Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ute Frede"'
Autor:
Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anaïs F. Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N. Robinson, Christian Hagemeier, Michael Weber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to ger
Externí odkaz:
https://doaj.org/article/f118f417497a4386a18456d4d7889a0a
Autor:
Philippe Hammann, Hala Al Adhami, Gonzalo Alvarez, Matthias Truss, Sarah Kottnik, Christian Hagemeier, Johana Chicher, Judith Vallet, Anaïs F. Bardet, Jochen Hecht, Ute Frede, Thomas Dahlet, Michael Weber, Michael Dumas, Uschi Luz, Ghislain Auclair, Peter Hansen, Peter N. Robinson
Publikováno v:
Nature Communications
Nature Communications, 2021, 12, pp.3582. ⟨10.1038/s41467-021-23596-w⟩
Nature Communications, Nature Publishing Group, 2021, 12, pp.3582. ⟨10.1038/s41467-021-23596-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 2021, 12, pp.3582. ⟨10.1038/s41467-021-23596-w⟩
Nature Communications, Nature Publishing Group, 2021, 12, pp.3582. ⟨10.1038/s41467-021-23596-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here, we demonstrate that the transcription factor E2F6, a membe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ab6abc4ce0075028f98d18c18beb4e
https://hal.science/hal-03380281/file/Dahlet_NatComm_2021.pdf
https://hal.science/hal-03380281/file/Dahlet_NatComm_2021.pdf
Autor:
Christian Hagemeier, Axel Scholz, Ralf-Jürgen Kuban, Carmen Birchmeier, Michael Pohlers, Bettina Hoffmann, Matthias Truss, Markus Morkel, Michael Strehle, Ute Frede
Publikováno v:
Current Biology. 15:1051-1057
E2F transcription factors play a pivotal role in the regulation of cellular proliferation and can be subdivided into activating and repressing family members [1]. Like other E2Fs, E2F6 binds to E2F consensus sites, but in contrast to E2F1-5, it lacks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a21d3cae7e2712ab89b4a35fe61c69b
https://doi.org/10.1016/j.cub.2005.04.060
https://doi.org/10.1016/j.cub.2005.04.060
Autor:
Matthias W. Hentze, Niels H. Gehring, Margit Pförsich, Gabriele Neu-Yilik, Ute Frede, Sven Danckwardt, Andreas E. Kulozik, Patrick Hundsdoerfer
Publikováno v:
Blood. 104:428-435
The functional analysis of the common prothrombin 20210 G>A(F2 20210*A) mutation has recently revealed gain of function of 3′end processing as a novel genetic mechanism predisposing to human disease. We now show that the physiologic G at the cleava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294937a92d7b3b545f70f8aba66bdb15
https://doi.org/10.1182/blood-2003-08-2894
https://doi.org/10.1182/blood-2003-08-2894
Autor:
Rolf Thermann, Matthias W. Hentze, Ute Frede, Andreas E. Kulozik, Gabriele Neu-Yilik, Sven Danckwardt
Publikováno v:
Blood. 99:1811-1816
Nonsense-mediated mRNA decay (NMD) represents a phylogenetically widely conserved splicing- and translation-dependent mechanism that eliminates transcripts with premature translation stop codons and suppresses the accumulation of C-terminally truncat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0925d31371fa42815532f773aa885b04
https://doi.org/10.1182/blood.v99.5.1811
https://doi.org/10.1182/blood.v99.5.1811
Autor:
Christian Hagemeier, Livius Penter, Thomas Carell, Matthias Truss, Benjamin Hackner, Bert Maier, Ute Frede
Publikováno v:
Targeted oncology. 10(4)
After extensive research on radiochemotherapy, 5-year survival rates of children with high risk neuroblastoma still do not exceed 50%, owing to adverse side-effects exemplified by doxorubicin-induced cardiomyopathy. A promising new approach is the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ed790fee082af1682119c9d4b12500
https://pubmed.ncbi.nlm.nih.gov/25559288
https://pubmed.ncbi.nlm.nih.gov/25559288
Autor:
Barbara Vetter, Matthias W. Hentze, Andreas E. Kulozik, Niels H. Gehring, Gabriele Neu-Yilik, Ute Frede, Patrick Hundsdoerfer
Publikováno v:
Nature Genetics. 28:389-392
The G-->A mutation at position 20210 of the prothrombin or coagulation factor II gene (F2) represents a common genetic risk factor for the occurrence of thromboembolic events. This mutation affects the 3'-terminal nucleotide of the 3' untranslated re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef632698f6b17d2fa4ad828db0015ad6
https://doi.org/10.1038/ng578
https://doi.org/10.1038/ng578
Autor:
Matthias W. Hentze, Andrea Deters, Kristina Wehr, Christian Hagemeier, Gabriele Neu-Yilik, Andreas E. Kulozik, Ute Frede, Rolf Thermann
Publikováno v:
The EMBO Journal. 17:3484-3494
Premature translation termination codons resulting from nonsense or frameshift mutations are common causes of genetic disorders. Complications arising from the synthesis of C-terminally truncated polypeptides can be avoided by 'nonsense-mediated deca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d3b67aa670a861dae3903109504e2c
https://doi.org/10.1093/emboj/17.12.3484
https://doi.org/10.1093/emboj/17.12.3484
Autor:
Gabriele Neu-Yilik, Ute Frede, Andreas E. Kulozik, Matthias W. Hentze, Niels H. Gehring, Rolf Thermann
Premature translation termination codons are common causes of genetic disorders. mRNAs with such mutations are degraded by a surveillance mechanism termed nonsense-mediated decay (NMD), which represents a phylogenetically widely conserved post-transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f8f021e0fa9997d2eb9ca7dc4c6aac
https://europepmc.org/articles/PMC133467/
https://europepmc.org/articles/PMC133467/