A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.

Autor: Schmidt S; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany., Gay D; CRUK Beatson Institute, Glasgow, UK., Uthe FW; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany., Denk S; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany., Paauwe M; CRUK Beatson Institute, Glasgow, UK., Matthes N; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany., Diefenbacher ME; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany., Bryson S; CRUK Beatson Institute, Glasgow, UK., Warrander FC; CRUK Beatson Institute, Glasgow, UK., Erhard F; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany., Ade CP; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany., Baluapuri A; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany., Walz S; Comprehensive Cancer Center Mainfranken, Core Unit Bioinformatics, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany., Jackstadt R; CRUK Beatson Institute, Glasgow, UK., Ford C; CRUK Beatson Institute, Glasgow, UK., Vlachogiannis G; Division of Molecular Pathology, The Institute of Cancer Research, London, UK., Valeri N; Division of Molecular Pathology, The Institute of Cancer Research, London, UK.; Department of Medicine, The Royal Marsden NHS Trust, London, UK., Otto C; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany., Schülein-Völk C; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany., Maurus K; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany., Schmitz W; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany., Knight JRP; CRUK Beatson Institute, Glasgow, UK., Wolf E; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany., Strathdee D; CRUK Beatson Institute, Glasgow, UK., Schulze A; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany., Germer CT; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany., Rosenwald A; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany., Sansom OJ; CRUK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Eilers M; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany. martin.eilers@biozentrum.uni-wuerzburg.de.; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany. martin.eilers@biozentrum.uni-wuerzburg.de., Wiegering A; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany. wiegering_a@ukw.de.; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany. wiegering_a@ukw.de.; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany. wiegering_a@ukw.de.

Publikováno v: Nature cell biology [Nat Cell Biol] 2019 Nov; Vol. 21 (11), pp. 1413-1424. Date of Electronic Publication: 2019 Nov 04.

Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.

Autor: Wiegering A; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.; University Hospital Würzburg, Department of General, Visceral, Vascular and Pediatric Surgery, Würzburg, Germany., Uthe FW; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany., Jamieson T; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Ruoss Y; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany., Hüttenrauch M; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany., Küspert M; Department of Biochemistry, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany., Pfann C; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany., Nixon C; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Herold S; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany., Walz S; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University of Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany., Taranets L; Comprehensive Cancer Center Mainfranken, University of Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany., Germer CT; University Hospital Würzburg, Department of General, Visceral, Vascular and Pediatric Surgery, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University of Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany., Rosenwald A; Comprehensive Cancer Center Mainfranken, University of Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany.; Institute of Pathology, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany., Sansom OJ; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Eilers M; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University of Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany.

Publikováno v: Cancer discovery [Cancer Discov] 2015 Jul; Vol. 5 (7), pp. 768-781. Date of Electronic Publication: 2015 May 01.

CIP2A influences survival in colon cancer and is critical for maintaining Myc expression.

Autor: Wiegering A; Department of General, Visceral, Vascular and Paediatric Surgery (Department of Surgery I), University Hospital Wuerzburg, Wuerzburg, Germany ; Department of Biochemistry and Molecular Biology, University of Wuerzburg, Wuerzburg, Germany., Pfann C, Uthe FW, Otto C, Rycak L, Mäder U, Gasser M, Waaga-Gasser AM, Eilers M, Germer CT

Publikováno v: PloS one [PLoS One] 2013 Oct 01; Vol. 8 (10), pp. e75292. Date of Electronic Publication: 2013 Oct 01 (Print Publication: 2013).