Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Utz Herbig"'
Autor:
Tsung-Po Lai, Mark Simpson, Krunal Patel, Simon Verhulst, Jungsik Noh, Natalie Roche, Debra Heller, George Guirguis, Jerry W. Shay, Utz Herbig, Abraham Aviv
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Recent hypotheses propose that the human placenta and chorioamniotic membranes (CAMs) experience telomere length (TL)-mediated senescence. These hypotheses are based on mean TL (mTL) measurements, but replicative senescence is triggered by s
Externí odkaz:
https://doaj.org/article/13552a04d1b744908ff53b255f946d51
Autor:
Olga A Kovalenko, Jessica Kaplunov, Utz Herbig, Sonia Detoledo, Edouard I Azzam, Janine H Santos
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10812 (2010)
Telomerase is a reverse transcriptase associated with cellular immortality through telomere maintenance. This enzyme is activated in 90% of human cancers, and inhibitors of telomerase are currently in clinical trials to counteract tumor growth. Many
Externí odkaz:
https://doaj.org/article/b4d239414f4541bca81fa08303af2dff
Autor:
Ricardo Iván Martínez-Zamudio, Alketa Stefa, José Américo Nabuco, Themistoklis Vasilopoulos, Mark Simpson, Gregory Doré, Pierre-François Roux, Mark A. Galan, Ravi J. Chokshi, Oliver Bischof, Utz Herbig
Publikováno v:
Cell Genom
SummaryAlthough oncogene-induced senescence (OIS) is a potent tumor-suppressor mechanism, recent studies revealed that cells can escape from OIS with features of transformed cells. However, the mechanisms that promote OIS escape remain unclear, and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf97590f55c69f78802b8559bf393d
https://europepmc.org/articles/PMC10112333/
https://europepmc.org/articles/PMC10112333/
Autor:
David M. Ashley, Gao Zhang, Kalil Abdullah, Jerry W. Shay, Kongming Wu, Lunxu Liu, Keith Flaherty, Stephen T. Keir, Zhi Wei, Utz Herbig, Gordon Mills, Meenhard Herlyn, Yiling Lu, Kyle M. Walsh, Mustafa Khasraw, Edward Pan, Roger E. McLendon, Wen Jiang, Matthew Waitkus, Seethalakshmi Hariharan, Michelle Bowie, Eric Sugarman, Casey M. Charbonneau, Marilyne Labrie, Yaohui Chen, Meng Tian, Hao Liu, Di Wu, Yin Ku, Zachary J. Reitman, Themistoklis Vasilopoulos, Silvia Siteni, Ilgen Mender, Kuang Du, Xiang Lin, Milan Savani, Shiyou Wei, Shengnan Yu
Supplementary Figure 1. (A-B) Successful labeling of CellTrace Violet for M059K and H4 cells. M059K and H4 cells were labeled with a cell membrane dye CellTrace Violet and verified the success of labeling by FACS. (C-D) Cell viability of M059K and H4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b67de367e12ada341397828d118d525
https://doi.org/10.1158/1078-0432.22483260.v1
https://doi.org/10.1158/1078-0432.22483260.v1
Autor:
David M. Ashley, Gao Zhang, Kalil Abdullah, Jerry W. Shay, Kongming Wu, Lunxu Liu, Keith Flaherty, Stephen T. Keir, Zhi Wei, Utz Herbig, Gordon Mills, Meenhard Herlyn, Yiling Lu, Kyle M. Walsh, Mustafa Khasraw, Edward Pan, Roger E. McLendon, Wen Jiang, Matthew Waitkus, Seethalakshmi Hariharan, Michelle Bowie, Eric Sugarman, Casey M. Charbonneau, Marilyne Labrie, Yaohui Chen, Meng Tian, Hao Liu, Di Wu, Yin Ku, Zachary J. Reitman, Themistoklis Vasilopoulos, Silvia Siteni, Ilgen Mender, Kuang Du, Xiang Lin, Milan Savani, Shiyou Wei, Shengnan Yu
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a7426631ce3a265093a1f02348bfc5
https://doi.org/10.1158/1078-0432.22483269
https://doi.org/10.1158/1078-0432.22483269
Autor:
Jerry W. Shay, Meenhard Herlyn, Keith T. Flaherty, Gordon B. Mills, Utz Herbig, Katherine Nathanson, Zhi Wei, Genevieve M. Boland, Yiling Lu, Ravi K. Amaravadi, Lawrence N. Kwong, Tara C. Mitchell, Lynn M. Schuchter, Xiaowei Xu, Giorgos C. Karakousis, Wei Xu, Benchun Miao, Dennie T. Frederick, Qin Liu, Xiangfan Yin, Jonathan Woo, Bradley Wubbenhorst, Bradley Garman, Rajasekharan Somasundaram, Sengottuvelan Murugan, Katrin Sproesser, Patricia Brafford, Clemens Krepler, Eric Sugarman, Umar Saeed, Jiufeng Tan, Tian Tian, Min Xiao, Aurelie Beroard, Norah Sadek, Sergio Randell, Themistoklis Vasilopoulos, Chaoran Cheng, Omotayo Ope, Marc R. Hammond, Michal Barzily-Rokni, Ilgen Mender, Lawrence W. Wu, Gao Zhang
Time-lapse imaging of A375(Fucci2)-BR cells treated with the control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0400f86ce98f17acabe362f98d673c
https://doi.org/10.1158/1078-0432.22464027
https://doi.org/10.1158/1078-0432.22464027
Autor:
David M. Ashley, Gao Zhang, Kalil Abdullah, Jerry W. Shay, Kongming Wu, Lunxu Liu, Keith Flaherty, Stephen T. Keir, Zhi Wei, Utz Herbig, Gordon Mills, Meenhard Herlyn, Yiling Lu, Kyle M. Walsh, Mustafa Khasraw, Edward Pan, Roger E. McLendon, Wen Jiang, Matthew Waitkus, Seethalakshmi Hariharan, Michelle Bowie, Eric Sugarman, Casey M. Charbonneau, Marilyne Labrie, Yaohui Chen, Meng Tian, Hao Liu, Di Wu, Yin Ku, Zachary J. Reitman, Themistoklis Vasilopoulos, Silvia Siteni, Ilgen Mender, Kuang Du, Xiang Lin, Milan Savani, Shiyou Wei, Shengnan Yu
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870c47a2d8ebe7eeca098bdd8af9a32a
https://doi.org/10.1158/1078-0432.22483272.v1
https://doi.org/10.1158/1078-0432.22483272.v1
Autor:
David M. Ashley, Gao Zhang, Kalil Abdullah, Jerry W. Shay, Kongming Wu, Lunxu Liu, Keith Flaherty, Stephen T. Keir, Zhi Wei, Utz Herbig, Gordon Mills, Meenhard Herlyn, Yiling Lu, Kyle M. Walsh, Mustafa Khasraw, Edward Pan, Roger E. McLendon, Wen Jiang, Matthew Waitkus, Seethalakshmi Hariharan, Michelle Bowie, Eric Sugarman, Casey M. Charbonneau, Marilyne Labrie, Yaohui Chen, Meng Tian, Hao Liu, Di Wu, Yin Ku, Zachary J. Reitman, Themistoklis Vasilopoulos, Silvia Siteni, Ilgen Mender, Kuang Du, Xiang Lin, Milan Savani, Shiyou Wei, Shengnan Yu
Purpose:To investigate the therapeutic role of a novel telomere-directed inhibitor, 6-thio-2′-deoxyguanosine (THIO) in gliomas both in vitro and in vivo.Experimental Design:A panel of human and mouse glioma cell lines was used to test therapeutic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8d8a83ab882dde8aa89d0300de4b39
https://doi.org/10.1158/1078-0432.c.6531102
https://doi.org/10.1158/1078-0432.c.6531102
Autor:
David M. Ashley, Gao Zhang, Kalil Abdullah, Jerry W. Shay, Kongming Wu, Lunxu Liu, Keith Flaherty, Stephen T. Keir, Zhi Wei, Utz Herbig, Gordon Mills, Meenhard Herlyn, Yiling Lu, Kyle M. Walsh, Mustafa Khasraw, Edward Pan, Roger E. McLendon, Wen Jiang, Matthew Waitkus, Seethalakshmi Hariharan, Michelle Bowie, Eric Sugarman, Casey M. Charbonneau, Marilyne Labrie, Yaohui Chen, Meng Tian, Hao Liu, Di Wu, Yin Ku, Zachary J. Reitman, Themistoklis Vasilopoulos, Silvia Siteni, Ilgen Mender, Kuang Du, Xiang Lin, Milan Savani, Shiyou Wei, Shengnan Yu
Supplementary Figure 1. (A-B) Successful labeling of CellTrace Violet for M059K and H4 cells. M059K and H4 cells were labeled with a cell membrane dye CellTrace Violet and verified the success of labeling by FACS. (C-D) Cell viability of M059K and H4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c8e4f5fdcbe655133a558635de3072
https://doi.org/10.1158/1078-0432.22483266
https://doi.org/10.1158/1078-0432.22483266
Autor:
Jerry W. Shay, Meenhard Herlyn, Keith T. Flaherty, Gordon B. Mills, Utz Herbig, Katherine Nathanson, Zhi Wei, Genevieve M. Boland, Yiling Lu, Ravi K. Amaravadi, Lawrence N. Kwong, Tara C. Mitchell, Lynn M. Schuchter, Xiaowei Xu, Giorgos C. Karakousis, Wei Xu, Benchun Miao, Dennie T. Frederick, Qin Liu, Xiangfan Yin, Jonathan Woo, Bradley Wubbenhorst, Bradley Garman, Rajasekharan Somasundaram, Sengottuvelan Murugan, Katrin Sproesser, Patricia Brafford, Clemens Krepler, Eric Sugarman, Umar Saeed, Jiufeng Tan, Tian Tian, Min Xiao, Aurelie Beroard, Norah Sadek, Sergio Randell, Themistoklis Vasilopoulos, Chaoran Cheng, Omotayo Ope, Marc R. Hammond, Michal Barzily-Rokni, Ilgen Mender, Lawrence W. Wu, Gao Zhang
Table S1 Mean density values of crystal violet staining of 16 melanoma cell lines treated with 6-thio-dG and PLX4720. Table S2 RNA-seq data related to A375 cells treated with 6-thio-dG. Table S3 RNA-seq data related to A375 cells treated with BIBR 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2a7a2c06234a8e0c4e1e6e36a755fd
https://doi.org/10.1158/1078-0432.22464015.v1
https://doi.org/10.1158/1078-0432.22464015.v1