Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Uththara Liyanagunawardana"'
Autor:
Ueli Gubler, Uththara Liyanagunawardana, Thomas Candela, Nina M. Goodey, Jaclyn Catalano, Natalia E. Reis, Michael Little, Katherine Leon H, Tyler Eck, Seema Patel, Cheryl A. Janson
Publikováno v:
Archives of Biochemistry and Biophysics. 692:108545
Many antibacterial and antiparasitic drugs work by competitively inhibiting dihydrofolate reductase (DHFR), a vital enzyme in folate metabolism. The interactions between inhibitors and DHFR active site residues are known in many homologs but the cont