Výsledky vyhledávání - "Utsav H. Saxena"

Transcription factors LSF and E2Fs: Tandem cyclists driving G0 to S?

Autor: Laura Owens, Ulla Hansen, Utsav H. Saxena

Publikováno v: Cell Cycle. 8:2146-2151

Cell cycle progression in mammalian cells from G(1) into S phase requires sensing and integration of multiple inputs, in order to determine whether to continue to cellular DNA replication and subsequently, to cell division. Passage to S requires tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ecd7c95b968c70b07e45747d383f73
https://doi.org/10.4161/cc.8.14.9089

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Prolyl Isomerase Pin1 Regulates Transcription Factor LSF (TFCP2) by Facilitating Dephosphorylation at Two Serine-Proline Motifs*

Autor: Ulla Hansen, Geoffrey M. Cooper, Laura Owens, Julie R. Graham, Utsav H. Saxena

Transcription factor LSF is essential for cell cycle progression, being required for activating expression of the thymidylate synthase (Tyms) gene at the G1/S transition. We previously established that phosphorylation of LSF in early G1 at Ser-291 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54bde04ef39178c859532a12fd2266c
https://europepmc.org/articles/PMC2951187/

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Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma

Autor: Christine E. Fuller, Kimberly H. Jones, Rachel Gredler, Catherine I. Dumur, Devanand Sarkar, Luni Emdad, Byoung Kwon Yoo, Paul B. Fisher, Colleen Jackson-Cook, Zao-Zhong Su, Utsav H. Saxena, Ulla Hansen, Dong Chen

Hepatocellular carcinoma (HCC) is a highly aggressive cancer with no currently available effective treatment. Understanding of the molecular mechanism of HCC development and progression is imperative for developing novel, effective, and targeted ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f35c2f71be53a2a89612fda4ad0274e
https://europepmc.org/articles/PMC2889542/

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Identification of genes conferring resistance to 5-fluorouracil

Autor: Utsav H. Saxena, Dong Chen, Zao-Zhong Su, Byoung Kwon Yoo, Talitha Forcier, Devanand Sarkar, Paul B. Fisher, Nicollaq Vozhilla, Ulla Hansen, Khalid Shah, Rachel Gredler

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 106(31)

Astrocyte elevated gene-1 (AEG-1) is overexpressed in >90% of human hepatocellular carcinoma (HCC) patients and plays a significant role in mediating aggressive progression of HCC. AEG-1 is known to augment invasion, metastasis, and angiogenesis, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e3589a857042fd859ab7fc538b7e56
https://pubmed.ncbi.nlm.nih.gov/19622726

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Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression

Autor: Roxanne Cacioppo, Hubert S. Chou, Christina M. H. Powell, Ulla Hansen, Jill K. Fecko, Geoffrey M. Cooper, Utsav H. Saxena

Publikováno v: Molecular and cellular biology. 29(9)

Transcription factor LSF is required for progression from quiescence through the cell cycle, regulating thymidylate synthase (Tyms) expression at the G(1)/S boundary. Given the constant level of LSF protein from G(0) through S, we investigated whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12f78a99fd75f6448befc2c0d992ddc
https://pubmed.ncbi.nlm.nih.gov/19237534

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