Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Uttam SHARMA"'
The miRNA and PD-1/PD-L1 signaling axis: an arsenal of immunotherapeutic targets against lung cancer
Autor:
Ritu Yadav, Rinku Khatkar, Kenneth C-H Yap, Chloe Yun-Hui Kang, Juncheng Lyu, Rahul Kumar Singh, Surojit Mandal, Adrija Mohanta, Hiu Yan Lam, Elena Okina, Rajiv Ranjan Kumar, Vivek Uttam, Uttam Sharma, Manju Jain, Hridayesh Prakash, Hardeep Singh Tuli, Alan Prem Kumar, Aklank Jain
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-19 (2024)
Abstract Lung cancer is a severe challenge to the health care system with intrinsic resistance to first and second-line chemo/radiotherapies. In view of the sterile environment of lung cancer, several immunotherapeutic drugs including nivolumab, pemb
Externí odkaz:
https://doaj.org/article/8d24362bca0a4f9ab5e76ee509aef09c
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 1, Pp 1-11 (2024)
The widespread public health problem of esophageal squamous cell carcinoma (ESCC) is the cause of an increasing number of deaths each year due to delayed diagnosis. Therefore, we require specific and sensitive new biomarkers to manage ESCC better. Th
Externí odkaz:
https://doaj.org/article/bca2f41c748f4976b7f1dc524c995cc4
Autor:
Priyanka Madaan, Uttam Sharma, Nipanshi Tyagi, Balvinder Kaur Brar, Shivani Bansal, Hemant Rituraj Kushwaha, Harmanpreet Singh Kapoor, Aklank Jain, Manju Jain
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Psoriasis is a chronic inflammatory skin disease with keratinocyte hyperproliferation and T cells as key mediators of lesional and systemic inflammatory changes. To date, no suitable differential biomarkers are available for the disease diagnosis. Mo
Externí odkaz:
https://doaj.org/article/3b43bfa13f7a4b1182b28bb00434fdd6
Autor:
Uttam Sharma, Masang Murmu, Tushar Singh Barwal, Hardeep Singh Tuli, Manju Jain, Hridayesh Prakash, Tea Kaceli, Aklank Jain, Anupam Bishayee
Publikováno v:
Current Oncology, Vol 29, Iss 4, Pp 2326-2349 (2022)
Despite the availability of modern techniques for the treatment of esophageal squamous cell carcinoma (ESCC), tumor recurrence and metastasis are significant challenges in clinical management. Thus, ESCC possesses a poor prognosis and low five-year o
Externí odkaz:
https://doaj.org/article/c4473179253a4245a015c165a7591266
Autor:
Hardeep Singh Tuli, Katrin Sak, Vivek Kumar Garg, Ajay Kumar, Shubham Adhikary, Ginpreet Kaur, Nidarshana Chaturvedi Parashar, Gaurav Parashar, Tapan Kumar Mukherjee, Uttam Sharma, Aklank Jain, Ranjan K. Mohapatra, Kuldeep Dhama, Manoj Kumar, Tejveer Singh
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1614-1623 (2022)
Cancer is being considered as a serious threat to human health globally due to limited availability and efficacy of therapeutics. In addition, existing chemotherapeutic drugs possess a diverse range of toxic side effects. Therefore, more research is
Externí odkaz:
https://doaj.org/article/bc2ed999d1b84688a7b9693e07586624
Autor:
Hardeep Singh Tuli, Vivek Kumar Garg, Sakshi Bhushan, Vivek Uttam, Uttam Sharma, Aklank Jain, Katrin Sak, Vikas Yadav, Jose M. Lorenzo, Kuldeep Dhama, Tapan Behl, Gautam Sethi
Publikováno v:
Translational Oncology, Vol 27, Iss , Pp 101596- (2023)
Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this drea
Externí odkaz:
https://doaj.org/article/742afcb4071f4fffaa2a379037ed31dc
Autor:
Pawan Kumar, Ram Kumar Kumawat, Vivek Uttam, Alisha Behera, Medha Rani, Neha Singh, Tushar Singh Barwal, Uttam Sharma, Aklank Jain
Publikováno v:
Translational Oncology, Vol 27, Iss , Pp 101573- (2023)
Unfortunately, despite the severe problem associated with salivary adenoid cystic carcinoma (SACC), it has not been studied in detail yet. Therefore, the time has come to understand the oncogenic cause of SACC and find the correct molecular markers f
Externí odkaz:
https://doaj.org/article/f57948632ad44ebd9f394b42f6b603dc
Autor:
Uttam Sharma, Tushar Singh Barwal, Akanksha Khandelwal, Manjit Kaur Rana, Amrit Pal Singh Rana, Karuna Singh, Aklank Jain
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundDespite the availability of advanced technology to detect and treat esophageal squamous cell carcinoma (ESCC), the 5-year survival rate of ESCC patients is still meager. Recently, long non-coding RNAs (lncRNAs) have emerged as essential pla
Externí odkaz:
https://doaj.org/article/eac54602e8b044929783f4732b0f2532
Publikováno v:
International Journal of Breast Cancer, Vol 2022 (2022)
Background. The frozen section (FS) has been a good technique in surgical management of breast lesions since many years. But complete agreement and cooperation have not been achieved everywhere among surgeons and pathologists especially in the develo
Externí odkaz:
https://doaj.org/article/e2c6baf4adef45cabe6486ea88cb834a
Autor:
Tushar Singh Barwal, Neha Singh, Uttam Sharma, Sonali Bazala, Medha Rani, Alisha Behera, Ram Kumar Kumawat, Pawan Kumar, Vivek Uttam, Akanksha Khandelwal, Jyoti Barwal, Manju Jain, Aklank Jain
Publikováno v:
Cancer Treatment and Research Communications, Vol 32, Iss , Pp 100593- (2022)
Accumulating evidence suggests the critical role of miR-590–5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590–5p acts as an oncogene in some cancers while it acts
Externí odkaz:
https://doaj.org/article/2e17e317ad5a449ba8c135e82f17dbc0