Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ute Mühlhausen"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 52:13-22
In psychiatric disorders such as anxiety, depression and schizophrenia, 5-HT2A receptors play an important role. In order to investigate them in vivo there is an increasing interest in selective and high-affinity radioligands for receptor binding stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5b082e47e1108cde90c5d430028c9d0
https://doi.org/10.1002/jlcr.1565
https://doi.org/10.1002/jlcr.1565
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 52:6-12
In some psychiatric disorders 5-HT2A receptors play an important role. In order to investigate those in vivo there is an increasing interest in obtaining a metabolically stable, subtype selective and high affinity radioligand for receptor binding stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cae2e694521bf03819822e440cd051d
https://doi.org/10.1002/jlcr.1563
https://doi.org/10.1002/jlcr.1563
Autor:
Ralf Schirrmacher, Markus Christmann, Bernd Kaina, Andrea Piee-Staffa, Frank Rösch, Ute Mühlhausen, Regine Garcia Boy
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 311:585-593
The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is an important suicide enzyme involved in the defense against O(6)-alkylating mutagens. It also plays a role in the resistance of tumors to anticancer drugs targeting the O(6)-po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b8558a5e42a70e87cca6cd220f4e29
https://doi.org/10.1124/jpet.104.071316
https://doi.org/10.1124/jpet.104.071316
Autor:
B Wängler, Bernd Kaina, Gerd Nagel, Frank Rösch, Esther Schirrmacher, Jost Reinhard, Manfred Wießler, Ute Mühlhausen, Markus Piel, Ralf Schirrmacher
Publikováno v:
Tetrahedron Letters. 43:6301-6304
The synthesis of the novel glucose conjugated O6-methylguanine-DNA methyltransferase (MGMT) inhibitor 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-α- d -glucosyl)-purine is reported. This compound might serve as a radiotracer for the dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2817779ca6fa81d52bcc7f9ebab00115
https://doi.org/10.1016/s0040-4039(02)01394-1
https://doi.org/10.1016/s0040-4039(02)01394-1
Autor:
Dorde Komljenovic, Karin Leotta, Ute Mühlhausen, Maren Bretschi, Wolfhard Semmler, Tobias Bäuerle, Michael Eisenhut
Publikováno v:
Contrast mediamolecular imaging. 6(6)
The aim of this study was the evaluation of (68)Ga-DOTA-E-[c(RGDfK)](2) as a novel PET tracer to image αvβ3 and αvβ5 integrins. For this purpose, DOTA-E-[c(RGDfK)](2) was labeled with (68)Ga, which was obtained from a (68)Ge/(68)Ga generator, pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2915f8f096677a49b06f010cfabc7d0b
https://pubmed.ncbi.nlm.nih.gov/22162137
https://pubmed.ncbi.nlm.nih.gov/22162137
Publikováno v:
Nuclear medicine and biology. 37(5)
In psychiatric disorders, 5-HT 2A receptors play an important role. In order to study these receptors in vivo by positron emission tomography (PET), there is an increasing interest for subtype selective and high affinity radioligands. Up to now, no o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827810c423559e5f856fbb6ced99080d
https://pubmed.ncbi.nlm.nih.gov/20610165
https://pubmed.ncbi.nlm.nih.gov/20610165
Autor:
Frank Rösch, Bernd Kaina, Ute Mühlhausen, Manuela Briegert, Andrea Piee-Staffa, Bernd Dr. Lecher, Ralf Schirrmacher, Markus Piel
Publikováno v:
Journal of medicinal chemistry. 49(1)
O 6 -Substituted guanine derivatives are powerful agents used for tumor cell sensitization by inhibition of the DNA repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT). To provide targeted accumulation of MGMT inhibitors in tumor tissue as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1de31e9bce982ae32c32992dd43d2ba
https://pubmed.ncbi.nlm.nih.gov/16392811
https://pubmed.ncbi.nlm.nih.gov/16392811