801 can induce psychosis with symptoms which closely resemble those observed in an acute schizophrenic episode. Here we used an in vitro model of psychosis after systemic administration of MK-801. We found that kainate-i
Externí odkaz:
https://doaj.org/article/2df83ec456704dcb9a111f0fd80a9c6f
Autor:
Astrid Weber, Mark Dzietko, Monika Berns, Ursula Felderhoff-Mueser, Uwe Heinemann, Rolf F. Maier, Michael Obladen, Chrissanthi Ikonomidou, Christoph Bührer
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 594-600 (2005)
Both mild hypoxia and exogenous erythropoietin may protect the brain against subsequent severe hypoxia, and the conditioning effect of transient hypoxia is partly mediated by hypoxia-induced endogenous erythropoietin. We now observed in several exper
Externí odkaz:
https://doaj.org/article/9ec2941ff829409dba54f852ca50a45a
Publikováno v:
Neurobiology of Disease, Vol 13, Iss 3, Pp 203-212 (2003)
We studied the effect of kindling, a model of temporal lobe epilepsy, on the frequency-dependent information transfer from the entorhinal cortex to the hippocampus in vitro. In control rats repetitive synaptic activation of layer III projection cells
Externí odkaz:
https://doaj.org/article/250f3622aef84873b824bcf4130cf1cd