Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Uta Eichhorn"'
Autor:
Esther Nesseler, Bernd Kaina, Mathias Schreckenberger, Frank Rösch, Uta Eichhorn, Ralf Schirrmacher, Wilhelm Hamkens
Publikováno v:
Applied Radiation and Isotopes. 56:511-517
The resistance of tumor cells to the cytostatic activity of methylating and chloroethylating anticancer drugs is determined by the level of expression of the DNA repair protein O 6 -methylguanine-DNA-methyl-transferase (MGMT). The synthesis of labell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a13cad985ceb137622b0763c9c2376
https://doi.org/10.1016/s0969-8043(01)00155-5
https://doi.org/10.1016/s0969-8043(01)00155-5
Autor:
Hans-Christian Kliem, Claus-Wilhelm von der Lieth, Jost Reinhard, William E. Hull, Bernd Kaina, Uta Eichhorn, Manfred Wiessler
Publikováno v:
Journal of Medicinal Chemistry. 44:4050-4061
A series of potential inhibitors of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) were synthesized, characterized in detail by NMR, and tested for their ability to deplete MGMT activity in vitro. The new compounds, omeg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d885bf46fc8faa903150b4d2745f88
https://doi.org/10.1021/jm010006e
https://doi.org/10.1021/jm010006e
Publikováno v:
Mutagenesis. 16:233-241
c-Fos and p53 are DNA damage-inducible proteins that are involved in gene regulation, cell cycle checkpoint control and cell proliferation following exposure to genotoxic agents. To investigate comparatively the role of c-Fos and p53 in the maintenan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f5191affe6503ce0677c4ff054015c
https://doi.org/10.1093/mutage/16.3.233
https://doi.org/10.1093/mutage/16.3.233
Autor:
Detmar Beyersmann, Andrea Hartwig, Bernd Kaina, Regina Schlepegrell, Frank Iwitzki, Uta Eichhorn
Publikováno v:
Archives of Toxicology. 72:681-689
Nickel compounds are widespread carcinogens, and although only weakly mutagenic, interfere with nucleotide excision repair and with the repair of oxidative DNA base modifications. In the present study we investigated the effect of nickel(II) on the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de43a6e3d219493089b08d04d7e9cd3b
https://doi.org/10.1007/s002040050561
https://doi.org/10.1007/s002040050561
Publikováno v:
International Journal of Cancer. 77:919-922
The DNA repair protein O6-methylguanine-DNA methyl-transferase (MGMT) is a main determinant of resistance of cells to the cytostatic effects of O6-alkylguanine-generating alkylating agents. The purpose of our study was to assay MGMT activity in cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0f6cf37dd290bfa0956f357f29f5eb
https://doi.org/10.1002/(sici)1097-0215(19980911)77:6<919::aid-ijc20>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19980911)77:6<919::aid-ijc20>3.0.co
Publikováno v:
Oncogene. 17:845-851
The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is inducible by genotoxic stress. MGMT induction results from transcriptional activation of the MGMT gene which is a specific response to DNA damage. A possible factor involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e28f28c98f347142abf22cb52254ce9
https://doi.org/10.1038/sj.onc.1202000
https://doi.org/10.1038/sj.onc.1202000
Autor:
Stefanie Nitzsche, Franz Oesch, Kirsten Schlink, Uta Eichhorn-Grombacher, Bernd Kaina, Kai Janssen
Publikováno v:
Archives of toxicology. 75(5)
The DNA repair enzymes O6-methylguanine-DNA methyltransferase (MGMT) and apurinic/apyrimidinic endonuclease (APE, also known as Ref-1) play an important role in cellular defense against the mutagenic and carcinogenic effects of DNA-damaging agents. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e83c18ea913057d83d1c60153315e2
https://pubmed.ncbi.nlm.nih.gov/11548124
https://pubmed.ncbi.nlm.nih.gov/11548124
Publikováno v:
International journal of cancer. 93(3)
The DNA-repair protein O6-methylguanine-DNA methyltransferase (MGMT) is a decisive determinant of resistance of tumor cells to methylating and chloroethylating anti-cancer drugs. Therefore, selective inhibition of MGMT in tumors is expected to cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af06e8f77a1d24cb19ca26052ae9a621
https://pubmed.ncbi.nlm.nih.gov/11433402
https://pubmed.ncbi.nlm.nih.gov/11433402
Autor:
A Ritter, J Lips, M Z Zdzienicka, Manfred Wiessler, Bernd Kaina, R Becker, B Bertram, Uta Eichhorn
Publikováno v:
British Journal of Cancer
To study molecular aspects of cytotoxicity of the anticancer drug β-D-glucose-ifosfamide mustard we investigated the potential of the agent to induce apoptosis and DNA breakage. Since β-D-glucose-ifosfamide mustard generates DNA interstrand crossli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460868ca606e2bdc6f70789c32f57709
https://pubmed.ncbi.nlm.nih.gov/11857024
https://pubmed.ncbi.nlm.nih.gov/11857024
Publikováno v:
Carcinogenesis. 21(10)
Hyperbaric oxygen (HBO) treatment of human subjects (i.e. exposure to 100% oxygen at a pressure of 2.5 ATA for a total period of 3 x 20 min) caused clear and reproducible DNA damage in lymphocytes, as detected with the comet assay (single cell gel el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e57ecfc803034697f1f6639b07ee36
https://pubmed.ncbi.nlm.nih.gov/11023535
https://pubmed.ncbi.nlm.nih.gov/11023535