Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Ute A, Hellmich"'
Autor:
Èric Catalina-Hernández, Mario López-Martín, David Masnou-Sánchez, Marco Martins, Victor A. Lorenz-Fonfria, Francesc Jiménez-Altayó, Ute A. Hellmich, Hitoshi Inada, Antonio Alcaraz, Yuji Furutani, Alfons Nonell-Canals, Jose Luis Vázquez-Ibar, Carmen Domene, Rachelle Gaudet, Alex Perálvarez-Marín
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 473-482 (2024)
TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and metabolism, and is associated with pathologies like muscular dystrophy and cancer. However, TRPV2 p
Externí odkaz:
https://doaj.org/article/fec8ab2a92ba4a038f5fbb653e8b027b
Autor:
Benedikt Goretzki, Christoph Wiedemann, Brett A. McCray, Stefan L. Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K. Donohue, Cy M. Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J. Sumner, Gerhard Hummer, Ute A. Hellmich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large
Externí odkaz:
https://doaj.org/article/164d0c141a984b619e153ae313a859dd
Autor:
Sebastian Bothe, Petra Hänzelmann, Stephan Böhler, Josef Kehrein, Markus Zehe, Christoph Wiedemann, Ute A. Hellmich, Ruth Brenk, Hermann Schindelin, Christoph Sotriffer
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-15 (2022)
The AAA+ ATPase p97 protein is thought to be a potential anticancer target, but direct targeting on its ATPase function has not proven to be a successful strategy in clinical trials due to lack of selectivity. Here, the authors use biolayer interfero
Externí odkaz:
https://doaj.org/article/52166a37c754406fb4c47ec7d205d22e
Autor:
Liying Zhang, Charlotte Simonsen, Lucie Zimova, Kaituo Wang, Lavanya Moparthi, Rachelle Gaudet, Maria Ekoff, Gunnar Nilsson, Ute A. Hellmich, Viktorie Vlachova, Pontus Gourdon, Peter M. Zygmunt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
TRPV2 is activated by temperature and cannabinoids. Here, the authors have used cryo-EM and electrophysiology to identify a cannabinoid binding site distinct from that of cannabidiol as a possible drug target for treatment of inflammation and immune-
Externí odkaz:
https://doaj.org/article/39ad6ca731ce46dbb34893218be33cf8
Autor:
Arens Taga, Margo A. Peyton, Benedikt Goretzki, Thomas Q. Gallagher, Ann Ritter, Amy Harper, Thomas O. Crawford, Ute A. Hellmich, Charlotte J. Sumner, Brett A. McCray
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 3, Pp 375-391 (2022)
Abstract Objective Distinct dominant mutations in the calcium‐permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically cause nonoverlapping diseases of either the neuromuscular or skeletal systems. However, accumulating evid
Externí odkaz:
https://doaj.org/article/55b4815090ee4ddda93b31e6a1e0a6ea
Autor:
Brett A. McCray, Erika Diehl, Jeremy M. Sullivan, William H. Aisenberg, Nicholas W. Zaccor, Alexander R. Lau, Dominick J. Rich, Benedikt Goretzki, Ute A. Hellmich, Thomas E. Lloyd, Charlotte J. Sumner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
TRPV4 dominant mutations cause neuropathy. Here, the authors show that TRPV4 binds and interacts with RhoA, modulating the actin cytoskeleton. Neuropathy-causing mutations of TRPV4 disrupt this complex, leading to RhoA activation and impairment of ne
Externí odkaz:
https://doaj.org/article/c12c32fb25af4c0fbec8907050b017a1
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Spider silk is of interest in material science research. Here the authors show that the tight binding of a spider silk protein domain relies on the amino acid methionine, which is abundant in the domain core where it facilitates dynamic shape adaptio
Externí odkaz:
https://doaj.org/article/cbb044ff25df467b8fda4b6d45554c9a
Autor:
Santo Previti, Roberta Ettari, Carla Di Chio, Rahul Ravichandran, Marta Bogacz, Ute A. Hellmich, Tanja Schirmeister, Sandro Cosconati, Maria Zappalà
Publikováno v:
Molecules, Vol 27, Iss 12, p 3765 (2022)
Human African Trypanosomiasis (HAT) is an endemic protozoan disease widespread in the sub-Saharan region that is caused by T. b. gambiense and T. b. rhodesiense. The development of molecules targeting rhodesain, the main cysteine protease of T. b. rh
Externí odkaz:
https://doaj.org/article/5873f4bdecaa4d6e87e4e4cfc50782cc
Publikováno v:
Trends in Biochemical Sciences. 48:71-81
Interactions between microorganisms are often mediated by specialized metabolites. Although the structures and biosynthesis of these compounds may have been elucidated, microbes exist within complex microbiomes and chemical signals can thus also be s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085ddd131f245735a5e095bb7e22b10a
https://doi.org/10.1016/j.tibs.2022.07.006
https://doi.org/10.1016/j.tibs.2022.07.006
Autor:
Christoph Wiedemann, Benedikt Goretzki, Zoe N. Merz, Frederike Tebbe, Pauline Schmitt, Ute A. Hellmich
Publikováno v:
Biomolecular NMR Assignments. 16:289-296
The mammalian Transient Receptor Potential Vanilloid (TRPV) channels are a family of six tetrameric ion channels localized at the plasma membrane. The group I members of the family, TRPV1 through TRPV4, are heat-activated and exhibit remarkable polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883161995a24e3eebc9073bde0f5c4c8
https://doi.org/10.1007/s12104-022-10093-4
https://doi.org/10.1007/s12104-022-10093-4