Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ute Woehlbier"'
Autor:
Luis Labrador, Leonardo Rodriguez, Sebastián Beltran, Fernanda Hernandez, Laura Gomez, Patricia Ojeda, Cristian Bergmann, Melissa Calegaro-Nassif, Bredford Kerr, Danilo B. Medinas, Patricio Manque, Ute Woehlbier
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-13 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mutant superoxide dismutase 1 (SOD1) misfolding and aggregation have been linked to familial ALS, with the accumulation of
Externí odkaz:
https://doaj.org/article/38d0d472354c4eb99b8f8a8b8cb3237e
Autor:
Sebastián Oyarce-Pezoa, Guilherme Gischkow Rucatti, Francisco Muñoz-Carvajal, Nicole Sanhueza, Wileidy Gomez, Sandra Espinoza, Mario Leiva, Nicolás García, Daniela P. Ponce, Carol D. SanMartín, Diego Rojas-Rivera, Natalia Salvadores, Maria I. Behrens, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by protein accumulation in the brain as a main neuropathological hallmark. Among them, Aβ42 peptides tend to aggregate and create oligomers and plaques. M
Externí odkaz:
https://doaj.org/article/2ea3471a475747d3ac630b2c4a0a31ae
Autor:
Sergio Sanhueza, Mabel A. Vidal, Mauricio A. Hernandez, Mario E. Henriquez-Beltran, Camilo Cabrera, Romina Quiroga, Bárbara E. Antilef, Kevin P. Aguilar, Daniela A. Castillo, Faryd J. Llerena, Marco Fraga Figueroa, Mauricio Nazal, Eritson Castro, Paola Lagos, Alexa Moreno, Jaime J. Lastra, Jorge Gajardo, Pamela Garcés, Benilde Riffo, Jorge Buchert, Rocío Sanhueza, Valeska Ormazába, Pablo Saldivia, Cristian Vargas, Guillermo Nourdin, Elard Koch, Felipe A. Zuñiga, Liliana Lamperti, Paula Bustos, Enrique Guzmán-Gutiérrez, Claudio A. Tapia, Luciano Ferrada, Gustavo Cerda, Ute Woehlbier, Erick Riquelme, Maria-Isabel Yuseff, Braulio A. Muñoz Ramirez, Giovanna Lombardi, David De Gonzalo-Calvo, Carlos Salomon, Ricardo A. Verdugo, Luis A. Quiñones, Alicia Colombo, Maria I. Barría, Gonzalo Labarca, Estefania Nova-Lamperti
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionLong-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of previous comorbidities, however, th
Externí odkaz:
https://doaj.org/article/076cb30c114e41aa9df9c484ce295dec
Autor:
Sandra Espinoza, Felipe Grunenwald, Wileidy Gomez, Felipe García, Lorena Abarzúa-Catalan, Sebastián Oyarce-Pezoa, Maria Fernanda Hernandez, Bastián I. Cortés, Markus Uhrig, Daniela P. Ponce, Claudia Durán-Aniotz, Claudio Hetz, Carol D. SanMartín, Victor H. Cornejo, Fernando Ezquer, Valentina Parra, Maria Isabel Behrens, Patricio A. Manque, Diego Rojas-Rivera, René L. Vidal, Ute Woehlbier, Melissa Nassif
Publikováno v:
Cells, Vol 11, Iss 12, p 1860 (2022)
Alzheimer’s disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon is a well-established inhi
Externí odkaz:
https://doaj.org/article/2c0619b110c14ca2bc7f93cba197acc2
Autor:
Cristian A. Bergmann, Sebastian Beltran, Ana Maria Vega-Letter, Paola Murgas, Maria Fernanda Hernandez, Laura Gomez, Luis Labrador, Bastián I. Cortés, Cristian Poblete, Cristobal Quijada, Flavio Carrion, Ute Woehlbier, Patricio A. Manque
Publikováno v:
Cells, Vol 11, Iss 9, p 1503 (2022)
Mesenchymal stem cells (MSC) have emerged as a promising tool to treat inflammatory diseases, such as inflammatory bowel disease (IBD), due to their immunoregulatory properties. Frequently, IBD is modeled in mice by using dextran sulfate sodium (DSS)
Externí odkaz:
https://doaj.org/article/de383cfc8e13458d81d27fcb9b1e7fce
Autor:
Emiliano Vicencio, Sebastián Beltrán, Luis Labrador, Patricio Manque, Melissa Nassif, Ute Woehlbier
Publikováno v:
Cells, Vol 9, Iss 2, p 381 (2020)
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. Several cellular mechanis
Externí odkaz:
https://doaj.org/article/5a0b4c2bfdf543d893a2b59158e6f775
Autor:
Patricio Manque, Nohela B Arévalo, Maria I. Behrens, Ute Woehlbier, Carol D. SanMartín, Esteban Leyton, Paola Murgas, Claudia Duran-Aniotz, Bastián I Cortés, Sandra Espinoza, Wileidy Gomez, Diego Matus, José Matías Benitez, Melissa Nassif, Claudio Hetz
Publikováno v:
Journal of Alzheimer's Disease. 82:S163-S178
Background: Disturbances in the autophagy/endolysosomal systems are proposed as early signatures of Alzheimer’s disease (AD). However, few studies are available concerning autophagy gene expression in AD patients. Objective: To explore the differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b5e1b155b19cfd6abb30af23427f8f
https://doi.org/10.3233/jad-201264
https://doi.org/10.3233/jad-201264
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons resulting in a progressive and irreversible muscular paralysis. Advances in large-scale genetics and genomics have revealed intr
Externí odkaz:
https://doaj.org/article/eafa8f3140af4e619ea0fd8a746463fa
Autor:
Danilo Bilches Medinas, Sajid Malik, Esra Yıldız‐Bölükbaşı, Janina Borgonovo, Mirva J Saaranen, Hery Urra, Eduardo Pulgar, Muhammad Afzal, Darwin Contreras, Madison T Wright, Felipe Bodaleo, Gabriel Quiroz, Pablo Rozas, Sara Mumtaz, Rodrigo Díaz, Carlos Rozas, Felipe Cabral‐Miranda, Ricardo Piña, Vicente Valenzuela, Ozgun Uyan, Christopher Reardon, Ute Woehlbier, Robert H Brown, Miguel Sena‐Esteves, Christian Gonzalez‐Billault, Bernardo Morales, Lars Plate, Lloyd W Ruddock, Miguel L Concha, Claudio Hetz, Aslıhan Tolun
Publikováno v:
EMBO J
Recessive gene mutations underlie many developmental disorders and often lead to disabling neurological problems. Here, we report identification of a homozygous c.170G>A (p.Cys57Tyr or C57Y) mutation in the gene coding for protein disulfide isomerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6613e8538ac476726f6e672a582c42a8
https://europepmc.org/articles/PMC8762563/
https://europepmc.org/articles/PMC8762563/
Autor:
Valentina Castillo, Maritza Oñate, Ute Woehlbier, Pablo Rozas, Catherine Andreu, Danilo Medinas, Pamela Valdés, Fabiola Osorio, Gabriela Mercado, René L Vidal, Bredford Kerr, Felipe A Court, Claudio Hetz
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140200 (2015)
Externí odkaz:
https://doaj.org/article/06e1f92fe456413c960d4ddcb83ecfb7