Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Ute Modlich"'
Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements
Autor:
Federica Raimondi, Kah Mun Siow, Dominik Wrona, Carla Fuster-García, Oleksandr Pastukhov, Michael Schmitz, Katja Bargsten, Lucas Kissling, Daan C. Swarts, Geoffroy Andrieux, Toni Cathomen, Ute Modlich, Martin Jinek, Ulrich Siler, Janine Reichenbach
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract CRISPR-based genome editing of pseudogene-associated disorders, such as p47 phox -deficient chronic granulomatous disease (p47 CGD), is challenged by chromosomal rearrangements due to presence of multiple targets. We report that interactions
Externí odkaz:
https://doaj.org/article/93b02712c21d4f31ac658ae71b0f19f4
Autor:
Tanja Hirch, Nadine Brander, Franziska Schenk, Simon J. Pöllmann, Janine Reichenbach, Ralf Schubert, Ute Modlich
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Ataxia telangiectasia is a monogenetic disorder caused by mutations in the ATM gene. Its encoded protein kinase ATM plays a fundamental role in DNA repair of double strand breaks (DSBs). Impaired function of this kinase leads to a multisyste
Externí odkaz:
https://doaj.org/article/0fa81c50e414411d8c70f75fba245208
Autor:
Vanessa M.A. Woods, Lisette J. Latorre-Rey, Franziska Schenk, Marcel G.E. Rommel, Thomas Moritz, Ute Modlich
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 774-786 (2022)
Platelets are anucleate blood cells that are shed from megakaryocytes (MKs) into the bloodstream to maintain hemostasis and promote wound healing after vascular injury. To carry out their functions, platelets become activated and release bioactive su
Externí odkaz:
https://doaj.org/article/426d508b45ff45f785edcba6b6c9e530
Autor:
Marcel G.E. Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Csaba Miskey, Lacramioara Botezatu, Yvonne Krebs, Iris M. Voelker, Kevin Wittwer, Tim Holland-Letz, Zoltán Ivics, Veronika von Messling, Marieke A.G. Essers, Michael D. Milsom, Christian K. Pfaller, Ute Modlich
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111447- (2022)
Summary: Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and pr
Externí odkaz:
https://doaj.org/article/4f2b90b0b8ec49f9816a17097e7b27e9
Autor:
Katharina Cullmann, Magdalena Jahn, Markus Spindler, Franziska Schenk, Georgi Manukjan, Adele Mucci, Doris Steinemann, Klaus Boller, Harald Schulze, Markus Bender, Thomas Moritz, Ute Modlich
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 1, Pp 111-124 (2021)
Abstract Background Platelets are small anucleate cells that circulate in the blood in a resting state but can be activated by external cues. In case of need, platelets from blood donors can be transfused. As an alternative source, platelets can be p
Externí odkaz:
https://doaj.org/article/58dd3eea25984663a92a4d665ab1d1f6
Autor:
Stephan Müller, Tobias Bexte, Veronika Gebel, Franziska Kalensee, Eva Stolzenberg, Jessica Hartmann, Ulrike Koehl, Axel Schambach, Winfried S. Wels, Ute Modlich, Evelyn Ullrich
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Autologous chimeric antigen receptor-modified (CAR) T cells with specificity for CD19 showed potent antitumor efficacy in clinical trials against relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL). Contrary to T cells, natural killer
Externí odkaz:
https://doaj.org/article/d8dae0285dea4bba84619752c586d5b2
Autor:
Anett Pfeiffer, Frederic B Thalheimer, Sylvia Hartmann, Annika M Frank, Ruben R Bender, Simon Danisch, Caroline Costa, Winfried S Wels, Ute Modlich, Renata Stripecke, Els Verhoeyen, Christian J Buchholz
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-11 (2018)
Abstract Chimeric antigen receptor (CAR) T cells brought substantial benefit to patients with B‐cell malignancies. Notwithstanding, CAR T‐cell manufacturing requires complex procedures impeding the broad supply chain. Here, we provide evidence th
Externí odkaz:
https://doaj.org/article/0d3a5818f8be4f4293451029dc69af29
Autor:
Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Judith M.M. van Eeuwijk, Paquita Nurden, Simon Stritt, Tobias Heib, Katja Aurbach, Oguzhan Angay, Deya Cherpokova, Niels Heinz, Ayesha A. Baig, Maximilian G. Gorelashvili, Frank Gerner, Katrin G. Heinze, Jerry Ware, Georg Krohne, Zaverio M. Ruggeri, Alan T. Nurden, Harald Schulze, Ute Modlich, Irina Pleines, Cord Brakebusch, Bernhard Nieswandt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Düttinget al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting
Externí odkaz:
https://doaj.org/article/9a41c7db2ef649429ea7c2db2ddf72fe
Autor:
Sara El Ashkar, Dominique Van Looveren, Franziska Schenk, Lenard S. Vranckx, Jonas Demeulemeester, Jan De Rijck, Zeger Debyser, Ute Modlich, Rik Gijsbers
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 231-245 (2017)
Retroviral vectors have shown their curative potential in clinical trials correcting monogenetic disorders. However, therapeutic benefits were compromised due to vector-induced dysregulation of cellular genes and leukemia development in a subset of p
Externí odkaz:
https://doaj.org/article/efc62190fa804a3383b84d8e992681cc
Autor:
Ruth Duecker, Patrick C. Baer, Aileen Buecker, Sabine Huenecke, Lisa-Marie Pfeffermann, Ute Modlich, Shahrzad Bakhtiar, Peter Bader, Stefan Zielen, Ralf Schubert
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Ataxia-telangiectasia (A-T) is a multisystem disorder with progressive cerebellar ataxia, immunodeficiency, chromosomal instability, and increased cancer susceptibility. Cellular immunodeficiency is based on naïve CD4+ and CD8+ T-cell ly
Externí odkaz:
https://doaj.org/article/e8754e915039445e99bd174d0002e63f