Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ute Woehlbier"'
Autor:
Sebastián Oyarce-Pezoa, Guilherme Gischkow Rucatti, Francisco Muñoz-Carvajal, Nicole Sanhueza, Wileidy Gomez, Sandra Espinoza, Mario Leiva, Nicolás García, Daniela P. Ponce, Carol D. SanMartín, Diego Rojas-Rivera, Natalia Salvadores, Maria I. Behrens, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by protein accumulation in the brain as a main neuropathological hallmark. Among them, Aβ42 peptides tend to aggregate and create oligomers and plaques. M
Externí odkaz:
https://doaj.org/article/2ea3471a475747d3ac630b2c4a0a31ae
Autor:
Sergio Sanhueza, Mabel A. Vidal, Mauricio A. Hernandez, Mario E. Henriquez-Beltran, Camilo Cabrera, Romina Quiroga, Bárbara E. Antilef, Kevin P. Aguilar, Daniela A. Castillo, Faryd J. Llerena, Marco Fraga Figueroa, Mauricio Nazal, Eritson Castro, Paola Lagos, Alexa Moreno, Jaime J. Lastra, Jorge Gajardo, Pamela Garcés, Benilde Riffo, Jorge Buchert, Rocío Sanhueza, Valeska Ormazába, Pablo Saldivia, Cristian Vargas, Guillermo Nourdin, Elard Koch, Felipe A. Zuñiga, Liliana Lamperti, Paula Bustos, Enrique Guzmán-Gutiérrez, Claudio A. Tapia, Luciano Ferrada, Gustavo Cerda, Ute Woehlbier, Erick Riquelme, Maria-Isabel Yuseff, Braulio A. Muñoz Ramirez, Giovanna Lombardi, David De Gonzalo-Calvo, Carlos Salomon, Ricardo A. Verdugo, Luis A. Quiñones, Alicia Colombo, Maria I. Barría, Gonzalo Labarca, Estefania Nova-Lamperti
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionLong-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of previous comorbidities, however, th
Externí odkaz:
https://doaj.org/article/076cb30c114e41aa9df9c484ce295dec
Autor:
Sandra Espinoza, Felipe Grunenwald, Wileidy Gomez, Felipe García, Lorena Abarzúa-Catalan, Sebastián Oyarce-Pezoa, Maria Fernanda Hernandez, Bastián I. Cortés, Markus Uhrig, Daniela P. Ponce, Claudia Durán-Aniotz, Claudio Hetz, Carol D. SanMartín, Victor H. Cornejo, Fernando Ezquer, Valentina Parra, Maria Isabel Behrens, Patricio A. Manque, Diego Rojas-Rivera, René L. Vidal, Ute Woehlbier, Melissa Nassif
Publikováno v:
Cells, Vol 11, Iss 12, p 1860 (2022)
Alzheimer’s disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon is a well-established inhi
Externí odkaz:
https://doaj.org/article/2c0619b110c14ca2bc7f93cba197acc2
Autor:
Cristian A. Bergmann, Sebastian Beltran, Ana Maria Vega-Letter, Paola Murgas, Maria Fernanda Hernandez, Laura Gomez, Luis Labrador, Bastián I. Cortés, Cristian Poblete, Cristobal Quijada, Flavio Carrion, Ute Woehlbier, Patricio A. Manque
Publikováno v:
Cells, Vol 11, Iss 9, p 1503 (2022)
Mesenchymal stem cells (MSC) have emerged as a promising tool to treat inflammatory diseases, such as inflammatory bowel disease (IBD), due to their immunoregulatory properties. Frequently, IBD is modeled in mice by using dextran sulfate sodium (DSS)
Externí odkaz:
https://doaj.org/article/de383cfc8e13458d81d27fcb9b1e7fce
Autor:
Emiliano Vicencio, Sebastián Beltrán, Luis Labrador, Patricio Manque, Melissa Nassif, Ute Woehlbier
Publikováno v:
Cells, Vol 9, Iss 2, p 381 (2020)
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. Several cellular mechanis
Externí odkaz:
https://doaj.org/article/5a0b4c2bfdf543d893a2b59158e6f775
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons resulting in a progressive and irreversible muscular paralysis. Advances in large-scale genetics and genomics have revealed intr
Externí odkaz:
https://doaj.org/article/eafa8f3140af4e619ea0fd8a746463fa
Autor:
Valentina Castillo, Maritza Oñate, Ute Woehlbier, Pablo Rozas, Catherine Andreu, Danilo Medinas, Pamela Valdés, Fabiola Osorio, Gabriela Mercado, René L Vidal, Bredford Kerr, Felipe A Court, Claudio Hetz
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140200 (2015)
Externí odkaz:
https://doaj.org/article/06e1f92fe456413c960d4ddcb83ecfb7
Autor:
Valentina Castillo, Maritza Oñate, Ute Woehlbier, Pablo Rozas, Catherine Andreu, Danilo Medinas, Pamela Valdés, Fabiola Osorio, Gabriela Mercado, René L Vidal, Bredford Kerr, Felipe A Court, Claudio Hetz
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136620 (2015)
ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common neurodegenerative diseases d
Externí odkaz:
https://doaj.org/article/bbbea61673524001ad42eab302713e60
Autor:
Mauricio Torres, Luis Cartier, José Manuel Matamala, Nancy Hernández, Ute Woehlbier, Claudio Hetz
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36159 (2012)
Creutzfeldt-Jakob disease (CJD) is the most frequent human Prion-related disorder (PrD). The detection of 14-3-3 protein in the cerebrospinal fluid (CSF) is used as a molecular diagnostic criterion for patients clinically compatible with CJD. However
Externí odkaz:
https://doaj.org/article/c52904a202294d1e8ce4a9abb37c90be
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31030 (2012)
Herein, we report the biochemical and functional characterization of a novel Ca(2+)-activated nucleoside diphosphatase (apyrase), CApy, of the intracellular gut pathogen Cryptosporidium. The purified recombinant CApy protein displayed activity, subst
Externí odkaz:
https://doaj.org/article/f47db7831a2d4b44a2a879593c7a490b