Broadly neutralizing antibodies target a haemagglutinin anchor epitope.

Autor: Guthmiller JJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA. jguthmiller@uchicago.edu., Han J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Utset HA; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA., Li L; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA., Lan LY; Committee on Immunology, University of Chicago, Chicago, IL, USA., Henry C; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.; Moderna Inc., Cambridge, MA, USA., Stamper CT; Committee on Immunology, University of Chicago, Chicago, IL, USA., McMahon M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., O'Dell G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fernández-Quintero ML; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Freyn AW; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Moderna Inc., Cambridge, MA, USA., Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stovicek O; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA., Gentles L; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Microbiology, University of Washington, Seattle, WA, USA., Richey ST; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., de la Peña AT; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Rosado V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dugan HL; Committee on Immunology, University of Chicago, Chicago, IL, USA., Zheng NY; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA., Tepora ME; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA., Bitar DJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA., Changrob S; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA., Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Huang M; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Liedl KR; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Bloom JD; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Microbiology, University of Washington, Seattle, WA, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Nachbagauer R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Moderna Inc., Cambridge, MA, USA., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Coughlan L; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.; Center for Vaccine Development and Global Health (CVD), University of Maryland School of Medicine, Baltimore, MD, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. andrew@scripps.edu., Wilson PC; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA. pcw4001@med.cornell.edu.; Committee on Immunology, University of Chicago, Chicago, IL, USA. pcw4001@med.cornell.edu.; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. pcw4001@med.cornell.edu.

Publikováno v: Nature [Nature] 2022 Feb; Vol. 602 (7896), pp. 314-320. Date of Electronic Publication: 2021 Dec 23.

Improved integration of single-cell transcriptome and surface protein expression by LinQ-View.

Autor: Li L; University of Chicago Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA., Dugan HL; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Stamper CT; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Lan LY; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Asby NW; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Knight M; University of Chicago Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA., Stovicek O; University of Chicago Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA., Zheng NY; University of Chicago Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA., Madariaga ML; Department of Surgery, University of Chicago, Chicago, IL 60637, USA., Shanmugarajah K; Department of Surgery, University of Chicago, Chicago, IL 60637, USA., Jansen MO; Section of Hospital Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA., Changrob S; University of Chicago Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA., Utset HA; University of Chicago Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA., Henry C; University of Chicago Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA., Nelson C; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Jedrzejczak RP; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA., Fremont DH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Joachimiak A; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Huang J; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Khan AA; Department of Pathology, University of Chicago, Chicago, IL 60637, USA., Wilson PC; University of Chicago Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA.; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.

Publikováno v: Cell reports methods [Cell Rep Methods] 2021 Jul 23; Vol. 1 (4), pp. 100056. Date of Electronic Publication: 2021 Jul 23 (Print Publication: 2021).

An Egg-Derived Sulfated N -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines.

Autor: Guthmiller JJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Utset HA; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Henry C; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Li L; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Zheng NY; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Sun W; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Costa Vieira M; Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA., Zost S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Huang M; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Hensley SE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Cobey S; Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Wilson PC; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.

Publikováno v: MBio [mBio] 2021 Jun 29; Vol. 12 (3), pp. e0083821. Date of Electronic Publication: 2021 Jun 15.

First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes.

Autor: Guthmiller JJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA. jguthmiller@uchicago.edu andrew@scripps.edu wilsonp@uchicago.edu., Han J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Li L; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Freyn AW; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Liu STH; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Stovicek O; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Stamper CT; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Dugan HL; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Tepora ME; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Utset HA; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Bitar DJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Hamel NJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Changrob S; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Zheng NY; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Huang M; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Nachbagauer R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. jguthmiller@uchicago.edu andrew@scripps.edu wilsonp@uchicago.edu., Wilson PC; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA. jguthmiller@uchicago.edu andrew@scripps.edu wilsonp@uchicago.edu.; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Jun 02; Vol. 13 (596).

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses.

Autor: Guthmiller JJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Lan LY; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Fernández-Quintero ML; Center for Molecular Biosciences Innsbruck, Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, 6020 Innsbruck, Austria., Han J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Utset HA; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Bitar DJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Hamel NJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Stovicek O; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Li L; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Tepora M; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Henry C; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Neu KE; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Dugan HL; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Borowska MT; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA., Chen YQ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Liu STH; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Stamper CT; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Zheng NY; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Huang M; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., Palm AE; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Nachbagauer R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Coughlan L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Microbiology and Immunology and Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Liedl KR; Center for Molecular Biosciences Innsbruck, Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, 6020 Innsbruck, Austria., Wilson PC; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. Electronic address: wilsonp@uchicago.edu.

Publikováno v: Immunity [Immunity] 2020 Dec 15; Vol. 53 (6), pp. 1230-1244.e5. Date of Electronic Publication: 2020 Oct 22.