Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ute Mettal"'
Functional in vitro and in vivo analysis of biosynthetic genes by heterologous expression in E. coli
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102531- (2023)
Summary: Biosynthetic gene clusters of natural products often harbor genes of unknown function, which are difficult to characterize. Here, we present a protocol for the functional analysis in vitro and in vivo of these biosynthetic genes by heterolog
Externí odkaz:
https://doaj.org/article/51124c51be8c44bdb94e5941c61d5a2f
Autor:
Michael Marner, Laura Kolberg, Julia Horst, Nils Böhringer, Johannes Hübner, I Dewa M. Kresna, Yang Liu, Ute Mettal, Lei Wang, Melanie Meyer-Bühn, Sanja Mihajlovic, Matthias Kappler, Till F. Schäberle, Ulrich von Both
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The emergence and spread of antimicrobial resistance (AMR) in Gram-negative pathogens, such as carbapenem-resistant Pseudomonas aeruginosa, pose an increasing threat to health care. Patients with immunodeficiencies or chronic pulmonary disea
Externí odkaz:
https://doaj.org/article/33dc2de94e8a4e6fb2ddc2de32f8329d
Autor:
Jonas Buck, Dennis Mueller, Ute Mettal, Miriam Ackermann, Hiu Man Grisch-Chan, Beat Thöny, Andreas Zumbuehl, Jörg Huwyler, Dominik Witzigmann
Publikováno v:
ACS Omega, Vol 5, Iss 38, Pp 24724-24732 (2020)
Externí odkaz:
https://doaj.org/article/78406cbe61a24233baa11011570fcf0f
Autor:
Nils Böhringer, Robert Green, Yang Liu, Ute Mettal, Michael Marner, Seyed Majed Modaresi, Roman P. Jakob, Zerlina G. Wuisan, Timm Maier, Akira Iinishi, Sebastian Hiller, Kim Lewis, Till F. Schäberle
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT There is great need for therapeutics against multidrug-resistant, Gram-negative bacterial pathogens. Recently, darobactin A, a novel bicyclic heptapeptide that selectively kills Gram-negative bacteria by targeting the outer membrane protein
Externí odkaz:
https://doaj.org/article/1d9de47591604c918f32d1bde797defd
Publikováno v:
Marine Drugs, Vol 20, Iss 10, p 620 (2022)
Marine flavobacterium Tenacibaculum discolor sv11 has been proven to be a promising producer of bioactive nitrogen-containing heterocycles. A chemical investigation of T. discolor sv11 revealed seven new heterocycles, including the six new imidazoliu
Externí odkaz:
https://doaj.org/article/9f84a23624ea49a8a06fafbcbde7a57c
Autor:
Aninditia Sabdaningsih, Yang Liu, Ute Mettal, John Heep, Riyanti, Lei Wang, Olvi Cristianawati, Handung Nuryadi, Mada Triandala Sibero, Michael Marner, Ocky Karna Radjasa, Agus Sabdono, Agus Trianto, Till F. Schäberle
Publikováno v:
Marine Drugs, Vol 18, Iss 4, p 227 (2020)
Sponge-associated fungi are attractive targets for the isolation of bioactive natural products with different pharmaceutical purposes. In this investigation, 20 fungi were isolated from 10 different sponge specimens. One isolate, the fungus Penicilli
Externí odkaz:
https://doaj.org/article/e764a612cba04a57a442b6cbc9099683
Autor:
Bert Müller, Sofiya Matviykiv, Gabriela Gerganova, Tamás Mészáros, Gergely Tibor Kozma, Ute Mettal, Frederik Neuhaus, Takashi Ishikawa, János Szebeni, Andreas Zumbuehl
Publikováno v:
Precision Nanomedicine, Vol 1, Iss 1 (2018)
Liposomal drug delivery systems can protect pharmaceutical substances and control their release. Systemic administration of liposomes, however, often activate the innate immune system, resulting in hypersensitivity reactions. These pseudo-allergic re
Externí odkaz:
https://doaj.org/article/9d8762b534e7467987f7a407c38bc1f1
Autor:
Walter Balansa, Ute Mettal, Zerlina G. Wuisan, Anuchit Plubrukarn, Frans G. Ijong, Yang Liu, Till F. Schäberle
Publikováno v:
Marine Drugs, Vol 17, Iss 3, p 158 (2019)
Sponges are a well-known bioresource for bioactive compounds. In this study, antibacterial activity-guided fractionation of the extract from an Indonesian marine Dactylospongia elegans sponge led to the discovery of four merosesquiterpenoids, namely,
Externí odkaz:
https://doaj.org/article/df7d43e9233e4d4898deb98e25e80aac
Publikováno v:
Polymers, Vol 10, Iss 1, p 54 (2018)
Giant vesicles (GVs) are widely-used model systems for biological membranes. The formulation of these vesicles, however, can be problematic and artifacts, such as degraded molecules or left-over oil, may be present in the final liposomes. The rapid f
Externí odkaz:
https://doaj.org/article/2e39654b42a64f1f87b5df9437429420
Autor:
I Dewa M. Kresna, Zerlina G. Wuisan, Jean-Marie Pohl, Ute Mettal, Virginia Linares Otoya, Martin Gand, Michael Marner, Luis Linares Otoya, Nils Böhringer, Andreas Vilcinskas, Till F. Schäberle
Publikováno v:
Journal of Natural Products. 85:888-898
The azinothricin family comprises several cyclic hexadepsipeptides with diverse pharmacological bioactivities, including antimicrobial, antitumoral, and apoptosis induction. In this work, using a genome mining approach, a biosynthetic gene cluster en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4f549b812272c31c8739520a9ac8eb
https://doi.org/10.1021/acs.jnatprod.1c01018
https://doi.org/10.1021/acs.jnatprod.1c01018