Zobrazeno 1 - 10
of 4 328
pro vyhledávání: '"Utr"'
Autor:
Aneela Mustafa, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Fizzah Abid, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Variations in untranslated regions (UTR) alter regulatory pathways impacting phenotype, disease onset, and course of disease. Protein kinase C Zeta (PRKCZ), a serine-threonine kinase, is implicated in cardiovascular, neurological
Externí odkaz:
https://doaj.org/article/26f43689afa74e5cbf7f1e4a28e45a0a
Autor:
Neeti Nadda, Renu Yadav, Neelanjana Roy, Nita Singh, Sonu Kumar, Shashi Bala Paul, Shivanand Gamanagatti, Anoop Saraya, Shalimar, Baibaswata Nayak
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundHuman leukocyte antigen-G (HLA-G) is a cancer-associated immune checkpoint protein implicated in tumor-driven immune escape mechanisms. This study was undertaken to determine genetic variations at the 3’-UTR of the HLA-G gene that may alt
Externí odkaz:
https://doaj.org/article/b2f28af35dab4162857a9b87a28aae00
Publikováno v:
In Supramolecular Materials December 2024 3
Publikováno v:
In Critical Reviews in Oncology / Hematology February 2025 206
Autor:
Xiaoshan Tang, Miaozhe Huo, Yuting Chen, Hai Huang, Shugang Qin, Jiaqi Luo, Zeyi Qin, Xin Jiang, Yongmei Liu, Xing Duan, Ruohan Wang, Lingxi Chen, Hao Li, Na Fan, Zhongshan He, Xi He, Bairong Shen, Shuai Cheng Li, Xiangrong Song
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1814-1826 (2024)
Efficient translation mediated by the 5′ untranslated region (5′ UTR) is essential for the robust efficacy of mRNA vaccines. However, the N1-methyl-pseudouridine (m1Ψ) modification of mRNA can impact the translation efficiency of the 5′ UTR. W
Externí odkaz:
https://doaj.org/article/86ce24bef18c4089ae453704e1c42e55
Autor:
Tianru Zhang, Changhao Li, Jiaying Zhu, Yanjun Li, Zhiye Wang, Chun-Yip Tong, Yu Xi, Yi Han, Hisashi Koiwa, Xu Peng, Xiuren Zhang
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-31 (2024)
Abstract Background RNA secondary structure (RSS) can influence the regulation of transcription, RNA processing, and protein synthesis, among other processes. 3′ untranslated regions (3′ UTRs) of mRNA also hold the key for many aspects of gene re
Externí odkaz:
https://doaj.org/article/cce8238e71cf407d8e1a085baa61602d
Autor:
Sara Esther Ramos-Lorente, Beatriz Berzal-Herranz, Cristina Romero-López, Alfredo Berzal-Herranz
Publikováno v:
Virus Research, Vol 343, Iss , Pp 199340- (2024)
Flaviviral RNA genomes are composed of discrete RNA structural units arranged in an ordered fashion and grouped into complex folded domains that regulate essential viral functions, e.g. replication and translation. This is achieved by adjusting the o
Externí odkaz:
https://doaj.org/article/4188eac997214cc1a558923c968b2f73
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-15 (2024)
Abstract Background The 5´ untranslated region (5´ UTR) plays a key role in regulating translation efficiency and mRNA stability, making it a favored target in genetic engineering and synthetic biology. A common feature found in the 5´ UTR is the
Externí odkaz:
https://doaj.org/article/a18506c7e8cf4b8d8d21ec074347e48a
Autor:
Muhammad Safdar, PhD, Mehmet Ozaslan, PhD, Rebaz M. Mustafa, MSC, Shukur W. Smail, MSC, Samiha S. Khan, MBBS, Muhammad Sajjad Khan, PhD, Muhammad Asad Akhtar, MSC, Hafiz Khawar Ali, MSC, Umair Younas, PhD, Muhammad Saeed, PhD, Faisal Siddique, PhD, Muhammad Naveed, PhD, SaifUr Rehman, PhD
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 18, Iss 5, Pp 1030-1047 (2023)
الملخص: أهداف البحث: يستهدف فيروس كورونا سارس-2 مستقبل الإنزيم المحول للمستضد 2، مما يؤدي إلى ارتفاع معدلات الإصابة بالأمراض وزيادة خطر ال
Externí odkaz:
https://doaj.org/article/e297b5eedae6410aa03a94bac0563d1e
Publikováno v:
Virus Research, Vol 341, Iss , Pp 199309- (2024)
Newcastle disease virus (NDV) is an avian virus and a promising vector for the development of vaccines for veterinary and human use. The optimal vaccine vector performance requires a stable high-level expression of a transgene. The foreign genes are
Externí odkaz:
https://doaj.org/article/20c42b5747184ad5897f8619b6577a7b