Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ute Hecker"'
Autor:
Werner Siegmund, Stefanie Igelbrink, Ute Hecker, Ingolf Cascorbi, Bernd Terhaag, Sierk Haenisch, Danilo Wegner, Christiane Modess, Annika Bernsdorf, Thomas Giessmann
Publikováno v:
British Journal of Clinical Pharmacology. 61:440-450
Aims To evaluate whether simvastatin influences (i) the intestinal expression of P-glycoprotein (P-gp) and MRP2, and (ii) the disposition of the β1-selective blocker talinolol, a substrate of these transporter proteins. Methods The disposition of ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a7abf152e6a3fc3a1b60d623f140a2
https://doi.org/10.1111/j.1365-2125.2006.02599.x
https://doi.org/10.1111/j.1365-2125.2006.02599.x
Autor:
Werner Siegmund, Ute Hecker, Rolf Warzok, Danilo Wegner, Peter Dazert, Markus Grube, Eike Schroeder, Thomas Giessmann, K. May, Zschiesche M, Heyo K. Kroemer, Ingolf Cascorbi, Christiane Modess
Publikováno v:
Clinical Pharmacology & Therapeutics. 76:192-200
Background and methods The antiepileptic drug carbamazepine is known to be an inducer of cytochrome P450 (CYP) 3A4 after binding to the nuclear pregnane X receptor. To evaluate whether it also regulates the multidrug transporter proteins P-glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52366fb86f530f473cdf466c94c3260
https://doi.org/10.1016/j.clpt.2004.04.011
https://doi.org/10.1016/j.clpt.2004.04.011
Publikováno v:
Clinical Toxicology. 46:694-696
Anticholinesterase compounds like organophosphorous and carbamates account for the majority of poisonings by the insecticides class agents. While the toxicokinetic depends on the extent of exposure and also on the chemical structure of the agent, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70cf63192094d0ac4179fffdf7aee36
https://doi.org/10.1080/15563650701476961
https://doi.org/10.1080/15563650701476961
Autor:
Annika, Bernsdorf, Thomas, Giessmann, Christiane, Modess, Danilo, Wegner, Stefanie, Igelbrink, Ute, Hecker, Sierk, Haenisch, Ingolf, Cascorbi, Bernd, Terhaag, Werner, Siegmund
Publikováno v:
British journal of clinical pharmacology. 61(4)
To evaluate whether simvastatin influences (i) the intestinal expression of P-glycoprotein (P-gp) and MRP2, and (ii) the disposition of the beta(1)-selective blocker talinolol, a substrate of these transporter proteins.The disposition of talinolol af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb8ec6408320f773ac8149e08abca624
https://pubmed.ncbi.nlm.nih.gov/16542205
https://pubmed.ncbi.nlm.nih.gov/16542205
Autor:
Werner Siegmund, Ute Hecker, Thomas Giessmann, Peter Dazert, Georg P. Engel, Werner Weitschies, Zschiesche M, Rolf Warzok, Heyo K. Kroemer, Ingolf Cascorbi, Christiane Modess, Christiane Kunert-Keil
Publikováno v:
Clinical pharmacology and therapeutics. 75(3)
Background Clinical trials have indicated that the combined β- and α-adrenergic receptor blocker carvedilol improves the survival rate in patients with advanced chronic heart failure. The objective of our study was the identification and quantifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b458b39663a12134ccd007df19071a
https://pubmed.ncbi.nlm.nih.gov/15900290
https://pubmed.ncbi.nlm.nih.gov/15900290
Autor:
Heyo K. Kroemer, Andrea Paneitz, Bernhard Sperker, Stephan Altmannsberger, Ingolf Cascorbi, Bernd Terhaag, Rolf Warzok, Zschiesche M, Eike Schroeder, Wieland Meng, G. Franke, Werner Siegmund, Ute Hecker
Publikováno v:
Clinical pharmacology and therapeutics. 72(3)
Objective Thyroid function alters the pharmacokinetics of many drugs; one example is the cardiac glycoside digoxin. Because digoxin disposition is affected by intestinal expression of P-glycoprotein, we hypothesized that thyroid hormones may regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42638b7ff63bace03fd4b470c078627b
https://pubmed.ncbi.nlm.nih.gov/12235446
https://pubmed.ncbi.nlm.nih.gov/12235446
Autor:
Harald Schramm, Bernhard Leibl, Karsten Ridwelski, Peter Scholz, Karl H. Link, Kati Ott, Ernst D Kreuser, Jürgen H Vogt, Jörn Sträter, D. Behnke, Christoph Schlichting, Sucan Polat, Klaus-Ullrich Zerbian, Hans G. Beger, E. Kettner, Inga Galuba, Marko Kornmann, Peter Häusler, Ute Hecker, Wolfgang Schwabe, Wolfram Baumann, Frank Schütze
Publikováno v:
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 6(3)
Patients with International Union Against Cancer (UICC) stage IIb and III colon cancer and stage II and III rectal cancer may receive adjuvant chemotherapy with 5-fluorouracil (5-FU). High levels of thymidylate synthase (TS) and dihydropyrimidine deh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73581cbf7f41303a99c258fa4e200c13
https://pubmed.ncbi.nlm.nih.gov/12022983
https://pubmed.ncbi.nlm.nih.gov/12022983
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:P34-P34
BACKGROUND The human UDP-glucuronosyltransferase 1A1 (UGT1A1) is a major phase-II drug metabolizing enzyme, catalyzing conjugation of e.g. bilirubin with glucuronic acid. It is inducible by rifampicin and is subject of hereditary variability due to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659064f1f7a6649eaa35734c27c3691a
https://doi.org/10.1016/j.clpt.2005.12.123
https://doi.org/10.1016/j.clpt.2005.12.123
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