Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Uttam B. Karale"'
Autor:
Grace Kaul, Uttam B Karale, Abdul Akhir, Manjulika Shukla, Deepanshi Saxena, Haridas B Rode, Sidharth Chopra
Publikováno v:
Future Microbiology. 17:1475-1486
Background: Drug repurposing is a viable approach to expediting the tedious conventional drug discovery process, given rapidly increasing bacterial resistance. In this context, we have repurposed pyrvinium pamoate (PP) for its antibacterial activity
Publikováno v:
The Journal of Organic Chemistry. 87:2435-2445
A Selectfluor-mediated approach for the synthesis of β-acyl allyl sulfones/β-acyl allyl benzotriazoles with excellent atom economy from readily available acetophenones/aryl acetylenes, aryl sulfinates/benzotriazoles, and dimethyl sulfoxide (DMSO) i
Autor:
Grace, Kaul, Uttam B, Karale, Abdul, Akhir, Manjulika, Shukla, Deepanshi, Saxena, Haridas B, Rode, Sidharth, Chopra
Publikováno v:
Future microbiology. 17
Treatment of drug-resistant bacterial infections urgently requires novel antibiotic combinations that can help in reducing the dose of antibiotic required as well as decreasing the emergence of resistance. In this context, pyrvinium pamoate is active
Publikováno v:
ChemistrySelect. 3:5639-5643
Autor:
Surender Singh Jadav, Vamshi K. Eruva, Siva Krishna Vagolu, Sriram Dharmarajan, Komal G. Sangu, Dattatraya A. Babar, Haridas B. Rode, Uttam B. Karale, Sunil Misra, Akash U. Shinde
Publikováno v:
Archiv der Pharmazie. 354:2000419
Novel inhibitors are needed to tackle tuberculosis. Herein, we report the 3-aryl-substituted imidazo[1,2-a]pyridines as potent antituberculosis agents. A small library of 3-aryl-substituted imidazo[1,2-a]pyridines was synthesized using direct arylati
Publikováno v:
Tetrahedron Letters. 58:2818-2821
Autor:
E. Vamshi Krishna, Uttam B. Karale, B. Mahizhaveni, Vagolu Siva Krishna, Vikas R. Gaikwad, Manjulika Shukla, Dhiman Sarkar, Haridas B. Rode, V.N. Azger Dusthackeer, Dharmarajan Sriram, Sidharth Chopra, Sunil Misra, Amit S. Choudhari
Publikováno v:
European journal of medicinal chemistry. 178
The dormant and resistant form of Mycobacterium tuberculosis presents a challenge in developing new anti-tubercular drugs. Herein, we report the synthesis and evaluation of trisubstituted thiazoles as antituberculosis agents. The SAR study has identi
Autor:
Uttam B. Karale, Saradhi Kalari, Sidharth Chopra, Dattatraya A. Babar, Jala Shivakumar, Vitthal B. Makane, Haridas B. Rode, Ritesh P. Thakare, Bathini Nagendra Babu
Publikováno v:
RSC Advances. 6:65095-65104
A facile ligand-free method for Pd(OAc)2 catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with hetero(aryl) bromides has been developed. This method is applicable to a variety of (hetero)aryl bromides as coupling partn
Autor:
Puran Sigh Sijwali, Vagolu Siva Krishna, E. Vamshi Krishna, Gokulapriya Govindarajalu, Sunil Misra, Haridas B. Rode, Navin Adhikari, Dharmarajan Sriram, Vikas R. Gaikwad, Uttam B. Karale
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127037
Herein, we report the synthesis and evaluation of pyrvinium-based antimalarial and antitubercular compounds. Pyrvinium is an FDA approved drug for the treatment of pinworm infection, and it has been reported to have antiparasitic and antimicrobial ac
Autor:
Haridas B. Rode, Jala Shivakumar, Bathini Nagendra Babu, Sidharth Chopra, Dattatraya A. Babar, Uttam B. Karale, Saradhi Kalari, Vitthal B. Makane, Ritesh P. Thakare
Publikováno v:
ChemInform. 47