Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Uwe, Hansen"'
Autor:
Marit ten Hove, Andreas Smyris, Richell Booijink, Lydia Wachsmuth, Uwe Hansen, Lejla Alic, Cornelius Faber, Carsten Hӧltke, Ruchi Bansal
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 406-426 (2024)
Endothelin-1/endothelin A receptor (ET-1/ETAR) pathway plays an important role in the progression of liver fibrosis by activating hepatic stellate cells (HSCs) - a key cell type involved in the pathogenesis of liver fibrosis. Inactivating HSCs by blo
Externí odkaz:
https://doaj.org/article/116128a5ac164a989510fd0e761073b3
Autor:
Eugenie Werbenko, David J. J. de Gorter, Simon Kleimann, Denise Beckmann, Vanessa Waltereit-Kracke, Julia Reinhardt, Fabienne Geers, Peter Paruzel, Uwe Hansen, Thomas Pap, Theresia E. B. Stradal, Berno Dankbar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bone resorption is highly dependent on the dynamic rearrangement of the osteoclast actin cytoskeleton to allow formation of actin rings and a functional ruffled border. Hem1 is a hematopoietic-specific subunit of the WAVE-complex which regul
Externí odkaz:
https://doaj.org/article/7158c6618faa4174a45185de02e0dde3
Autor:
Suganja Chandrabalan, Linh Dang, Uwe Hansen, Melanie Timmen, Corinna Wehmeyer, Richard Stange, Tim Beißbarth, Claudia Binder, Annalen Bleckmann, Kerstin Menck
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract Background Osteoclasts are the tissue-specific macrophage population of the bone and unique in their bone-resorbing activity. Hence, they are fundamental for bone physiology in health and disease. However, efficient protocols for the isolati
Externí odkaz:
https://doaj.org/article/1c6c35f19f30456b964c2af20178a2ad
Autor:
Jingjun Tian, Veronika Hoffmann, Mohamed Gamal Ibrahim, Uwe Hansen, Andreas N. Schüring, Renata Voltolini Velho, Sylvia Mechsner, Martin Götte
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1355 (2024)
Adenomyosis (AM) is a gynecological disease characterized by the invasion of endometrial glands and stroma within the myometrium. The etiology and pathogenesis of AM remain inadequately understood. Pale cells were identified as a novel cell type char
Externí odkaz:
https://doaj.org/article/9aa58be7ef2144ddbc54ba300453ac46
Autor:
Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann, Kerstin Menck
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment. So far, EV uptake an
Externí odkaz:
https://doaj.org/article/2d48326b02b54a75a3384e4a27350f60
Autor:
Emily Hoffmann, Mirjam Gerwing, Tobias Krähling, Uwe Hansen, Katharina Kronenberg, Max Masthoff, Christiane Geyer, Carsten Höltke, Lydia Wachsmuth, Regina Schinner, Verena Hoerr, Walter Heindel, Uwe Karst, Michel Eisenblätter, Bastian Maus, Anne Helfen, Cornelius Faber, Moritz Wildgruber
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-16 (2023)
Abstract Background Response assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional morphological and volumetric analyses of tumor lesions. The tumor microenvironment is part
Externí odkaz:
https://doaj.org/article/bb457be90422403fb4b3cade4f355994
Autor:
Mirjam Gerwing, Emily Hoffmann, Katharina Kronenberg, Uwe Hansen, Max Masthoff, Anne Helfen, Christiane Geyer, Lydia Wachsmuth, Carsten Höltke, Bastian Maus, Verena Hoerr, Tobias Krähling, Lena Hiddeßen, Walter Heindel, Uwe Karst, Melanie A. Kimm, Regina Schinner, Michel Eisenblätter, Cornelius Faber, Moritz Wildgruber
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectiveThe objective of this study was to non-invasively differentiate the degree of malignancy in two murine breast cancer models based on identification of distinct tissue characteristics in a metastatic and non-metastatic tumor model using a mul
Externí odkaz:
https://doaj.org/article/107f5fb2d2b74102a992a5af89cfb498
Autor:
Denise Beckmann, Anja Römer-Hillmann, Annika Krause, Uwe Hansen, Corinna Wehmeyer, Johanna Intemann, David J. J. de Gorter, Berno Dankbar, Jan Hillen, Marianne Heitzmann, Isabell Begemann, Milos Galic, Toni Weinhage, Dirk Foell, Rizi Ai, Joachim Kremerskothen, Hans P. Kiener, Sylvia Müller, Thomas Kamradt, Christopher Schröder, Elsa Leitão, Bernhard Horsthemke, Philip Rosenstiel, Karl Nordström, Gilles Gasparoni, Nina Gasparoni, Jörn Walter, Na Li, Xinyi Yang, Ho-Ryun Chung, Hermann Pavenstädt, Nico Lindemann, Hans J. Schnittler, Wei Wang, Gary S. Firestein, Thomas Pap, Adelheid Korb-Pap
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in
Externí odkaz:
https://doaj.org/article/6eeabbe32b3249c9843c922ebc496340
Autor:
Ruiyuan Zhang, Ganesan Senthil Kumar, Uwe Hansen, Martina Zoccheddu, Cristiano Sacchetti, Zachary J. Holmes, Megan C. Lee, Denise Beckmann, Yutao Wen, Zbigniew Mikulski, Shen Yang, Eugenio Santelli, Rebecca Page, Francesco Boin, Wolfgang Peti, Nunzio Bottini
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Systemic sclerosis (SSc) is a fibrotic autoimmune disease characterized by pathogenic activation of fibroblasts enhanced by local oxidative stress. The tyrosine phosphatase PTP4A1 was identified as a critical promoter of TGF-β signaling in SSc. Oxid
Externí odkaz:
https://doaj.org/article/001f45b2204c49e390f35350bf24c3d6
Autor:
Christian Schwarz, Verena Hoerr, Yasemin Töre, Vanessa Hösker, Uwe Hansen, Hélène Van de Vyver, Silke Niemann, Michael T. Kuhlmann, Astrid Jeibmann, Moritz Wildgruber, Cornelius Faber
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Animal models of Staphylococcus aureus infective endocarditis (IE), especially in rodents, are commonly used to investigate the underlying pathogenesis, disease progression, potential diagnostic approaches, and therapeutic treatment. All these models
Externí odkaz:
https://doaj.org/article/868c8e406246455da16c847f6910094f