Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Uta Dahmen"'
Autor:
Mohamed Albadry, Jonas Küttner, Jan Grzegorzewski, Olaf Dirsch, Eva Kindler, Robert Klopfleisch, Vaclav Liska, Vladimira Moulisova, Sandra Nickel, Richard Palek, Jachym Rosendorf, Sylvia Saalfeld, Utz Settmacher, Hans-Michael Tautenhahn, Matthias König, Uta Dahmen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
There is a lack of systematic research exploring cross-species variation in liver lobular geometry and zonation patterns of critical drug-metabolizing enzymes, a knowledge gap essential for translational studies. This study investigated the critical
Externí odkaz:
https://doaj.org/article/46affa48e26a429382b68c799c8fe292
Autor:
Mohamed Albadry, Sebastian Höpfl, Nadia Ehteshamzad, Matthias König, Michael Böttcher, Jasna Neumann, Amelie Lupp, Olaf Dirsch, Nicole Radde, Bruno Christ, Madlen Christ, Lars Ole Schwen, Hendrik Laue, Robert Klopfleisch, Uta Dahmen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Little is known about the impact of morphological disorders in distinct zones on metabolic zonation. It was described recently that periportal fibrosis did affect the expression of CYP proteins, a set of pericentrally located drug-metabolizi
Externí odkaz:
https://doaj.org/article/ab94040416be4b768ec4f1e797e54e72
Autor:
Janine Arlt, Sebastian Vlaic, Ronny Feuer, Maria Thomas, Utz Settmacher, Uta Dahmen, Olaf Dirsch
Publikováno v:
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-14 (2022)
Abstract Background In previous studies, five vasoactive drugs were investigated for their effect on the recovery process after extended liver resection without observing relevant improvements. We hypothesized that an analysis of gene expression coul
Externí odkaz:
https://doaj.org/article/53211de52b3e4a2ea021119482868a52
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 2, p 449 (2024)
Background: Patients with angina are often suffering from comorbidities such as varying degrees of hepatic dysfunction. However, the impact of angina on the incidence of hepatic failure (HF) remains unclear. Methods: The genetic data were retrieved f
Externí odkaz:
https://doaj.org/article/9f59ff0ee67d4d3fab5cdb5fb7866575
Autor:
Chuanfeng Hua, Weiwei Wei, Tianjiao Zhang, Fengming Xu, Olaf Dirsch, André Homeyer, Utz Settmacher, Uta Dahmen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Portal vein ligation (PVL) has been adopted to induce hypertrophy of the future liver remnant (FLR) in patients with primarily irresectable liver tumor. However, regeneration of the FLR is not always sufficient to allow curative resection of
Externí odkaz:
https://doaj.org/article/6fdff7da51ad485391a7d31594b5606b
Autor:
Maria Stefania Massaro, Petra Kochová, Richard Pálek, Jáchym Rosendorf, Lenka Červenková, Uta Dahmen, Václav Liška, Vladimíra Moulisová
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The use of biologically derived vessels as small-diameter vascular grafts in vascular diseases is currently intensely studied. Vessel decellularization provides a biocompatible scaffold with very low immunogenicity that avoids immunosuppression after
Externí odkaz:
https://doaj.org/article/4969f4f99e4343f2b2c5b5dcd2a2a068
Autor:
Beate Richter, Constanze Sänger, Franziska Mussbach, Hubert Scheuerlein, Utz Settmacher, Uta Dahmen
Publikováno v:
Frontiers in Surgery, Vol 9 (2022)
Background and AimsPatients with malignant biliary obstruction do not seem to benefit from “two-stage hepatectomy” due to an impairment of liver regeneration. We designed a novel model of “repeated regeneration stimuli” in rats mimicking a
Externí odkaz:
https://doaj.org/article/f80cae21471b4995a363696af009c0ed
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/c6bc073c273a4fd681eee0371a666510
Autor:
Daniel Budelmann, Hendrik Laue, Nick Weiss, Uta Dahmen, Lorenza A. D’Alessandro, Ina Biermayer, Ursula Klingmüller, Ahmed Ghallab, Reham Hassan, Brigitte Begher-Tibbe, Jan G. Hengstler, Lars Ole Schwen
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100001- (2022)
Many physiological processes and pathological phenomena in the liver tissue are spatially heterogeneous. At a local scale, biomarkers can be quantified along the axis of the blood flow, from portal fields (PFs) to central veins (CVs), i.e., in zonate
Externí odkaz:
https://doaj.org/article/f0dec92db057496e8dbc2372a3ce73d9
Autor:
Beate Richter, Constanze Sänger, Franziska Mussbach, Hubert Scheuerlein, Utz Settmacher, Uta Dahmen
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271975 (2022)
BackgroundThe selection of the appropriate species is one of the key issues in experimental medicine. Bile duct ligation is the mostly used experimental model in rodents to explore special aspects of occlusive cholestasis. We aimed to clarify if rats
Externí odkaz:
https://doaj.org/article/ecdfd53b2cce4a969f2fc502941104cb