Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Utano, Tomaru"'
Autor:
Yuka Nishibata, Suishin Arai, Mai Taniguchi, Issei Nakade, Hodaka Ogawa, Shota Kitano, Yumeka Hosoi, Ayano Shindo, Ryo Nishiyama, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Takafumi Shimizu, William Sinko, Tadashi Nagakura, Yoh Terada, Akihiro Ishizu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cathepsin C (CatC) is an enzyme which regulates the maturation of neutrophil serine proteases (NSPs) essential for neutrophil activation. Activated neutrophils are key players in the innate immune system, and are also implicated in the etiol
Externí odkaz:
https://doaj.org/article/6153810d7d844f19b1a34a9b91aced4d
Autor:
Yasushi Ishii, Aya Fukui-Miyazaki, Sari Iwasaki, Takahiro Tsuji, Kiyohiko Hotta, Hajime Sasaki, Shimpei Nakagawa, Takuma Yoshida, Eri Murata, Koji Taniguchi, Nobuo Shinohara, Akihiro Ishizu, Masanori Kasahara, Utano Tomaru
Publikováno v:
Experimental and Molecular Pathology, Vol 140, Iss , Pp 104939- (2024)
Oxidative stress caused by reactive oxygen species (ROS) is involved in the pathogenesis of renal ischemia-reperfusion injury (I/R injury), a major cause of acute kidney injury and delayed graft function (DGF). DGF is an early transplant complication
Externí odkaz:
https://doaj.org/article/93dea25eecb443caa12f099e7bcd8693
Autor:
Takaharu Ikeda, Tamihiro Kawakami, Kae Yokoyama, Yuka Nishibata, Sakiko Masuda, Utano Tomaru, Akihiro Ishizu
Publikováno v:
Journal of Cutaneous Immunology and Allergy, Vol 6, Iss 6, Pp 241-244 (2023)
Abstract We demonstrated that there were abundant neutrophil extracellular traps (NETs) in the skin biopsies from various types of pyoderma gangrenosum (PG), based on the observation of extended and compact areas of immunolabeling of MPO and Cit H3 p
Externí odkaz:
https://doaj.org/article/046e77e9460d4595a9e6ac23f5306180
Autor:
Ayako Chida‐Nagai, Hiroyuki Akagawa, Saori Sawai, Yue‐Jiao Ma, Satoshi Yakuwa, Jun Muneuchi, Kazushi Yasuda, Hirokuni Yamazawa, Toshiyuki Yamamoto, Emi Takakuwa, Utano Tomaru, Yoshiyuki Furutani, Tatsuya Kato, Gen Harada, Kei Inai, Toshio Nakanishi, Atsushi Manabe, Atsuhito Takeda, Zhi‐Cheng Jing
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Peripheral pulmonary stenosis (PPS) is a condition characterized by the narrowing of the pulmonary arteries, which impairs blood flow to the lung. The mechanisms underlying PPS pathogenesis remain unclear. Thus, the aim of this study was t
Externí odkaz:
https://doaj.org/article/a2cb78169263400cbe224421f099250e
Autor:
Issei Nakade, Yuto Tamura, Fuyu Hashimoto, Yuko Ariza, Shingo Hotta, Hirofumi Fujigaya, Suishin Arai, Mai Taniguchi, Hodaka Ogawa, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background Bruton’s tyrosine kinase (Btk) is an enzyme expressed in leukocytes other than T lymphocytes and plasma cells and involved in B-cell receptor- and Fcγ receptor (FcγR)-mediated signal transduction. Btk inhibitors potentially su
Externí odkaz:
https://doaj.org/article/060a526975d94c7b99f7ab3eb6855475
Autor:
Ryota Azuma, Kazuyoshi Sato, Hiroki Sunadoi, Yasushi Ishii, Utano Tomaru, Masatoshi Motohashi
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 18, Iss 1, Pp 1-6 (2023)
Abstract Background Primary cardiac myxofibrosarcoma is rare and commonly occurs in the left atrium. Myxofibrosarcoma is aggressive and has a high mortality rate due to its high rate of recurrence. Complete surgical resection is considered important;
Externí odkaz:
https://doaj.org/article/f90727e6650d4aae84165c1eea062115
Autor:
Daigo Nakazawa, Yohei Takeda, Masatoshi Kanda, Utano Tomaru, Haruko Ogawa, Takashi Kudo, Satoka Shiratori-Aso, Kanako Watanabe-Kusunoki, Yusho Ueda, Atsuko Miyoshi, Fumihiko Hattanda, Saori Nishio, Ryo Uozumi, Akihiro Ishizu, Tatsuya Atsumi
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Acute kidney injury (AKI) is a common and severe complication of the coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly affects the glomerular and tubular epithelial cells to induce AKI
Externí odkaz:
https://doaj.org/article/0da0d3f5e2554fd6b2872a774f9c79f3
Autor:
Daigo Nakazawa, Yohei Takeda, Masatoshi Kanda, Utano Tomaru, Haruko Ogawa, Takashi Kudo, Satoka Shiratori‐Aso, Kanako Watanabe‐Kusunoki, Yusho Ueda, Atsuko Miyoshi, Fumihiko Hattanda, Saori Nishio, Ryo Uozumi, Akihiro Ishizu, Tatsuya Atsumi
Publikováno v:
FEBS Open Bio, Vol 13, Iss 1, Pp 60-71 (2023)
Severe coronavirus disease 2019 (COVID‐19) is characterized by acute respiratory distress syndrome and multiple organ dysfunction, in which the host immune response plays a pivotal role. Excessive neutrophil activation and subsequent superfluity of
Externí odkaz:
https://doaj.org/article/96abd4d6ac8e4c968aabafa555541ac1
Autor:
Miku Yoshinari, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Yoshihiro Arimura, Koichi Amano, Yukio Yuzawa, Ken-Ei Sada, Tatsuya Atsumi, Hiroaki Dobashi, Hitoshi Hasegawa, Masayoshi Harigai, Seiichi Matsuo, Hirofumi Makino, Akihiro Ishizu
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-9 (2022)
Abstract Background Neutrophil extracellular traps (NETs) are critically involved in microscopic polyangiitis (MPA) pathogenesis, and some patients with MPA possess anti-NET antibody (ANETA). Anti-myosin light chain 6 (MYL6) antibody is an ANETA that
Externí odkaz:
https://doaj.org/article/d4340aa3fa924e148ce2b22195564db0
Autor:
Utano Tomaru, Akihiro Ishizu, Tomohiro Shimizu, Norimasa Iwasaki, Hodaka Ogawa, Shunichi Yokota, Yumeka Hosoi, Ayano Shindo, Naho Ogawa, Ryodai Yamamura, Issei Nakade, Suishin Arai, Mai Taniguchi, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss 2 (2023)
Objectives Methylprednisolone (mPSL) pulse therapy is an essential option for patients with active systemic lupus erythematosus, but there is a risk of adverse events related to microcirculation disorders, including idiopathic osteonecrosis of the fe
Externí odkaz:
https://doaj.org/article/2333c6ddd6e6495f84b15dbdcb64e1b7