Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Uta, Schurigt"'
Autor:
Benjamin Frank, Ana Marcu, Antonio Luis de Oliveira Almeida Petersen, Heike Weber, Christian Stigloher, Jeremy C. Mottram, Claus Juergen Scholz, Uta Schurigt
Publikováno v:
Parasites & Vectors, Vol 8, Iss 1, Pp 1-31 (2015)
Abstract Background Autophagy participates in innate immunity by eliminating intracellular pathogens. Consequently, numerous microorganisms have developed strategies to impair the autophagic machinery in phagocytes. In the current study, interactions
Externí odkaz:
https://doaj.org/article/a6a6490b278f427c83cfd4c1e143bda7
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10873-10883 (2015)
Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula
Externí odkaz:
https://doaj.org/article/a0f2793ce8974edfa56c8dec8f96c456
Autor:
Anita Masic, Ana Maria Valencia Hernandez, Sudipta Hazra, Jan Glaser, Ulrike Holzgrabe, Banasri Hazra, Uta Schurigt
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142386 (2015)
Human leishmaniasis covers a broad spectrum of clinical manifestations ranging from self-healing cutaneous leishmaniasis to severe and lethal visceral leishmaniasis caused among other species by Leishmania major or Leishmania donovani, respectively.
Externí odkaz:
https://doaj.org/article/8e85e456b48646d296cee5ea926ae1ce
Autor:
Tanja Schirmeister, Uta Schurigt, Caroline Schad, Heidrun Moll, Ulrike Baum, Benjamin Frank, Felix Mattern, Uwe Dietzel, Carlos Gomes, Alicia Ponte-Sucre
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:797-805
Leishmaniasis is one of the major neglected tropical diseases of the world. Druggable targets are the parasite cysteine proteases (CPs) of clan CA, family C1 (CAC1). In previous studies, we identified two peptidomimetic compounds, the aziridine-2,3-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9170931911ee25c0855c956cb513d439
https://doi.org/10.1128/aac.00426-15
https://doi.org/10.1128/aac.00426-15
Publikováno v:
Organic & Biomolecular Chemistry
A flexible synthetic route to (R)-harmonine ((R)-1), the toxic principle of the Asian lady beetle Harmonia axyridis (H. axyridis), via reductive olefination of the macrocyclic lactone (S)-5, is reported. High enantiomeric purity is achieved by enanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3336052af26e4f66ed047508bab06591
https://doi.org/10.1039/c5ob00461f
https://doi.org/10.1039/c5ob00461f
Autor:
Gerhard Bringmann, Christoph Schneider, Martina Schultheis, Heidrun Moll, Sebastian K. Bischof, Tobias Schwarz, Katja Thomale, Uta Schurigt
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3003-3011
In most laboratories, the screening for leishmanicidal compounds is carried out with Leishmania promastigotes or axenic amastigotes. However, the best approach to identify leishmanicidal compounds is the use of amastigotes residing in macrophages. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcd154abcdc6c9bf6bc73d11b048d26
https://doi.org/10.1128/aac.02201-12
https://doi.org/10.1128/aac.02201-12
Publikováno v:
Trypanosomatid Diseases: Molecular Routes to Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebca41497de2ab46a0fd1582a56b0556
https://doi.org/10.1002/9783527670383.ch6
https://doi.org/10.1002/9783527670383.ch6
Autor:
Sebastian Müller, Uta Schurigt, Thomas Reinheckel, Mieczyslaw Gajda, Marie Follo, C Sieber, Lisa Sevenich, Fee Werner, Christoph Peters
Publikováno v:
Oncogene; Vol 30
Oncogene
Oncogene
Elevated expression of the cysteine protease cathepsin B (CTSB) has been correlated with a poor prognosis for cancer patients. In order to model high CTSB expression in mammary cancer, transgenic mice expressing human CTSB were crossed with transgeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657f0dcc9f7f999dd636cd3781140397
Autor:
Ulrike Baum, Katja Thomale, Martina Schultheis, Heidrun Moll, Caroline Schad, Christin Glowa, Johannes K. Schnitzer, Norbert Schaschke, Tanja Schirmeister, Uta Schurigt
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:5028-5041
The papain-like cysteine cathepsins expressed by Leishmania play a key role in the life cycle of these parasites, turning them into attractive targets for the development of new drugs. We previously demonstrated that two compounds of a series of pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62363141172078b32f929db42d63937
https://doi.org/10.1128/aac.00327-10
https://doi.org/10.1128/aac.00327-10
Autor:
Banasri Hazra, Andreas Hartung, Heidrun Moll, Sukalyani Debnath, Subhalakshmi Ghosh, Petra Kapková, Martina Schultheis, Ulrike Holzgrabe, Uta Schurigt, Katja Thomale, Sudipta Hazra
Publikováno v:
Parasitology Research. 108:861-871
Leishmanial diseases, posing a public health problem worldwide, are caused by Leishmania parasites with a dimorphic life cycle alternating between the promastigote and amastigote forms. Promastigotes transmitted by the vector are transformed into ama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f4fd50b01c9021d3e3eda40fdaa93f
https://doi.org/10.1007/s00436-010-2127-0
https://doi.org/10.1007/s00436-010-2127-0