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Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma.

Autor: Heinrich VA; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Uvalle C; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, United States., Manni ML; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Li K; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA, United States., Mullett SJ; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, United States., Donepudi SR; Integrative Systems Biology Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Clader J; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA, United States., Fitch A; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA, United States., Ellgass M; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, United States., Cechova V; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Qin S; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA, United States.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Holguin F; Division of Pulmonary Sciences and Critical Care, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Freeman BA; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Methé BA; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA, United States.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Morris A; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA, United States.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, United States., Gelhaus SL; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, United States.

Publikováno v: Frontiers in microbiomes [Front Microbiomes] 2023; Vol. 2. Date of Electronic Publication: 2023 May 05.