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Akademický článek

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.

Autor: Paola Di Meglio, Antonella Di Cesare, Ute Laggner, Chung-Ching Chu, Luca Napolitano, Federica Villanova, Isabella Tosi, Francesca Capon, Richard C Trembath, Ketty Peris, Frank O Nestle

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e17160 (2011)

IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankyl

Externí odkaz: https://doaj.org/article/65d3ec30fdb44d5cb1064f1049b3c293

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MALT lymphoma arising on a background of reactive pulmonary lymphoid hyperplasia in a patient with systemic lupus erythematosus

Autor: Reena Khiroya, Andrew Wotherspoon, Ute Laggner, Andrew G. Nicholson, Sujal R. Desai

Publikováno v: Histopathology. 72(4)

Interstitial lung diseases are not infrequently complicated by development of malignancies and whilst most cases are carcinomas, rare cases of lymphoma have been reported,(1 2) these being diffuse large B-cell lymphomas and often associated with conn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97aaacba6e1152626ac238e95ddf701
https://pubmed.ncbi.nlm.nih.gov/28945277

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Expression of PD-L1 correlates with pleomorphic morphology and histological patterns of non-small-cell lung carcinomas

Autor: James Croud, Olivia McKinney, Alexandra Rice, Francois Ng Kee Kwong, Andrew G. Nicholson, Ute Laggner

Publikováno v: Histopathology. 72(6)

AIMS As immunomodulatory therapy is being integrated into treatment regimens for non-small-cell lung carcinoma, we aimed to prospectively collect data on the immunohistochemical profile of tumours assessed in our institution and to correlate this wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6e41137f3add165e9297e2c957f6da
https://pubmed.ncbi.nlm.nih.gov/29323731

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α1β1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis

Autor: Onur Boyman, Ute Laggner, Antonin de Fougerolles, Curdin Conrad, Victor E. Kotelianski, Adrian Tun-Kyi, Frank O. Nestle, Humphrey Gardner, Giulia Tonel

Publikováno v: Nature Medicine. 13:836-842

Psoriasis is a common T cell-mediated autoimmune inflammatory disease. We show that blocking the interaction of alpha1beta1 integrin (VLA-1) with collagen prevented accumulation of epidermal T cells and immunopathology of psoriasis. Alpha1beta1 integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c94c1975431cea3a02013013a63cc8
https://doi.org/10.1038/nm1605

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Immunohistochemical Analysis of INI1 Protein in Malignant Pediatric CNS Tumors: Lack of INI1 in Atypical Teratoid/Rhabdoid Tumors and in a Fraction of Primitive Neuroectodermal Tumors without Rhabdoid Phenotype

Autor: Irene Slavc, Herbert Budka, Inge M. Ambros, Thomas Czech, Ute Laggner, Peter F. Ambros, Christine Haberler, Johannes A. Hainfellner

Publikováno v: American Journal of Surgical Pathology. 30:1462-1468

Immunohistochemical lack of nuclear INI1 protein expression has been recently described as characteristic finding in atypical teratoid/rhabdoid tumors (AT/RTs), and has been suggested as useful marker to distinguish AT/RTs from other malignant pediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934f02df7cd8b544d4ea8f2f15b466d0
https://doi.org/10.1097/01.pas.0000213329.71745.ef

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Inflammatory response in human tick-borne encephalitis: analysis of postmortem brain tissue

Autor: Ferenc Garzuly, Heidemarie Holzmann, Ute Laggner, Franz X. Heinz, Herbert Budka, Ellen Gelpi, Matthias Preusser

Publikováno v: Journal of NeuroVirology. 12:322-327

In Central European tick-borne encephalitis (TBE) mechanisms of tissue destruction are poorly understood. To evaluate the contribution of immunological mechanisms to tissue injury, the authors immunohistochemically analyzed paraffin-embedded autoptic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd307d64a8b02898aef9a1ca8ecc0e2
https://doi.org/10.1080/13550280600848746

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Comparative analysis of NeuN immunoreactivity in primary brain tumours: conclusions for rational use in diagnostic histopathology

Autor: Herbert Budka, Matthias Preusser, Christine Haberler, J. A. Hainfellner, Harald Heinzl, Ute Laggner

Publikováno v: Histopathology. 48:438-444

Aims : NeuN is considered to be a marker of neuronal differentiation in brain tumours. Our aim was to perform, for the first time, a systematic and comparative analysis of NeuN expression in all major brain tumour subtypes to provide guidance for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead36f2a107473c5d9ae76bb7032caa0
https://doi.org/10.1111/j.1365-2559.2006.02359.x

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Identification of a novel pro-inflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis

Autor: Christian Hundhausen, Ute Laggner, Adrian Hayday, Catherine H. Smith, Niwa Ali, Brian J. Nickoloff, Katie E. Lacy, Gayathri K. Perera, Frank O. Nestle, Paola Di Meglio

γδ T cells mediate rapid tissue responses in murine skin and participate in cutaneous immune regulation including protection against cancer. The role of human γδ cells in cutaneous homeostasis and pathology is characterized poorly. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1612ef9def2b5015a6dd0335c3e81cfa
https://europepmc.org/articles/PMC3187621/

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