Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Uttam Surana"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Chromosomes are susceptible to damage during their duplication and segregation or when exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic instability, leading to cells’ diminished fitness, unbridled proliferation o
Externí odkaz:
https://doaj.org/article/58d40a3ee47d42829d9d2f2aff33f689
Autor:
Olivia X. Ma, Wen Guan Chong, Joy K. E. Lee, Shujun Cai, C. Alistair Siebert, Andrew Howe, Peijun Zhang, Jian Shi, Uttam Surana, Lu Gan
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
In meiosis, cells undergo two sequential rounds of cell division, termed meiosis I and meiosis II. Textbook models of the meiosis I substage called pachytene show that nuclei have conspicuous 100-nm-wide, ladder-like synaptonemal complexes and ordere
Externí odkaz:
https://doaj.org/article/b7d434add7484171a99034f77fcfd162
Publikováno v:
Indian Journal of Dermatology, Vol 64, Iss 5, Pp 400-403 (2019)
Blau syndrome (BS) is a very rare autosomal dominant juvenile inflammatory disorder caused by mutation in nucleotide-binding oligomerization domain containing 2 (NOD2). Usually, dermatitis is the first symptom that appears in the 1styear of life. Abo
Externí odkaz:
https://doaj.org/article/3d839b0f64d9498a8c869686bdd237c9
Autor:
Jing Lin, Jia Hui Jane Lee, Kathirvel Paramasivam, Elina Pathak, Zhenxun Wang, Zacharias Aloysius Dwi Pramono, Bing Lim, Keng Boon Wee, Uttam Surana
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 263-273 (2017)
Self-renewing tumor-initiating cells (TICs) are thought to be responsible for tumor recurrence and chemo-resistance. Glycine decarboxylase, encoded by the GLDC gene, is reported to be overexpressed in TIC-enriched primary non-small-cell lung carcinom
Externí odkaz:
https://doaj.org/article/14979fe742534762afeed8b2e3cefe64
Autor:
Zhisheng Her, Kylie Su Mei Yong, Kathirvel Paramasivam, Wilson Wei Sheng Tan, Xue Ying Chan, Sue Yee Tan, Min Liu, Yong Fan, Yeh Ching Linn, Kam Man Hui, Uttam Surana, Qingfeng Chen
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background Xenotransplantation of patient-derived AML (acute myeloid leukemia) cells in NOD-scid Il2rγ null (NSG) mice is the method of choice for evaluating this human hematologic malignancy. However, existing models constructed using intr
Externí odkaz:
https://doaj.org/article/5dba0c5841194d29b57f35311e8215c6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2019)
Targeting the mitotic pathways of rapidly proliferating tumor cells has been an effective strategy in traditional cancer therapy. Chemotherapeutics such as taxanes and vinca alkaloids, which disrupt microtubule function, have enjoyed clinical success
Externí odkaz:
https://doaj.org/article/2acea77d6cb64894a7ce4096278015cf
Autor:
Haojie Yu, Hong Hwa Lim, Natalia O. Tjokro, Padmapriya Sathiyanathan, Suchitra Natarajan, Tian Wei Chew, Thomas Klonisch, Steven D. Goodman, Uttam Surana, Peter Dröge
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 684-697 (2014)
Maintaining genome integrity requires the accurate and complete replication of chromosomal DNA. This is of the utmost importance for embryonic stem cells (ESCs), which differentiate into cells of all lineages, including germ cells. However, endogenou
Externí odkaz:
https://doaj.org/article/e0c0f79bc2d94e02a34db0d3f595b528
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4407 (2009)
Intracellular protein levels of p53 and MDM2 have been shown to oscillate in response to ionizing radiation (IR), but the physiological significance of these oscillations remains unclear. The p53-MDM2 negative feedback loop -- the putative cause of t
Externí odkaz:
https://doaj.org/article/773cb0b257df47a0aaa38708f361dfe6
Publikováno v:
Nucleic Acids Research
The DNA damage checkpoint halts cell cycle progression in G2 in response to genotoxic insults. Central to the execution of cell cycle arrest is the checkpoint-induced stabilization of securin-separase complex (yeast Pds1-Esp1). The checkpoint kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e041a4167b7a1c58a41e492a7eaf456
https://doi.org/10.1093/nar/gkaa355
https://doi.org/10.1093/nar/gkaa355
